التفاصيل البيبلوغرافية
| العنوان: |
Association of Hepatitis C With Markers of Hemostasis In HIV-Infected and Uninfected Women in the Women's Interagency HIV Study (WIHS) |
| المؤلفون: |
Kiefer, Elizabeth M, Shi, Qiuhu, Hoover, Donald R, Kaplan, Robert, Tracy, Russell, Augenbraun, Michael, Liu, Chenglong, Nowicki, Marek, Tien, Phyllis C, Cohen, Mardge, Golub, Elizabeth T, Anastos, Kathryn |
| المصدر: |
JAIDS Journal of Acquired Immune Deficiency Syndromes, vol 62, iss 3 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2013 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Medical Microbiology, Biomedical and Clinical Sciences, Immunology, Chronic Liver Disease and Cirrhosis, Infectious Diseases, Clinical Research, HIV/AIDS, Digestive Diseases, Hematology, Liver Disease, Hepatitis, Emerging Infectious Diseases, Hepatitis - C, Infection, Good Health and Well Being, Adult, Biomarkers, Coinfection, Cross-Sectional Studies, Factor VIII, Female, Fibrin Fibrinogen Degradation Products, HIV Infections, Hemostasis, Hepatitis C, Humans, Plasminogen Activator Inhibitor 1, Prospective Studies, Protein S, Regression Analysis |
| جغرافية الموضوع: |
301 - 310 |
| الوصف: |
BackgroundCoinfection with HIV and hepatitis C virus (HCV) is common. HIV infection and treatment are associated with hypercoagulability; thrombosis in HCV is underinvestigated. Proposed markers of hemostasis in HIV include higher D-dimer, Factor VIII%, and plasminogen activator inhibitor-1 (PAI-1) antigen and lower total Protein S% (TPS) but have not been examined in HCV. We assessed the independent association of HCV with these 4 measures of hemostasis in a multicenter, prospective study of HIV: the Women's Interagency HIV Study.MethodsWe randomly selected 450 HCV-infected (anti-HCV+ with detectable plasma HCV RNA) and 450 HCV-uninfected (anti-HCV-) women. HCV was the main exposure of interest in regression models.ResultsFour hundred forty-three HCV+ and 425 HCV- women were included. HCV+ women had higher Factor VIII% (124.4% ± 3.9% vs. 101.8% ± 3.7%, P < 0.001) and lower TPS (75.7% ± 1.1% vs. 84.3% ± 1.1%, <0.001) than HCV- women, independent of HIV infection and viral load; there was little difference in PAI-1 or log10 D-dimer. After adjustment for confounders, these inferences remained. HIV infection was independently associated with higher Factor VIII% and log10 D-dimer and lower TPS.ConclusionsHCV was independently associated with higher Factor VIII% and lower TPS consistent with hypercoagulability. Higher Factor VIII% and D-dimer and lower TPS were also strongly associated with HIV infection and levels of HIV viremia, independent of HCV infection. Further investigation is needed to determine if there is increased thrombotic risk from HCV. Studies examining hemostasis markers in HIV infection must also assess the contribution of HCV infection. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt8w81s6kz; https://escholarship.org/uc/item/8w81s6kzTest |
| الإتاحة: |
https://escholarship.org/uc/item/8w81s6kzTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.46CC6866 |
| قاعدة البيانات: |
BASE |
