نتائج البحث

1

Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding

المؤلفون: Yvon C. Chagnon, G. Sun, Claude Bouchard, André J. Tremblay, Olavi Ukkola

المصدر: European Journal of Clinical Nutrition. 55:1008-1015

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Thyroid Hormones, Genetic Linkage, Medicine (miscellaneous), Clinical nutrition, Biology, Polymerase Chain Reaction, Ion Channels, Mitochondrial Proteins, Thyroid-stimulating hormone, Internal medicine, medicine, Uncoupling protein, Humans, Uncoupling Protein 3, Uncoupling Protein 2, Obesity, Uncoupling Protein 1, UCP3, Nutrition and Dietetics, Uncoupling Agents, Genetic Variation, Membrane Proteins, Membrane Transport Proteins, Proteins, Twins, Monozygotic, Thermogenin, Respiratory quotient, Endocrinology, Basal metabolic rate, Body Composition, Basal Metabolism, medicine.symptom, Carrier Proteins, Energy Intake, Energy Metabolism, Weight gain, Polymorphism, Restriction Fragment Length

الوصف: Objective: To evaluate the effects of uncoupling protein (UCP) 1, UCP2 and UCP3 gene variants on body composition and metabolic changes in response to chronic overfeeding and the recovery after the period of overfeeding. Subjects and design: Twenty-four normal weight men (21±2 y), who constituted 12 pairs of identical twins, ate a 4.2 MJ/day energy surplus, 6 days a week, during a period of 100 days. The subjects were asked to return to the laboratory for testing at 4 months and for a final examination 5 y after completion of the overfeeding protocol. Methods: Resting metabolic rate (RMR) measurements were performed before and after overfeeding. A 4.2 MJ test meal was consumed, after which calorimetric measurements were continued for 240 min. Total body fat was assessed by hydrodensitometry and total subcutaneous fat by the sum of eight skinfolds. Polymorphisms were typed by PCR and PCR-RFLP-techniques. Thyroid stimulating hormone (TSH) concentrations after a thyrotropin releasing hormone (TRH) injection were measured by radioimmunoassay (RIA). Results: The changes in body weight and adiposity were not different between UCP1 Bcl I, UCP2 alanine to valine (A55V), UCP2 insertion/deletion (I/D) or UCP3 Rsa I genotypes. However, the recovery from overfeeding was worse among G-allele carriers of the UCP1 Bcl I, I allele non-carriers of the UCP2 I/D, AV heterozygote subjects of the UCP2 A55V and CC subjects of the UCP3 Rsa I polymorphisms. RMR was lower both before (P=0.01) and after (P=0.001) overfeeding in subjects with the CC genotype of the UCP3 Rsa I polymorphism. Moreover, after overfeeding, the UCP2 A55V heterozygote and UCP3 Rsa I CC homozygote subjects had significantly higher respiratory quotient (RQ) values at rest (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3beb5f5760f9c01e99d59471069ecf1Test
https://doi.org/10.1038/sj/ejcn/1601261Test

2

Diabetic ketoacidosis: a canary in the mine for mental health disorders?

المؤلفون: Cheryl Steele, Azni L Abdul-Wahab, Sylvia Xu, P. S. Hamblin, Sara Vogrin

المصدر: Internal Medicine Journal. 52:1002-1008

الوصف: BACKGROUND: Recurrent diabetic ketoacidosis (DKA) has been linked to mental health disorders, but less is known about single DKA episodes. Most studies are retrospective, lacking control groups. AIMS: Prospectively examine psychosocial factors in patients presenting with recurrent or single episode DKA and compare to people who have not had DKA. METHODS: Case-controlled study (consecutive adult DKA admissions April 2015 to December 2016) at Western Health, Melbourne. Data were prospectively collected regarding: diagnosed mental health disorders, likely depression (PHQ-9 questionnaire), diabetes distress (PAID questionnaire) and presence of adverse social factors. A control group without a history of DKA was also recruited. RESULTS: Of 123 patients admitted with DKA (164 consecutive episodes), 70 consented to participate and 73 age matched type 1 diabetes controls were recruited. Eleven of 18 (61%) with recurrent DKA had a diagnosed mental health disorder, versus 8 of 42 (19%) in the single episode group (p=0.016). The prevalence of likely depression using PHQ-9 was: recurrent 50%, single 40% and controls 22% (recurrent vs controls, p=0.036, single vs controls, p=0.053). Severe diabetes distress (PAID) was present in 47% of recurrent and 34% of single episode DKA (p=0.387). As a group, DKA patients had significantly more unemployment, illicit drug use and tobacco smoking, a lower level of formal education and less regular medical contact compared to controls. CONCLUSIONS: Mental health disorders and adverse socio-economic factors appear to be common in patients with DKA. The diagnosis of DKA presents an excellent opportunity to screen for depression and offer appropriate intervention. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7ca1798df3ded6255204d7dae29a97Test
https://doi.org/10.1111/imj.15214Test

3

Superior Mesenteric Artery Syndrome Accompanied by Acute-onset Type 1 Diabetes Complicated with Graves' Disease

المؤلفون: Eijiro Yamada, Yasuyo Nakajima, Emi Ishida, Satoshi Yoshino, Shuichi Okada, Kazuhiko Horiguchi, Shunichi Matsumoto, Mai Sue-Nagumo, Masanobu Yamada

المصدر: Internal Medicine. 61:1555-1560

الوصف: A 35-year-old man experienced general fatigue and could not eat solid food because of nausea and vomiting. His weight abruptly decreased from 49 to 45 kg after 2 weeks. A detailed examination indicated superior mesenteric artery syndrome (SMAS) accompanied by acute-onset type 1 diabetes complicated by Graves' disease, referred to as autoimmune polyglandular syndrome type 3A (APS3A). Although SMAS has a good prognosis, some cases require emergency surgery, especially when complicated by gastric perforation. In our case, APS3A and SMAS developed rapidly and at approximately the same time, resulting in a cycle of mutual exacerbation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f59ada3f465d5c49610b5ffca899b8Test
https://doi.org/10.2169/internalmedicine.8364-21Test

4

Relationship between soluble protein ST2 (sST2) levels and microvascular complications in a cohort of patients with type 1 diabetes

المؤلفون: Ibai Tamayo, Luis Forga, María José Goñi, Marta García-Mouriz, Natalia López-Andrés, Amaya Fernández-Celis

المصدر: Endocrinología, Diabetes y Nutrición. 69:322-330

الوصف: Aim To determine the association and the prognostic value of soluble ST2 (sST2) levels in the development of diabetic retinopathy (DR), diabetic macular oedema (DMO) or diabetic nephropathy (DN), in a cohort of patients with type 1 diabetes (T1D). Methods A total of 269 individuals with T1D (154 males and 115 females) were recruited. The overall mean age was 43.2 ± 14.9 years, and the diabetes duration was 17.1 ± 12.1 years. Levels of sST2 in serum were evaluated, and the presence as well as the degree of DR, DMO and DN was recorded. Additionally, other clinical and analytical parameters including demographic variables were recovered from patients’ electronic health record. Ten years later, the presence and stage of DR, DMO and DN were again recorded under the same criteria. The association between previously mentioned parameters with DR and DN was analysed by univariate and multivariate logistic regression. The variables in the final multivariate models were adjusted from complete models via backward elimination and maintained only when significant. Results An increase of 10 ng/ml in the levels of sST2 was associated with a 1.50 (1.02–2.19) and 1.48 (1.05–2.08) prevalence odds ratio (OR) in DMO and DR, respectively. There was no association between sST2 levels and DN. Meanwhile, sST2 levels did not display a prognostic effect in any of the microangiopathic diabetic complications studied. Conclusions Levels of sST2 are associated with the presence of DR and DMO, they do not seem to be predictive for the development or deterioration of DR, DMO or DN.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39145ca401098d175ad8714f42307885Test
https://doi.org/10.1016/j.endinu.2021.05.007Test

5

Association between pheochromocytoma and neurofibromatosis type I: a rare entity in the African population

المؤلفون: Brandon Spencer Jackson, Daniel Montwedi, Maryke De Villiers

المصدر: BMJ Case Rep

الوصف: The association of pheochromocytoma in patients with neurofibromatosis type I has rarely been reported in low-income countries, especially on the African continent. A 43-year-old woman with neurofibromatosis type I was diagnosed with a right adrenal pheochromocytoma in Pretoria, South Africa. To our knowledge, this report is the first case to be published of a patient with neurofibromatosis type I diagnosed with a pheochromocytoma in Pretoria, and one of three cases on the African continent. The rarity may be due to the two associated conditions being under-reported, undiagnosed, misdiagnosed or possibly the association is rare on the African continent. The clinician dealing with these two conditions should be aware of the association.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eb66e16cecc47edf0ff7fff0734e3cTest
https://pubmed.ncbi.nlm.nih.gov/33972293Test

6

A Nonrandomized Pilot of a Group, Video-Based Telehealth Intervention to Reduce Diabetes Distress in Parents of Youth With Type 1 Diabetes Mellitus

المؤلفون: Mark A. Clements, Alexandra D. Monzon, Arwen M. Marker, Susana R. Patton

المصدر: Can J Diabetes

الوصف: Our aim in this study was to refine and pilot a video-based telehealth intervention to reduce diabetes distress, depressive symptoms and hypoglycemia fear in parents of school-age children with type 1 diabetes and to assess for changes in child glycated hemoglobin (A1C).We recruited 41 parents of children (5 to 12 years) to participate in a manualized, video-based telehealth intervention (Cognitive Adaptions to Reduce Emotional Stress [CARES]). Of these, 29 parents completed either a 12-week (n=13) or 8-week (n=16) version of CARES based on the timing of their recruitment. We assessed feasibility (i.e. attrition, attendance) and parent satisfaction with CARES. We used repeated-measures analysis of variance with parent group (8 vs 12 sessions) as a between-subject variable and time as a within-subject variable to measure change in our dependent variables.Mostly mothers participated (97.3%). Parents' mean age was 39.65±6.84 years and children's mean age was 9.86±1.57 years at pretreatment. CARES had low attrition (20% to 25%) and good attendance (96% to 98%). Parents also reported high levels of treatment satisfaction (85%). There were significant main effects for time for parent-reported diabetes distress and depressive symptoms at posttreatment and 3-month follow-up. There was a statistical trend suggesting a time × group interaction for parent depressive symptoms at posttreatment. There was a significant main effect for time for hypoglycemia fear at the 3-month follow-up but no change at posttreatment. There was no change in child A1C at posttreatment.CARES showed high parent satisfaction, good feasibility and promising results for reducing diabetes distress in parents of school-age children with type 1 diabetes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28e64ca0b105429e428e5d0935993a5Test
https://doi.org/10.1016/j.jcjd.2021.10.007Test

7

Six-Month Glycemic Control with a Hybrid Closed-Loop System in Type 1 Diabetes Patients in a Latin American Country

المؤلفون: María Laura Kabakian, Marcela Raggio, Adrián Proietti, Antonio Saleme, Maria Paula Paz, Graciela Rubin, Luis Grosembacher

المصدر: Diabetes Technology & Therapeutics. 24:220-226

الوصف: The goal of this study was to assess the 6-months effectiveness of HCL on glycemic control in T1D patients in Latin America. An exploratory analysis of data prospectively collected from non-selected consecutive patients with T1D that initiated treatment with MiniMed™ 670G system in Argentina was conducted. Baseline and follow up visits at days 7, 28, 90 and 180 days were carried out and data was downloaded in each visit. A total of 30 patients were included (age range 9-57), female 63.3%, previous use of SAP-PLGM 73.3% (n=22), baseline HbA1c 7.4 ± 1%. Time in range (TIR) between 70-180 mg/dl significantly increased from 65.1% at baseline to 77.3%, 76.2%, 75.7%, and 75,2% at days 7, 28, 90 and 180 respectively. Time above range (>180 mg/dL) statistically significantly decreased from 33% to 22.5% (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaf7894b4768461fc82cc79e0343a30Test
https://doi.org/10.1089/dia.2021.0248Test

8

Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes

المصدر: Diabetes Technology & Therapeutics. 24:178-189

الوصف: Introduction: This trial assessed safety and effectiveness of an advanced hybrid closed-loop (AHCL) system with automated basal (Auto Basal) and automated bolus correction (Auto Correction) in adol...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0139095a17c711398f86d1cf4cb966Test
https://doi.org/10.1089/dia.2021.0319Test

9

Is there a role for bariatric surgery in patients with severe obesity and type 1 diabetes?

المؤلفون: Mustapha Daouadi, Craig Wood, David M. Parker, Dylan Carmichael, Anthony T. Petrick, Brian Dessify

المصدر: Surgery for Obesity and Related Diseases. 18:177-181

الوصف: Background The prevalence of obesity in type I diabetes mellitus has been increasing over the past decades. Multiple studies have demonstrated suboptimal outcomes with dietary control and medical management for obesity and diabetes mellitus type II. This study's objective was to evaluate insulin and diabetic medication requirements in patients with type I diabetes mellitus two years after bariatric surgery. Methods This was a retrospective chart review study from 2002-2019 at Geisinger health system. Of 4549 total bariatric surgeries, 38 bariatric surgery patients were confirmed to have type I diabetes mellitus. Type I diabetes mellitus was confirmed by chart review and/or presence of c-peptide Results The patient cohort had a mean age of 41 years, with 87% being female. The mean BMI was 43.0, with a mean Hb A1c of 8.4% before surgery. During follow-up the insulin requirements improved from 114 units preoperatively to 60 units at 1 year postoperatively (SD= 54.5, p= 0.0018) and 60 units at 2-years postoperatively (SD= 60.3, p= 0.0033). Though not significant, the number of patients on more than one diabetic medication decreased from 66% preoperatively to 53% 1-year postoperatively (p=0.343) and 52% at 2-years (p=0.149). Discussion This study demonstrated significant improvement in the insulin and the total number of diabetic medication requirements after bariatric surgery, suggesting that bariatric surgery may be a viable treatment within patients that have type I diabetes mellitus.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297fe439cd862e74f1ac7a0431f8bc14Test
https://doi.org/10.1016/j.soard.2021.10.013Test

10

Anti-AT1R autoantibodies and prediction of the severity of Covid-19

المؤلفون: Carla Cervelli, Franco Marinangeli, Anna Cecilia Carucci, Alessandro Grimaldi, Vincenza Cofini, Chiara Angeletti, Stefano Necozione, Franco Papola, Veronica Biancofiore, Alessia Rosciano

المصدر: Human Immunology

مصطلحات موضوعية: Adult, Male, Angiotensin II, AT1R autoantibodies, SARS-CoV-2 infection, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Short Communication, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Stimulation, Autoantigens, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Gastroenterology, Receptor, Angiotensin, Type 1, Internal medicine, medicine, Humans, Immunology and Allergy, Respiratory system, AngII, Angiotensin II, Aged, Autoantibodies, Retrospective Studies, Aged, 80 and over, Angiotensin II receptor type 1, SARS-CoV-2, business.industry, Autoantibody, COVID-19, General Medicine, Middle Aged, medicine.disease, ACE-2, Angiotensin Converting Enzyme, Hospitalization, Italy, Female, business, Cytokine storm, AT1Rab, autoantibodies direct vs Angiotensin II Receptor1

الوصف: The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6. This pro-inflammatory action stimulate the cytokine storm that characterizes the most severe forms of SARS-CoV-2 infection. We studied the effect of AT1Rab on the AT1R on 74 subjects with SARS-CoV-2 infection with respiratory symptoms requiring hospitalization. We divided the patients into 2 groups: 34 with moderate and 40 with severe symptoms that required ICU admission. Hospitalized subjects showed a 50% reduction in the frequency of AT1Rab compared to healthy reference population. Of the ICU patients, 33/40 (82.5%) were AT1Rab negative and 16/33 of them (48.5%) died. All 7 patients positive for AT1Rab survived. These preliminary data seem to indicate a protective role played by AT1R autoantibodies on inflammatory activation in SARS-CoV-2 infection pathology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072859fa313f38d2ce140b2f398e7d77Test
https://doi.org/10.1016/j.humimm.2021.10.006Test

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