التفاصيل البيبلوغرافية
| العنوان: |
Immunochip Analysis Identification of 6 Additional Susceptibility Loci for Crohn's Disease in Koreans |
| المؤلفون: |
Yang, Suk-Kyun, Hong, Myunghee, Choi, Hyunchul, Zhao, Wanting, Jung, Yusun, Haritunians, Talin, Ye, Byong Duk, Kim, Kyung-Jo, Park, Sang Hyoung, Lee, Inchul, Kim, Won Ho, Cheon, Jae Hee, Kim, Young-Ho, Jang, Byung Ik, Kim, Hyun-Soo, Choi, Jai Hyun, Koo, Ja Seol, Lee, Ji Hyun, Jung, Sung-Ae, Shin, Hyoung Doo, Kang, Daehee, Youn, Hee-Shang, Taylor, Kent D, Rotter, Jerome I, Liu, Jianjun, McGovern, Dermot PB, Song, Kyuyoung |
| المصدر: |
Inflammatory Bowel Diseases, vol 21, iss 1 |
| بيانات النشر: |
eScholarship, University of California |
| سنة النشر: |
2015 |
| المجموعة: |
University of California: eScholarship |
| مصطلحات موضوعية: |
Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Inflammatory Bowel Disease, Human Genome, Autoimmune Disease, Crohn's Disease, Genetics, Clinical Research, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Asian People, Biomarkers, Case-Control Studies, Cohort Studies, Crohn Disease, Female, Follow-Up Studies, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Humans, Male, Odds Ratio, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide |
| جغرافية الموضوع: |
1 - 7 |
| الوصف: |
BackgroundCrohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population.MethodsUsing the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls.ResultsWe confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans.ConclusionsAlthough the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
unknown |
| العلاقة: |
qt0mj6g4qh; https://escholarship.org/uc/item/0mj6g4qhTest |
| الإتاحة: |
https://escholarship.org/uc/item/0mj6g4qhTest |
| حقوق: |
public |
| رقم الانضمام: |
edsbas.3A8A5A8A |
| قاعدة البيانات: |
BASE |
