نتائج البحث

1

Overexpression of hypoxia-inducible factor 1α is associated with neutrophilic inflammation in chronic rhinosinusitis with nasal polyps

المؤلفون: Xianting Hu, Hangyu Xu, Yu Wang, Jia Zhang, Weiping Wen, Hua-Bin Li, Hairong Shu, Zhijian Yu, Miaomiao Han

المصدر: Auris Nasus Larynx. 47:401-409

مصطلحات موضوعية: Adult, Male, Neutrophils, medicine.medical_treatment, Blotting, Western, Drug Resistance, Dexamethasone, 03 medical and health sciences, Nasal Polyps, 0302 clinical medicine, Western blot, Clarithromycin, medicine, Humans, Nasal polyps, RNA, Messenger, Sinusitis, 030223 otorhinolaryngology, Glucocorticoids, Rhinitis, Inflammation, medicine.diagnostic_test, Reverse Transcriptase Polymerase Chain Reaction, business.industry, General Medicine, Middle Aged, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Anti-Bacterial Agents, Cytokine, Otorhinolaryngology, Case-Control Studies, 030220 oncology & carcinogenesis, Chronic Disease, Immunology, Cytokines, Immunohistochemistry, Drug Therapy, Combination, Female, Surgery, medicine.symptom, business, Glucocorticoid, medicine.drug

الوصف: This study aimed to assess the possible role of hypoxia-inducible factor 1α (HIF-1α) in promoting neutrophilic inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP) patients.We examined HIF-1α expression in sinonasal tissues from CRSwNP patients and healthy controls by using immunohistochemistry, qRT-PCR, and western blot. Next, the stimulatory effects of several cytokines (IFN-γ, IL-17A, IL-6, etc.) and reagents (dexamethasone (DEX), clarithromycin (CAM) and curcumin (CUM)) on HIF-1α expression in cultured normal nasal epithelial cells (NECs) were also evaluated. Moreover, the effects of CAM and glucocorticoid on nasal symptoms and signs of uncontrolled neutrophilic CRSwNP patients were evaluated.The mRNA and protein expression of HIF-1α were significantly increased in polyp tissues compared with healthy controls (P 0.05), and the HIF-1α level in polyp tissues was positively associated with IL-17A production and tissue neutrophilia (P 0.05). Moreover, in cultured NECs, HIF-1α expression was upregulated in the presence of IL-17A and IL-6 (P 0.05). Both CAM and CUM showed an additive effect with DEX in inhibiting HIF-1α expression (P 0.05). Moreover, combined glucocorticoid and CAM significantly improved nasal symptoms and signs compared with glucocorticoid alone in uncontrolled neutrophilic CRSwNP patients (P 0.05).Our findings indicate that HIF-1α is associated with neutrophilic inflammation and glucocorticoid resistance in CRSwNP patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56dc93ee01062e48f445ab60992864f6Test
https://doi.org/10.1016/j.anl.2019.09.011Test

2

Intrauterine fetoscopic laser surgery versus expectant management in stage 1 twin-to-twin transfusion syndrome

المؤلفون: Mona Massoud, Anthony Johnson, Nahla Khalek, Philippe Aegerter, Julien Stirnemann, Laurence Bussières, Marie-Victoire Senat, Femke Slaghekke, Liesbeth Lewi, Kurt Hecher, Yves Ville, Norbert Winer

المساهمون: CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Fédération pour la recherche en explorations et thérapeutiques innovantes in utéro (FETUS (URP 7328)), Université de Paris (UP), Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre hospitalier universitaire de Nantes (CHU Nantes), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Laboratoire des mécanismes réactionnels (DCMR), École polytechnique (X)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)

المصدر: American Journal of Obstetrics and Gynecology, 224(5), 528.e1-528.e12. MOSBY-ELSEVIER
American Journal of Obstetrics and Gynecology
American Journal of Obstetrics and Gynecology, Elsevier, 2021, 224 (5), pp.1-12. ⟨10.1016/j.ajog.2020.11.031⟩

مصطلحات موضوعية: Laser surgery, Fetal Membranes, Premature Rupture, Polyhydramnios, Percutaneous, medicine.medical_treatment, 0302 clinical medicine, Pregnancy, Risk Factors, randomized trial, 030212 general & internal medicine, fetal surgery, Quintero stage 1, Laser Coagulation, 030219 obstetrics & reproductive medicine, Obstetrics and Gynecology, Fetofetal Transfusion, multifetal gestation, 3. Good health, Survival Rate, monochorionic twins, Disease Progression, Female, Monochorionic twins, medicine.symptom, PPROM, Laser coagulation, Adult, medicine.medical_specialty, [SDV.MHEP.GEO]Life Sciences [q-bio]/Human health and pathology/Gynecology and obstetrics, Twin-to-twin transfusion syndrome, Asymptomatic, Ultrasonography, Prenatal, anastomoses, 03 medical and health sciences, medicine, Humans, Watchful Waiting, fetoscopic surgery, Fetal surgery, business.industry, Fetoscopy, Infant, preterm birth, medicine.disease, Surgery, laser ablation, Quintero, Nervous System Diseases, fetal death, business

الوصف: BACKGROUND: Selective fetoscopic laser coagulation of the intertwin anastomotic chorionic vessels is the first-line treatment for twin-twin transfusion syndrome. However, in stage 1 twin-twin transfusion syndrome, the risks of intrauterine surgery may be higher than those of the natural progression of the condition. OBJECTIVE: This study aimed to compare immediate surgery and expectant follow-up in stage 1 twin-twin transfusion syndrome. STUDY DESIGN: We conducted a multicentric randomized trial, which recruited from 2011 to 2018 with a 6-month postnatal follow-up. The study was conducted in 9 fetal medicine centers in Europe and the Unites States. Asymptomatic women with stage 1 twin-twin transfusion syndrome between 16 and 26 weeks' gestation, a cervix of >15 mm, and access to a surgical center within 48 hours of diagnosis were randomized between expectant management and immediate surgery. In patients allocated to immediate laser treatment, percutaneous laser coagulation of anastomotic vessels was performed within 72 hours. In patients allocated to expectant management, a weekly ultrasound follow-up was planned. Rescue fetoscopic coagulation of anastomoses was offered if the syndrome worsened as seen during a follow-up, either because of progression to a higher Quintero stage or because of the maternal complications of polyhydramnios. The primary outcome was survival at 6 months without severe neurologic morbidity. Severe complications of prematurity and maternal morbidity were secondary outcomes. RESULTS: The trial was stopped at 117 of 200 planned inclusions for slow accrual rate over 7 years: 58 women were allocated to expectant management and 59 to immediate laser treatment. Intact survival was seen in 84 of 109 (77%) expectant cases and in 89 of 114 (78%) (P=.88) immediate surgery cases, and severe neurologic morbidity occurred in 5 of 109 (4.6%) and 3 of 114 (2.6%) (P=.49) cases in the expectant and immediate surgery groups, respectively. In patients followed expectantly, 24 of 58 (41%) cases remained stable with dual intact survival in 36 of 44 (86%) cases at 6 months. Intact survival was lower following surgery than for the nonprogressive cases, although nonsignificantly (78% and 71% following immediate and rescue surgery, respectively). CONCLUSION: It is unlikely that early fetal surgery is of benefit for stage 1 twin-twin transfusion syndrome in asymptomatic pregnant women with a long cervix. Although expectant management is reasonable for these cases, 60% of the cases will progress and require rapid transfer to a surgical center. ispartof: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY vol:224 issue:5 ispartof: location:United States status: published

وصف الملف: application/pdf; Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b25e749a19d171d7c65fe0dd16e852Test
https://hdl.handle.net/1887/3279913Test

3

Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy

المؤلفون: Adam Dungey, Joshua S. Speed, London J Williams, Kenneth D. Vick, Haley N. Jenkins, Bernadette E. Grayson

المصدر: Surg Obes Relat Dis

الوصف: Background Obesity and insulin resistance are positively correlated with plasma endothelin-1 (ET-1) levels; however, the mechanisms leading to increased ET-1 are not understood. Similarly, the full physiological complexity of ET-1 has yet to be described, especially in obesity. To date, one of the best treatments available for morbid obesity is bariatric surgery to quickly reduce body fat and the factors associated with obesity-related disease; however, the effects of vertical sleeve gastrectomy (SG) on plasma ET-1 have not been described. Objectives To determine if SG will reduce plasma ET-1 levels and to determine if plasma ET-1 concentration is associated with weight loss after surgery. Setting The studies were undertaken at a University Hospital. Methods This was tested by measuring plasma ET-1 levels from 12 obese patients before and after SG. All data were collected from clinic visits before SG, 6 weeks after SG, and 6 months after surgery. Results At 6 weeks after SG, plasma ET-1 levels increased by 24%; however, after 6 months, there was a 27% decrease compared with presurgery. Average weight loss in this cohort was 11.3% ± 2.4% body weight after 6 weeks and 21.4% ± 5.7% body weight after 6 months. Interestingly, we observed an inverse relationship between baseline plasma ET-1 and percent body weight loss (R2 = .49, P = .01) and change in body mass index 6 months (R2 = .45, P = .011) post bariatric surgery. Conclusions Our results indicate that SG reduces plasma ET-1 levels, a possible mechanism for improved metabolic risk in these patients. These data also suggest that ET-1 may serve as a predictor of weight loss after bariatric surgery.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da39922b40f00a0464feed8aa0fda6e8Test
https://doi.org/10.1016/j.soard.2019.03.047Test

4

Important Role of the GLP-1 Axis for Glucose Homeostasis after Bariatric Surgery

المؤلفون: Kathleen Davy, Andrew B. Leiter, Audrey Melvin, Anne K. McGavigan, Joyce Li, Richard H. Hardwick, Geoffrey P. Roberts, Emma K. Biggs, Richard G. Kay, Giles S.H. Yeo, Peter Ravn, Fiona M. Gribble, David C. Hornigold, Pierre Larraufie, Frank Reimann

المساهمون: Wellcome Trust-MRC Institute of Metabolic Science, Larraufie, Pierre [0000-0001-7718-6200], Kay, Richard [0000-0002-3827-8687], Yeo, Giles [0000-0001-8823-3615], Reimann, Frank [0000-0001-9399-6377], Gribble, Fiona [0000-0002-4232-2898], Apollo - University of Cambridge Repository

المصدر: Cell Reports, Vol 26, Iss 6, Pp 1399-1408.e6 (2019)
Cell Reports
Cell Reports, Elsevier Inc, 2019, 26 (6), pp.1399-1408.e6. ⟨10.1016/j.celrep.2019.01.047⟩

مصطلحات موضوعية: Male, gut hormones, medicine.medical_treatment, Enteroendocrine cell, Type 2 diabetes, Mice, transcriptomics, Weight loss, intestinal transit, Glucagon-Like Peptide 1, Insulin Secretion, Glucose homeostasis, Homeostasis, Insulin, Postoperative Period, Intestinal Mucosa, 050207 economics, Receptor, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, mass spectrometry, 050208 finance, 05 social sciences, digestive, oral, and skin physiology, Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, 3. Good health, Female, medicine.symptom, hormones, hormone substitutes, and hormone antagonists, Adult, medicine.medical_specialty, endocrine system, bariatric surgery, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Article, 0502 economics and business, medicine, Animals, Hypoglycemic Agents, Humans, Peptide YY, Secretion, Obesity, enteroendocrine cells, business.industry, peptidomics, medicine.disease, Peptide Fragments, Surgery, Mice, Inbred C57BL, Glucose, lcsh:Biology (General), Transcriptome, business, GLP-1

الوصف: Summary Bariatric surgery is widely used to treat obesity and improves type 2 diabetes beyond expectations from the degree of weight loss. Elevated post-prandial concentrations of glucagon-like peptide 1 (GLP-1), peptide YY (PYY), and insulin are widely reported, but the importance of GLP-1 in post-bariatric physiology remains debated. Here, we show that GLP-1 is a major driver of insulin secretion after bariatric surgery, as demonstrated by blocking GLP-1 receptors (GLP1Rs) post-gastrectomy in lean humans using Exendin-9 or in mice using an anti-GLP1R antibody. Transcriptomics and peptidomics analyses revealed that human and mouse enteroendocrine cells were unaltered post-surgery; instead, we found that elevated plasma GLP-1 and PYY correlated with increased nutrient delivery to the distal gut in mice. We conclude that increased GLP-1 secretion after bariatric surgery arises from rapid nutrient delivery to the distal gut and is a key driver of enhanced insulin secretion.
Graphical Abstract
Highlights • Increased postprandial GLP-1 triggers higher insulin levels after bariatric surgery • Bariatric surgery does not change enteroendocrine cell identity or hormone content • Increased nutrient flow to the distal gut after surgery enhances GLP-1 secretion
Bariatric surgery is associated with enhanced postprandial gut hormone release, particularly of GLP-1, which increases insulin secretion and glucose clearance. Larraufie et al. show that higher gut hormone levels are due not to changes in enteroendocrine cell characteristics or tissue hormone content but to altered flow of nutrients that stimulates more distal enteroendocrine cells.

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae54233a151a0b071cd3248fbe10f856Test
http://www.sciencedirect.com/science/article/pii/S2211124719300658Test

5

Preformed Angiotensin II Type-1 Receptor Antibodies Are Associated With Rejection After Kidney Transplantation: A Single-Center, Cohort Study

المؤلفون: Nicolae Leca, R. Bakthavatsalam, Lena Sibulesky, K. Nelson, D. Kim, I. Gimferrer, P. Warner

المصدر: Transplantation Proceedings. 50:3467-3472

الوصف: Antibodies against angiotensin II type-1 receptors (AT1R) have been increasingly recognized in association with rejection and poor allograft outcomes. Our goal was to define the prevalence of preformed antibodies against AT1R and evaluate the association with renal allograft outcomes in a consecutive cohort of 150 transplant recipients. IgG antibodies against AT1R were measured by enzyme-linked immunosorbent assay using cryopreserved serum samples obtained for HLA testing at the time of transplantation. Results were categorized as negative if 10 U/mL (44%), intermediate from 10 to 17 U/mL (38%), or strongly positive if17 U/mL (18%). The presence of AT1R antibodies was inversely associated with age, dialysis status, and diabetes. We found a strong association between the presence of AT1R antibodies and acute cellular rejection using multivariate analyses, odds ratio 3.86 (95% CI, 1.03-14.47) for intermediate titers and 9.99 (95% CI, 2.6-38.4) for strongly positive titers. There was no association with HLA sensitization or C4d-positive antibody-mediated rejection. We did not observe a significant association with graft failure, allograft function, or proteinuria. Preformed AT1R antibodies are prevalent and highly associated with acute cellular rejection early after transplant, independent of anti-HLA antibodies. The presence of AT1R antibodies correlates with recipient characteristics that may denote stronger immune responses. Future studies are needed to evaluate the mechanism and causative effect of AT1R antibodies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c750e04becab7f74f68b323bb6c878Test
https://doi.org/10.1016/j.transproceed.2018.05.022Test

6

Hyperbaric oxygen therapy improves the effect of keloid surgery and radiotherapy by reducing the recurrence rate

المؤلفون: Shu Liu, Xin-Hang Dong, Wei-zhong Liang, Kexin Song, Xiaojun Wang, Mingzi Zhang, Youbin Wang, Hao Liu

المصدر: Journal of Zhejiang University-SCIENCE B. 19:853-862

مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, 0301 basic medicine, medicine.medical_specialty, Adolescent, medicine.medical_treatment, H&E stain, Scars, Article, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Keloid, Hyperbaric oxygen, Recurrence, Surveys and Questionnaires, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Inflammation, Hyperbaric Oxygenation, General Veterinary, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, NF-kappa B p50 Subunit, General Medicine, Middle Aged, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Surgery, Perfusion, Radiation therapy, Vascular endothelial growth factor, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Tumor necrosis factor alpha, medicine.symptom, business

الوصف: Objective: Keloids are exuberant cutaneous scars that form due to abnormal growth of fibrous tissue following an injury. The primary aim of this study was to assess the efficacy and mechanism of hyperbaric oxygen therapy (HBOT) to reduce the keloid recurrence rate after surgical excision and radiotherapy. Methods: (1) A total of 240 patients were randomly divided into two groups. Patients in the HBOT group (O group) received HBOT after surgical excision and radiotherapy. Patients in the other group were treated with only surgical excision and radiotherapy (K group). (2) Scar tissue from recurrent patients was collected after a second operation. Hematoxylin and eosin (H&E) staining was used to observe keloid morphology. Certain inflammatory factors (interleukin-6 (IL-6), hypoxia-inducible factor-1α (HIF-1α), tumor necrosis factor-α (TNF-α), nuclear factor κB (NF-κB), and vascular endothelial growth factor (VEGF)) were measured using immunohistochemical staining. Results: (1) The recurrence rate of the O group (5.97%) was significantly lower than that of the K group (14.15%), P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9e0ed7e7fdfd4c5d351c7074e87a27Test
https://doi.org/10.1631/jzus.b1800132Test

7

National Trends in Spinal Fusion Surgery for Neurofibromatosis

المؤلفون: Etka Kurucan, Caroline P. Thirukumaran, Amit Jain, David N. Bernstein, Emmanuel N. Menga, Addisu Mesfin, Paul T. Rubery

المصدر: Spine Deformity. 6:712-718

الوصف: Analysis of a national database. To analyze trends in spinal fusion surgery for neurofibromatosis type I (NF-1) patients and to compare the surgical approaches. The preferred surgical approach for fusion treatment of spinal deformity in NF is not well established. We identified 548 patients with a diagnosis of NF-1 who had received spinal fusion surgery between 2003 and 2014. We compared posterior spinal fusion (PSF), anterior-posterior spinal fusion (APSF), and anterior spinal fusion with respect to patient demographics, institutional characteristics, in-hospital complications, and hospitalization lengths and costs. Significance was set at a value of p less than .05. The number of spinal fusions for NF-1 significantly increased (p = .02) over the study period. The rate of PSF surgeries increased 2.9-fold, whereas the rate of APSF surgeries decreased 2.2-fold. There was also a significant association between the location of the fusion and surgical approach (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afb16794c7683e65e34ab1b42aeaf24Test
https://doi.org/10.1016/j.jspd.2018.03.012Test

8

Simultaneous Supratentorial and Infratentorial Pilocytic Astrocytomas in an Adult Patient with Concurrent Neurofibromatosis Type 1 and HIV Infection

المؤلفون: Carlos Pontinha, Manuela Mafra, Dalila Forte, Luís Mateus, Anabela Nabais

المصدر: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

الوصف: BACKGROUND: Neurofibromatosis type 1 (NF1) has been identified as a predisposing factor in the development of pilocytic astrocytoma (PA), a common benign central nervous system tumor. Although this is a common association, simultaneous development of multiple lesions is an infrequent finding, especially in nonoptic and hypothalamic locations. CASE DESCRIPTION: A 41-year-old female patient with NF1 and uncontrolled human immunodeficiency virus (HIV) type 1 infection presented with a first generalized seizure and associated headache and ataxia. Imaging studies revealed 2 large intra-axial PAs, nodular-cystic in the supratentorial compartment and solid in the infratentorial compartment. Both lesions were treated by gross total resection in 2 surgeries performed 1 week apart. Despite their different imaging patterns, the tumors were histologically and genetically identical. CONCLUSIONS: We present a unique case involving 2 histologically and genetically identical PAs occurring simultaneously in supratentorial and infratentorial locations. We suggest that an intrinsic predisposition to tumor development in patients with NF1 might have been enhanced by the HIV-related immunosuppression in this case. Strict oncologic surveillance is essential in patients with a tumor predisposition syndrome combined with immunosuppression. info:eu-repo/semantics/publishedVersion

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beebba6ea843407d70b37315e9ef6604Test
https://doi.org/10.1016/j.wneu.2018.06.011Test

9

Presentation and Outcomes of Antibody-Mediated Rejection Associated With Angiotensin II Receptor 1 Antibodies Among Kidney Transplant Recipients

المؤلفون: Mary Carmelle Philogene, Nada Alachkar, Sami Alasfar, Yousuf Kyeso, Mohammad Abuzeineh

المصدر: Transplantation proceedings. 53(5)

الوصف: Background It remains challenging to manage antibody-mediated rejection (ABMR) associated with angiotensin II type 1 receptor antibodies (AT1R-Abs) in kidney transplant recipients and the outcomes are not well defined. We describe the presentation, clinical course, and outcomes of this condition. Methods This retrospective study included kidney transplant recipients with AT1R-Ab levels ≥10 units/mL and biopsy-proven ABMR in the absence of significant HLA-donor-specific antibodies at the time of rejection. Results We identified 13 recipients. Median creatinine (Cr) at rejection was significantly higher (2.05 mg/dL) compared with baseline (1.2 mg/dL), P = .006. After ABMR management, the difference in median Cr was not significant (1.5 mg/dL), P = .152. Median AT1R-Ab level was higher in the pretransplant sample (34.5 units/mL) compared with the level at rejection (19 units/mL) and after rejection treatment (13 units/mL); however, these differences were not significant, P = .129. Eight of the 13 recipients received antibody reduction therapy with plasmapheresis and intravenous immunoglobulin, and 5 of the 13 recipients had other therapies. After rejection management, 6 of the 13 recipients had improvement in Cr to baseline and 7 of the 13 recipients had > 50% reduction in proteinuria. Conclusions AT1R-Ab–associated ABMR management and outcomes depend on the clinical presentation and may include antibody-reducing therapies among other therapies. Further prospective cohorts will improve recognizing and managing this condition.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd4db261f50d4edf5af373d7a04a984bTest
https://pubmed.ncbi.nlm.nih.gov/33573814Test

10

How Diluted Liquid Sodium Tetradecyl Sulphate Works in Varices with Competent Superficial Valves Versus Stockings Alone

المؤلفون: Elham Zangeneh Yousefabadi, Seyed Mansour Alamshah

المصدر: Pakistan journal of biological sciences : PJBS. 23(8)

الوصف: BACKGROUND AND OBJECTIVE Varicose veins are the most common complaints of referrals to vascular surgeons. Upon the cause, liquid sclerotherapy could be an efficient solution first in regard to competent main superficial valves. To find the impact of diluted liquid sclerotherapy in varices in patients with no superficial valve refluxes compare to whom wearing only stockings. MATERIALS AND METHODS Sclerotherapy with 0.3-0.5% liquid form of Sodium Tetradecyl Sulphate (STS) for reticular and spider varicosis, ulcers feeder veins and grade 3-4 sporadic varices were used. Patient's complaints the zone prevalence, response and satisfactoriness were detected clinically and data compared between the two injected cases and who managed by stockings alone with >1 year follow up. RESULTS Two groups (156 sclerotherapy, 76 only stockings) with three classifications for severity were obtained. Complete recovery of all varices and ulcers were almost achieved with no considerable complication. Logical regression test in unilateral to bilateral varices predict about 70% more recovery (p = 0.048), mild to severe 85% more (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55acf98242f7a7c7af131673d15ffa2fTest
https://pubmed.ncbi.nlm.nih.gov/32700852Test

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