نتائج البحث

1

Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding

المؤلفون: Yvon C. Chagnon, G. Sun, Claude Bouchard, André J. Tremblay, Olavi Ukkola

المصدر: European Journal of Clinical Nutrition. 55:1008-1015

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Thyroid Hormones, Genetic Linkage, Medicine (miscellaneous), Clinical nutrition, Biology, Polymerase Chain Reaction, Ion Channels, Mitochondrial Proteins, Thyroid-stimulating hormone, Internal medicine, medicine, Uncoupling protein, Humans, Uncoupling Protein 3, Uncoupling Protein 2, Obesity, Uncoupling Protein 1, UCP3, Nutrition and Dietetics, Uncoupling Agents, Genetic Variation, Membrane Proteins, Membrane Transport Proteins, Proteins, Twins, Monozygotic, Thermogenin, Respiratory quotient, Endocrinology, Basal metabolic rate, Body Composition, Basal Metabolism, medicine.symptom, Carrier Proteins, Energy Intake, Energy Metabolism, Weight gain, Polymorphism, Restriction Fragment Length

الوصف: Objective: To evaluate the effects of uncoupling protein (UCP) 1, UCP2 and UCP3 gene variants on body composition and metabolic changes in response to chronic overfeeding and the recovery after the period of overfeeding. Subjects and design: Twenty-four normal weight men (21±2 y), who constituted 12 pairs of identical twins, ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. The subjects were asked to return to the laboratory for testing at 4 months and for a final examination 5 y after completion of the overfeeding protocol. Methods: Resting metabolic rate (RMR) measurements were performed before and after overfeeding. A 4.2 MJ test meal was consumed, after which calorimetric measurements were continued for 240 min. Total body fat was assessed by hydrodensitometry and total subcutaneous fat by the sum of eight skinfolds. Polymorphisms were typed by PCR and PCR-RFLP-techniques. Thyroid stimulating hormone (TSH) concentrations after a thyrotropin releasing hormone (TRH) injection were measured by radioimmunoassay (RIA). Results: The changes in body weight and adiposity were not different between UCP1 Bcl I, UCP2 alanine to valine (A55V), UCP2 insertion/deletion (I/D) or UCP3 Rsa I genotypes. However, the recovery from overfeeding was worse among G-allele carriers of the UCP1 Bcl I, I allele non-carriers of the UCP2 I/D, AV heterozygote subjects of the UCP2 A55V and CC subjects of the UCP3 Rsa I polymorphisms. RMR was lower both before (P=0.01) and after (P=0.001) overfeeding in subjects with the CC genotype of the UCP3 Rsa I polymorphism. Moreover, after overfeeding, the UCP2 A55V heterozygote and UCP3 Rsa I CC homozygote subjects had significantly higher respiratory quotient (RQ) values at rest (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3beb5f5760f9c01e99d59471069ecf1Test
https://doi.org/10.1038/sj/ejcn/1601261Test

2

Superior Mesenteric Artery Syndrome Accompanied by Acute-onset Type 1 Diabetes Complicated with Graves' Disease

المؤلفون: Eijiro Yamada, Yasuyo Nakajima, Emi Ishida, Satoshi Yoshino, Shuichi Okada, Kazuhiko Horiguchi, Shunichi Matsumoto, Mai Sue-Nagumo, Masanobu Yamada

المصدر: Internal Medicine. 61:1555-1560

الوصف: A 35-year-old man experienced general fatigue and could not eat solid food because of nausea and vomiting. His weight abruptly decreased from 49 to 45 kg after 2 weeks. A detailed examination indicated superior mesenteric artery syndrome (SMAS) accompanied by acute-onset type 1 diabetes complicated by Graves' disease, referred to as autoimmune polyglandular syndrome type 3A (APS3A). Although SMAS has a good prognosis, some cases require emergency surgery, especially when complicated by gastric perforation. In our case, APS3A and SMAS developed rapidly and at approximately the same time, resulting in a cycle of mutual exacerbation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f59ada3f465d5c49610b5ffca899b8Test
https://doi.org/10.2169/internalmedicine.8364-21Test

3

Novel glycoproteins identify preclinical atherosclerosis among women with previous preeclampsia regardless of type 1 diabetes status

المؤلفون: Marga Giménez, Eva López, Irene Vinagre, Eva Meler, Antonio J. Amor, Ignacio Conget, Verónica Perea, Maite Valverde, Laura Codina, Maria J. Barahona, Núria Alonso, Xavier Urquizu

المصدر: Nutrition, Metabolism and Cardiovascular Diseases. 31:3407-3414

الوصف: Background and aims Information regarding inflammation and cardiovascular disease (CVD) risk in type 1 diabetes (T1D) or preeclampsia (PE) is scarce. We assessed differences in inflammation markers according to the presence of both conditions and their association with atherosclerosis. Methods and results We recruited 112 women without CVD and last pregnancy ≥5 years previously (n = 28 per group): a)T1D and PE; b)T1D without PE; c)PE without T1D; and d)Controls (without T1D or PE). Groups were matched by several CVD risk factors, and diabetes duration and retinopathy in T1D. Carotid intima-media thickness (IMT) and plaque presence (IMT ≥1.5 mm) were assessed by ultrasonography. Inflammatory markers included classical variables (leucocytes and high-sensitivity C-reactive protein [hsCRP]) and glycoproteins by nuclear magnetic resonance (1H-NMR) spectroscopy (GlycA, GlycB, GlycF and the height/width [H/W] ratios of GlycA and GlycB). The age of the participants was 44.9 ± 7.8 years, and 20.5% harbored plaque. There were no differences in inflammatory markers among the four study groups. Overall, in multivariate-adjusted models, all 1H-NMR-glycoproteins (except GlycB) were positively associated with IMT measures (IMT of bulb and maximum-IMT of any carotid segment; p Conclusions High 1H-NMR-glycoprotein concentrations have a negative impact on carotid atherosclerosis among women with preeclampsia, regardless of T1D status.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcedeb23bc8d78ef283a973fbc8f4f2fTest
https://doi.org/10.1016/j.numecd.2021.08.041Test

4

Liraglutide changes body composition and lowers added sugar intake in overweight persons with insulin pump‐treated type 1 diabetes

المؤلفون: Dorte Vistisen, Henrik U. Andersen, Kirsten Nørgaard, Jens-Erik Beck Jensen, Sten Madsbad, Sjudur Frodi Olsen, Thorhallur I. Halldorsson, Christian Seerup Frandsen, Thomas F. Dejgaard, Signe Schmidt

المصدر: Schmidt, S, Frandsen, C S, Dejgaard, T F, Vistisen, D, Halldorsson, T, Olsen, S F, Jensen, J-E B, Madsbad, S, Andersen, H U & Nørgaard, K 2022, ' Liraglutide changes body composition and lowers added sugar intake in overweight persons with insulin pump-treated type 1 diabetes ', Diabetes, Obesity and Metabolism, vol. 24, no. 2, pp. 212-220 . https://doi.org/10.1111/dom.14567Test

الوصف: AimsTo present secondary outcome analyses of liraglutide treatment in overweight adults with insulin pump-treated type 1 diabetes (T1D), focusing on changes in body composition and dimensions, and to evaluate changes in food intake to identify potential dietary drivers of liraglutide-associated weight loss.Materials and methodsA 26-week randomized placebo-controlled study was conducted to investigate the efficacy and safety of liraglutide 1.8 mg daily in 44 overweight adults with insulin pump-treated T1D and glucose levels above target, and demonstrated significant glycated haemoglobin (HbA1c)- and body weight-reducing effects. For secondary outcome analysis, dual X-ray absorptiometry scans were completed at Weeks 0 and 26, and questionnaire-based food frequency recordings were obtained at Weeks 0, 13 and 26 to characterize liraglutide-induced changes in body composition and food intake.ResultsTotal fat and lean body mass decreased in liraglutide-treated participants (fat mass −4.6 kg [95% confidence interval {CI} −5.7; −3.5], P ConclusionsLiraglutide lowered fat and lean body mass compared with placebo. Further, liraglutide reduced intake of added sugars. However, no significant difference in total daily energy intake was detected between liraglutide- and placebo-treated participants.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b120a58b8882580fa6a8d8d706b0a72fTest
https://doi.org/10.1111/dom.14567Test

5

H3K23/H3K36 hypoacetylation and HDAC1 up-regulation are associated with adverse consequences in obstructive sleep apnea patients

المؤلفون: Chang-Chun Hsiao, Ting-Ya Wang, Mao-Chang Su, C Lee, Yong-Yong Lin, Meng-Chih Lin, Po-Yuan Hsu, Hsin-Ching Lin, Yung-Che Chen, Chia-Wei Liou, Chien-Hung Chin

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

مصطلحات موضوعية: Male, Jumonji Domain-Containing Histone Demethylases, THP-1 Cells, medicine.medical_treatment, Excessive daytime sleepiness, Histone Deacetylase 1, Diseases, medicine.disease_cause, Cohort Studies, Histones, Medicine, Continuous positive airway pressure, Hypoxia, Promoter Regions, Genetic, Sleep Apnea, Obstructive, Multidisciplinary, biology, Continuous Positive Airway Pressure, Molecular medicine, Intermittent hypoxia, Acetylation, Middle Aged, Up-Regulation, Histone, C-Reactive Protein, NADPH Oxidase 1, Female, medicine.symptom, Adult, medicine.medical_specialty, Polysomnography, Science, Disorders of Excessive Somnolence, Peripheral blood mononuclear cell, Article, Sleep Apnea Syndromes, Medical research, Internal medicine, Humans, business.industry, Snoring, DNA Methylation, medicine.disease, HDAC1, Obstructive sleep apnea, Endocrinology, Case-Control Studies, biology.protein, Leukocytes, Mononuclear, business, Oxidative stress, Biomarkers

الوصف: The aim of this study is to determine the roles of global histone acetylation (Ac)/methylation (me), their modifying enzymes, and gene-specific histone enrichment in obstructive sleep apnea (OSA). Global histone modifications, and their modifying enzyme expressions were assessed in peripheral blood mononuclear cells from 56 patients with OSA and 16 matched subjects with primary snoring (PS). HIF-1α gene promoter-specific H3K36Ac enrichment was assessed in another cohort (28 OSA, 8 PS). Both global histone H3K23Ac and H3K36Ac expressions were decreased in OSA patients versus PS subjects. H3K23Ac expressions were further decreased in OSA patients with prevalent hypertension. HDAC1 expressions were higher in OSA patients, especially in those with excessive daytime sleepiness, and reduced after more than 6 months of continuous positive airway pressure treatment. H3K79me3 expression was increased in those with high C-reactive protein levels. Decreased KDM6B protein expressions were noted in those with a high hypoxic load, and associated with a higher risk for incident cardiovascular events or hypertension. HIF-1α gene promoter-specific H3K36Ac enrichment was decreased in OSA patients versus PS subjects. In vitro intermittent hypoxia with re-oxygenation stimuli resulted in HDAC1 over-expression and HIF-1α gene promoter-specific H3K36Ac under-expression, while HDAC1 inhibitor, SAHA, reversed oxidative stress through inhibiting NOX1. In conclusions, H3K23/H3K36 hypoacetylation is associated with the development of hypertension and disease severity in sleep-disordered breathing patients, probably through up-regulation of HDAC1, while H3K79 hypermethylation is associated with higher risk of cardiovascular diseases, probably through down-regulation of KDM6B.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5df41e5c83da43011517e8da1818415Test
https://doaj.org/article/7aa0ddc6b9dc4f28aa0dbb61d068aad7Test

6

Flash glucose monitoring system: impact on glycemic control and body mass index in type 1 diabetes mellitus

المؤلفون: Juliana Marques Sá, Sara Lopes, Inês Ferreira Barros, Maria Joana Santos, Mariana Barbosa

المصدر: Archives of Endocrinology and Metabolism, Vol 65, Iss 5, Pp 640-647 (2021)
Archives of Endocrinology and Metabolism, Issue: ahead, Published: 25 OCT 2021
Archives of Endocrinology and Metabolism v.65 n.5 2021
Arquivos de Endocrinologia e Metabolismo
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
Archives of Endocrinology and Metabolism, Volume: 65, Issue: 5, Pages: 640-647, Published: 29 SEP 2021

الوصف: Objective: Flash glucose monitoring (FGM) is increasingly used in type 1 diabetes mellitus (T1D) management. This study aimed to assess glycated hemoglobin (HbA1c) and body mass index (BMI) in the first year of FGM use in patients with T1D and to identify predictive factors of benefit associated with its use. Subjects and methods: Retrospective study of T1D patients, using FGM for ≥ 6 months and under intensive insulin therapy with multiple daily injections. Results: In 179 patients with a median (Md) age of 43.0 years (P25 31.0; P75 52.0) and disease duration of 18.0 years (P25 10.0; P75 28.0), initial HbA1c was 7.9% (P25 7.2; P75 8.8) and initial BMI was 24.0 kg/m2 (P25 21.9; P75 26.2). With FGM, HbA1c improved significantly to 7.6% (P25 7.0; P75 8.3) at 6 months and 7.7% (P25 6.95; P75 8.5) at 12 months (p < 0.05), with more patients with HbA1c < 7% (16.1% vs 22.5%) and fewer patients with HbA1c ≥ 8% (49.1% vs 35.8%) (p < 0.05). Initial HbA1c 8.0-8.9% (HR 1.886; 95% CI 1.321-2.450) and ≥ 9.0% (HR 3.108, 95% CI 2.454-3.761) predicted greater HbA1c reduction. BMI increased significantly, especially between 6 and 12 months (BMI Md 23.8 [P25 21.9; P75 26.2] kg/m2 and 24.0 [P25 22.0; P75 26.2] kg/m2, respectively) (p < 0.05). Overweight (HR 4.319, 95% CI 3.185-5.453) and obesity (HR 8.112, 95% CI 3.919-12.306) predicted greater weight gain. Conclusions: FGM use was associated with significant improvement in HbA1c, mainly in patients with worse previous glycemic control. It was also associated with increased BMI, especially if baseline BMI ≥ 25 kg/m2, so weight control strategies should be emphasized.

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d19a010121c80a7df4798492672feeTest
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972021000500640&tlng=enTest

7

Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor

المؤلفون: Kyoichi Kaira, Ou Yamaguchi, Hiroyuki Nitanda, Hirozo Sakaguchi, Akitoshi Yanagihara, Hiroshi Kagamu, Tomonori Kawasaki, Tetsuya Umesaki, Kunihiko Kobayashi, Atsuto Mouri, Hisao Imai, Kosuke Hashimoto, Ryo Taguchi, Ichiei Kuji, Masanori Yasuda

المصدر: Cancer Medicine, Vol 10, Iss 18, Pp 6317-6326 (2021)
Cancer Medicine

مصطلحات موضوعية: Male, Cancer Research, Pathology, Biopsy, B7-H1 Antigen, Warburg Effect, Oncologic, Neoplasms, Glandular and Epithelial, Thymic carcinoma, Research Articles, RC254-282, Aged, 80 and over, Glucose Transporter Type 1, medicine.diagnostic_test, biology, HIF‐1α, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Thymectomy, Oncology, Positron emission tomography, thymic epithelial tumor, immunohistochemistry, Immunohistochemistry, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Thymoma, Thymus Gland, Fluorodeoxyglucose F18, PD-L1, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Performance status, business.industry, Clinical Cancer Research, Thymus Neoplasms, Hypoxia (medical), medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Programmed Cell Death 1 Ligand 2 Protein, PD‐L1, Positron-Emission Tomography, PD‐L2, biology.protein, Tumor Hypoxia, GLUT1, 18F‐FDG uptake, business

الوصف: Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint. Conclusion 18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells.
High expression of PD‐L1/PD‐L2 was closely associated with high accumulation of 18F‐FDG. Angiogenetic markers were linked to the expression of PD‐L1/PD‐L2. PD‐L1 and PD‐L2 exhibited a close relationship with upregulation of tumor glucose metabolism and hypoxia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15261651d62bd866f1c6478c8c6c3373Test
https://doaj.org/article/a8142366e6a1438799401c111ae0c803Test

8

Changes in plasma and urine metabolites associated with empagliflozin in patients with type 1 diabetes

المؤلفون: Kumar Sharma, Mir Tariq Ali, David Z.I. Cherney, Daniel Montemayor, Hongyan Liu, Patrick R. Lawler, Leif E. Lovblom, Hongping Ye, Vikas S. Sridhar, Daniel Scarr, Yuliya Lytvyn, Bruce A. Perkins, Jiwan Kim

المصدر: Diabetes, Obesity and Metabolism. 23:2466-2475

الوصف: AIM To examine the impact of the sodium-glucose co-transporter-2 inhibitor, empagliflozin, on plasma and urine metabolites in participants with type 1 diabetes. MATERIAL AND METHODS Participants (n = 40, 50% male, mean age 24.3 years) with type 1 diabetes and without overt evidence of diabetic kidney disease had baseline assessments performed under clamped euglycaemia and hyperglycaemia, on two consecutive days. Participants then proceeded to an 8-week, open-label treatment period with empagliflozin 25 mg/day, followed by repeat assessments under clamped euglycaemia and hyperglycaemia. Plasma and urine metabolites were first grouped into metabolic pathways using MetaboAnalyst software. Principal component analysis was performed to create a representative value for each sufficiently represented metabolic group (false discovery rate ≤ 0.1) for further analysis. RESULTS Of the plasma metabolite groups, tricarboxylic acid (TCA) cycle (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85379caa8dec557abd4fd02ab5d5993Test
https://doi.org/10.1111/dom.14489Test

9

Systematic Review: Diabetes Family Conflict in Young People With Type 1 Diabetes

المؤلفون: Helen L. Barrett, Vanessa E. Cobham, Genevieve A. Dingle, Anna Hickling

المصدر: Journal of Pediatric Psychology. 46:1091-1109

مصطلحات موضوعية: Adult, Blood Glucose, Gerontology, Adolescent, Family Conflict, Inclusion (disability rights), 030209 endocrinology & metabolism, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Quality of life, Diabetes mellitus, Developmental and Educational Psychology, medicine, Humans, 030212 general & internal medicine, Depression (differential diagnoses), Aged, Blood glucose monitoring, Type 1 diabetes, medicine.diagnostic_test, business.industry, Blood Glucose Self-Monitoring, medicine.disease, Diabetes Mellitus, Type 1, chemistry, Pediatrics, Perinatology and Child Health, Quality of Life, Anxiety, Glycated hemoglobin, medicine.symptom, business

الوصف: Objective To investigate the relationships between diabetes-specific family conflict and health outcomes of young people with type 1 diabetes (T1D). Methods A systematic review was performed according to the PRISMA statement (registration number: CRD42020164988). PubMed, Embase, PsycNET, reference lists of included studies, and other relevant reviews were searched (1990–2020). Two independent reviewers screened titles, abstracts, and full-texts. Studies were included if they sampled young people with T1D (mean age between 14 and 25 years) and examined the relationship between diabetes-specific family conflict and the following outcomes: glycated hemoglobin (HbA1c), treatment adherence, blood glucose monitoring, depression, anxiety, quality of life, and/or well-being. Results A total of 20 studies met the predetermined inclusion criteria. Greater diabetes-specific family conflict was significantly related to higher HbA1c values in 17 studies. Seven studies reported a significant association between greater diabetes family conflict and suboptimal treatment adherence and/or less frequent blood glucose monitoring. However, significant relationships between conflict and HbA1c and/or treatment adherence were not found in four studies. Seven studies in total reported that greater diabetes family conflict was significantly related to poorer quality of life or well-being and greater depressive and/or anxiety symptoms in young people. Conclusions Diabetes-specific family conflict is associated with some adverse health outcomes for young people with T1D. However, more longitudinal studies of young people aged older than 16 years are needed. Screening for and addressing diabetes-specific family conflict is recommended, given the growing number of studies linking family conflict to various adverse health outcomes in young people with T1D.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a36283248d73b0ba69971a8ef74a11Test
https://doi.org/10.1093/jpepsy/jsab052Test

10

Maternal prepregnancy BMI and physical activity and type 1 diabetes in the offspring

المؤلفون: Marianna Cortese, Alberto Ascherio, Kassandra L. Munger, Catarina Machado Azeredo

المصدر: Pediatric Diabetes. 22:992-1002

الوصف: Background Previous studies showed conflicting results on the association between maternal pre-pregnancy body mass index (BMI) and type 1 diabetes in the offspring, and the role of maternal pre-pregnancy physical activity is unclear. We aimed to assess whether maternal pre-pregnancy BMI and physical activity predict type 1 diabetes in their offspring. Methods Prospective study including women participating in the Nurses' Health Study II with follow-up from 1989 to 2011. Women repeatedly reported their BMI and physical activity, from which pre-pregnancy exposures were derived; and retrospectively reported their BMI at age 18 and physical activity at ages 18-22, considered early adulthood exposure. We estimated risk ratios (RR) and 95% confidence intervals (95%CI) using generalized estimating equations, adjusted for covariates. Findings at p Results We identified 276 cases of type 1 diabetes among offspring (n=70,168) with maternal pre-pregnancy information and 448 cases among offspring (n=111,692) with maternal early adulthood information. Pre-pregnancy and early adulthood maternal BMI and physical activity were not associated with offspring type 1 diabetes. The RR comparing overweight to normal weight mothers was 1.08 (95%CI: 0.73-1.59) and comparing obese to normal weight was 0.94 (95%CI: 0.49-1.79, p-trend: 0.98). Comparing highest to lowest quartile of maternal physical activity the RR was 0.90 (95%CI: 0.61-1.32; p-trend: 0.73). Maternal type 2 diabetes was associated with an increased risk of type 1 diabetes in the offspring (RR=1.87; 95%CI: 1.25-2.80). Conclusions Our findings do not support a relationship between maternal pre-pregnancy BMI or physical activity and the risk of type 1 diabetes in the offspring. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66bb1036019e64525f828a5ba480ca06Test
https://doi.org/10.1111/pedi.13248Test

تنقيح النتائج