التفاصيل البيبلوغرافية
| العنوان: |
Increased serum 12-hydroxyeicosatetraenoic acid levels are correlated with an increased risk of diabetic retinopathy in both children and adults with diabetes. |
| المؤلفون: |
Chen, Shuli, Qian, Yu, Lin, Qiurong, Chen, Zhangling, Xiang, Zhaoyu, Cui, Lipu, Sun, Jiaqi, Qin, Xinran, Xu, Yi, Lu, Lina, Zou, Haidong |
| المصدر: |
Acta Diabetologica; Nov2022, Vol. 59 Issue 11, p1505-1513, 9p |
| مصطلحات موضوعية: |
DIABETES in children, DIABETIC retinopathy, TYPE 1 diabetes, TYPE 2 diabetes, PEOPLE with diabetes |
| مصطلحات جغرافية: |
SHANGHAI (China) |
| مستخلص: |
Purpose: To investigate the relationship between serum 12-Hydroxyeicosatetraenoic acid (12-HETE) and diabetic retinopathy (DR) in children with type 1 diabetes mellitus (T1DM) and adults with type 2 diabetes mellitus (T2DM). Methods: Children from the Shanghai Children and Adolescent Diabetes Eye (SCADE) study and adults from the Shanghai Cohort Study of Diabetic Eye Disease (SCODE) were examined in 2021. Serum 12-HETE levels were detected and compared. Multivariate logistic regression was used to analyze the relationship between 12-HETE and the rate of DR in diabetic patients. Results: The child study included 4 patients with new-onset DR and 24 patients with T1DM without DR. In children with T1DM, the 12-HETE level was significantly higher in those with DR (P = 0.003). The adult study had two sets, for testing and verification. The test set included 28 patients with new-onset DR and 24 T2DM patients with a course of ≥ 20 years who had never developed DR. The verification set included 41 patients with DR, 50 patients without DR and 50 healthy controls. In the adult test set, the 12-HETE level was significantly higher in patients with DR than in those with T2DM without DR (P = 0.003). In the verification set, the 12-HETE level of patients with DR was significantly higher than that of patients without DR (P < 0.0001) and the healthy controls (P < 0.0001). Multivariate logistic regression indicated that 12-HETE was independently associated with DR in both children (odds ratio [OR] 1.06, 95% confidence interval [CI] 1.00–1.13, P = 0.041) and adults (test set [OR 9.26, 95% CI 1.77–48.59, P = 0.008], verification set [OR 10.49, 95% CI 3.23–34.05, P < 0.001]). Conclusion: Higher serum 12-HETE levels are positively correlated with an increased risk of DR in children with T1DM and adults with T2DM. [ABSTRACT FROM AUTHOR] |
|
Copyright of Acta Diabetologica is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
