المؤلفون: Caroline Robert, Jacob Schachter, Thierry Lesimple, C. Dutriaux, Dirk Schadendorf, Monique Tan, Axel Hauschild, Georgina V. Long, R. Dummer, Eduard Gasal, Mario Santinami, Kohinoor Dasgupta, James Larkin, Mario Mandalà, Andrew M. Haydon, John M. Kirkwood, Vanna Chiarion Sileni, Laurent Mortier, Victoria Atkinson, Marta Nyakas, Ruth Plummer

المساهمون: University of Zurich

مصطلحات موضوعية: Male, Oncology, Skin Neoplasms, medicine.medical_treatment, Medizin, Administration, Oral, 2700 General Medicine, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antineoplastic Combined Chemotherapy Protocols, Oximes, Medicine, 030212 general & internal medicine, Neoplasm Metastasis, Melanoma, Trametinib, Imidazoles, Follow up studies, 10177 Dermatology Clinic, General Medicine, Middle Aged, Female, Adjuvant, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Pyridones, 610 Medicine & health, Pyrimidinones, Disease-Free Survival, 03 medical and health sciences, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, Humans, Stage III melanoma, Protein Kinase Inhibitors, Survival analysis, Aged, Neoplasm Staging, business.industry, Dabrafenib, Survival Analysis, Clinical trial, Mutation, business, Follow-Up Studies

وصف الملف: 848_Dummer_R._et_al._Five-Year_Analysis_of_Adjuvant_Dabrafenib_plus_Trametinib_in_Stage_III_Melanoma_NEJM_2020.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d710d2b0f671e5dafc838391b9965d4aTest
https://www.zora.uzh.ch/id/eprint/190018Test

المؤلفون: Eduard Gasal, Paul Nathan, Antoni Ribas, Neha Pakhle, Victoria Atkinson, Céleste Lebbé, Dirk Schadendorf, Mario Mandalà, Daniel Gusenleitner, Paolo A. Ascierto, Aisha Masood, Erika Richtig, Catarina D. Campbell, Reinhard Dummer, Ana Arance, Keith T. Flaherty, Hussein Abdul-Hassan Tawbi, Naoya Yamazaki, Georgina V. Long, Caroline Robert, Jan C. Brase

المساهمون: University of Zurich, Dummer, Reinhard

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Skin Neoplasms, Medizin, Cohort Studies, 0302 clinical medicine, Antineoplastic Agents, Immunological, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, Neoplasm Metastasis, Immune Checkpoint Inhibitors, Melanoma, Trametinib, MEK inhibitor, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, MAP Kinase Kinase Kinases, Treatment Outcome, 030220 oncology & carcinogenesis, Disease Progression, Biomarker (medicine), Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Pyridones, Mutation, Missense, 610 Medicine & health, Genetics and Molecular Biology, Pyrimidinones, Antibodies, Monoclonal, Humanized, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Young Adult, 1300 General Biochemistry, Genetics and Molecular Biology, Internal medicine, medicine, Biomarkers, Tumor, Humans, Protein Kinase Inhibitors, Aged, business.industry, Dabrafenib, medicine.disease, Clinical trial, Regimen, 030104 developmental biology, General Biochemistry, business

وصف الملف: 870_Dummer_R._et_al._Combined_PD-1,_BRAF_and_MEK_inhibition_in_advanced_BRAF-mutant_melanoma_Nature_Medicine_2020.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b17ee96d80a3281cdd7448c58c9110fTest
https://www.ncbi.nlm.nih.gov/pubmed/33020648Test

المؤلفون: Vanna Chiarion-Sileni, M. Mandal, A. Hauschild, Bijoyesh Mookerjee, R. Ji, Jeffrey J. Legos, John M. Kirkwood, Victoria Atkinson, Jacob Schachter, James Larkin, Richard F. Kefford, Ping Zhang, Caroline Robert, Caroline Dutriaux, M. Santinami, Andrew Haydon, Dirk Schadendorf, Georgina V. Long, Thierry Lesimple, Reinhard Dummer, Laurent Mortier, Marta Nyakas, Ruth Plummer

المساهمون: University of Zurich, Long, Georgina V

المصدر: New England Journal of Medicine. 377:1813-1823

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Skin Neoplasms, Medizin, 2700 General Medicine, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, Melanoma, Aged, 80 and over, Trametinib, MEK inhibitor, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Combination therapy, Pyridones, 610 Medicine & health, Pyrimidinones, Young Adult, 03 medical and health sciences, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, medicine, Humans, Survival analysis, Aged, Neoplasm Staging, business.industry, Dabrafenib, medicine.disease, Survival Analysis, Surgery, Clinical trial, 030104 developmental biology, Mutation, Neoplasm Recurrence, Local, business

وصف الملف: 720_Long_GV._et_al._Adjuvant_Dabrafenib_plus_Trametinib_in_Stage_III_NEJM_2017.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20521edecf000680510735bacb9ee32Test
https://doi.org/10.1056/nejmoa1708539Test

المؤلفون: Pascal Wolter, Dirk Schadendorf, Daniil Stroiakovski, Michael Lichinitser, Jeff Legos, Paul Nathan, Peng Sun, Kamil Drucis, Keith T. Flaherty, Boguslawa Karaszewska, Antoni Ribas, Florent Grange, Anne-Marie Martin, Shonda M Little, Reinhard Dummer, Ivana Krajsová, Laurent Mortier, Vanna Chiarion-Sileni, Wendy A. Crist, Paul Lorigan, Stephen D. Rubin, Andrzej Mackiewicz, Piotr Rutkowski, Jacob Schachter, Caroline Robert, Georgina V. Long, Axel Hauschild

المساهمون: University of Zurich, Robert, Caroline

مصطلحات موضوعية: Oncology, Male, Keratoacanthoma, Indoles, Skin Neoplasms, Medizin, Kaplan-Meier Estimate, 2700 General Medicine, chemistry.chemical_compound, Antineoplastic Combined Chemotherapy Protocols, Oximes, Vemurafenib, Melanoma, Trametinib, Aged, 80 and over, education.field_of_study, Sulfonamides, Hazard ratio, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, Intention to Treat Analysis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Pyridones, Population, 610 Medicine & health, Pyrimidinones, Young Adult, Internal medicine, medicine, Humans, education, neoplasms, Protein Kinase Inhibitors, Aged, Cobimetinib, Mitogen-Activated Protein Kinase Kinases, business.industry, Dabrafenib, medicine.disease, Survival Analysis, Surgery, chemistry, Mutation, business

وصف الملف: Robert C et al. - N Engl J Med 2014.pdf - application/pdf; Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb174f02e29f4375b8bd8c23ddb74764Test
https://doi.org/10.5167/uzh-107163Test

المؤلفون: Daniil Stroyakovskiy, Peter Mohr, Virginia Ferraresi, Michael Millward, Paul Nathan, Claus Garbe, Filippo de Braud, Caroline Robert, Jhangir G. Irani, Igor Bondarenko, Vanna Chiarion-Sileni, Jochen Utikal, Nadezhda Kovalenko, Douglas J Demarini, Bijoyesh Mookerjee, James Larkin, Ana Arance, Suzanne Swann, Mario Mandalà, Axel Hauschild, Jeffrey J. Legos, John B. A. G. Haanen, Jean-Jacques Grob, Keith T. Flaherty, Antoni Ribas, Johan Hansson, Dirk Schadendorf, Georgina V. Long, Thomas Jouary, Helen Gogas, Fan Jin, Volodymr Probachai, Céleste Lebbé, Evgeny Levchenko

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, medicine.medical_specialty, Pyridones, Medizin, Phases of clinical research, Pyrimidinones, Placebo, Disease-Free Survival, Young Adult, chemistry.chemical_compound, Double-Blind Method, Internal medicine, Oximes, medicine, Clinical endpoint, Humans, Melanoma, Aged, Aged, 80 and over, Trametinib, Cobimetinib, business.industry, Hazard ratio, Imidazoles, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, Treatment Outcome, chemistry, Drug Therapy, Combination, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305a840ef7860ce6dbedc881e5fe7cfTest
http://hdl.handle.net/11391/1480871Test

المؤلفون: Victoria Atkinson, Céleste Lebbé, Jessica C. Hassel, Catalin Mihalcioiu, Cornelia Mauch, Ewa Kalinka-Warzocha, Ian M. Waxman, Ana Arance, Piotr Rutkowski, Kerry J. Savage, Vanna Chiarion-Sileni, Caroline Dutriaux, Micaela Hernberg, Abstr Act, Laurent Mortier, Catriona M. McNeil, Brian Sharkey, Caroline Robert, Dirk Schadendorf, Michele Maio, Christine Horak, Georgina V. Long, Lotta Lundgren-Eriksson, Benjamin Brady, Helen Gogas, Francesco Cognetti, Henrik Schmidt, Paolo A. Ascierto, Julie Charles

المصدر: Robert, C, Long, G V, Brady, B, Dutriaux, C, Maio, M, Mortier, L, Hassel, J C, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Savage, K J, Hernberg, M M, Lebbé, C, Charles, J, Mihalcioiu, C, Chiarion-Sileni, V, Mauch, C, Cognetti, F, Arance, A, Schmidt, H, Schadendorf, D, Gogas, H, Lundgren-Eriksson, L, Horak, C, Sharkey, B, Waxman, I M, Atkinson, V & Ascierto, P A 2015, ' Nivolumab in previously untreated melanoma without BRAF mutation ', The New England Journal of Medicine, vol. 372, no. 4, pp. 320-30 . https://doi.org/10.1056/NEJMoa1412082Test
New England Journal of Medicine; 372(4), pp 320-330 (2015)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Dacarbazine, Programmed Cell Death 1 Receptor, Medizin, Phases of clinical research, Ipilimumab, Antineoplastic Agents, Pembrolizumab, ipilimumab-refractory metastatic melanoma, Gastroenterology, Disease-Free Survival, Young Adult, Double-Blind Method, Nivolumab, melanoma, ipilimumab-refractory metastatic melanoma, Internal medicine, Medicine, Humans, Survival rate, Melanoma, Aged, Aged, 80 and over, business.industry, Hazard ratio, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Surgery, Survival Rate, Nivolumab, Cancer and Oncology, Female, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07253c758028e0b62a420832a391b6ecTest
https://pubmed.ncbi.nlm.nih.gov/25511188Test

المؤلفون: Daniil Stroyakovskiy, Jochen Utikal, Keith T. Flaherty, Daniele Ouellet, Virginia Ferraresi, Michelle Casey, Claus Garbe, Axel Hauschild, V. Chiarion Sileni, Caroline Robert, Helen Gogas, Antoni Ribas, Michael Millward, Nadezhda Kovalenko, Jean-Jacques Grob, Jhangir G. Irani, Paul Nathan, Dirk Schadendorf, John B. A. G. Haanen, V. Probachai, Mario Mandalà, F. de Braud, Johan Hansson, Georgina V. Long, Igor Bondarenko, Kiran Patel, Ngocdiep T. Le, Anne-Marie Martin, James Larkin, Ana Arance, T. Jouary, Peter Mohr, Douglas J. DeMarini, Céleste Lebbé, Evgeny Levchenko

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Fever, Pyridones, Medizin, Kaplan-Meier Estimate, Pyrimidinones, Gastroenterology, Disease-Free Survival, chemistry.chemical_compound, Double-Blind Method, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Carcinoma, medicine, Clinical endpoint, Humans, Melanoma, Aged, Mitogen-Activated Protein Kinase Kinases, Cobimetinib, Trametinib, business.industry, Hazard ratio, Imidazoles, Binimetinib, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, chemistry, Mutation, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266d13e0581ba3c486d28c2d159ca1daTest
http://hdl.handle.net/11391/1480877Test

المؤلفون: Keith T, Flaherty, Caroline, Robert, Peter, Hersey, Paul, Nathan, Claus, Garbe, Mohammed, Milhem, Lev V, Demidov, Jessica C, Hassel, Piotr, Rutkowski, Peter, Mohr, Reinhard, Dummer, Uwe, Trefzer, James M G, Larkin, Jochen, Utikal, Brigitte, Dreno, Marta, Nyakas, Mark R, Middleton, Jürgen C, Becker, Michelle, Casey, Laurie J, Sherman, Frank S, Wu, Daniele, Ouellet, Anne-Marie, Martin, Kiran, Patel, Dirk, Schadendorf, Mary, Richardson

المصدر: The New England journal of medicine. 367(2)

مصطلحات موضوعية: Oncology, Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Pyridones, Dacarbazine, MAP Kinase Kinase 2, Medizin, MAP Kinase Kinase 1, Antineoplastic Agents, Kaplan-Meier Estimate, Pyrimidinones, Disease-Free Survival, chemistry.chemical_compound, Young Adult, Internal medicine, medicine, Humans, Vemurafenib, Melanoma, Protein Kinase Inhibitors, Aged, Trametinib, Cobimetinib, Aged, 80 and over, business.industry, MEK inhibitor, Hazard ratio, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, Intention to Treat Analysis, chemistry, Mutation, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778f247f586f7abe700c37ec7f75715aTest
http://ora.ox.ac.uk/objects/uuid:17a4cd0c-72ea-46f7-ab36-457c375b3557Test

المؤلفون: Sabine Druillennec, Alain Spatz, Vladimir Lazar, Philippe Dessen, Joost van den Oord, Caroline Robert, Brigitte Bressac-de Paillerets, Caroline Kannengiesser, Stefan Michiels, Alain Sarasin, Fabienne Lesueur, V. Winnepenninckx, Alain Eychène

المصدر: Molecular oncology. 1(4)

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, Skin Neoplasms, Adolescent, Ultraviolet Rays, DNA Mutational Analysis, Mutation, Missense, Biology, medicine.disease_cause, Young Adult, Cell Movement, Gene expression, Genetics, medicine, Humans, Child, neoplasms, Melanoma, Aged, Regulation of gene expression, Aged, 80 and over, Mutation, Melanosomes, Gene Expression Profiling, Immunity, Infant, General Medicine, Middle Aged, medicine.disease, Microphthalmia-associated transcription factor, Molecular biology, digestive system diseases, Gene expression profiling, Gene Expression Regulation, Neoplastic, Genes, ras, Oncology, Child, Preschool, Cutaneous melanoma, Papers, Cancer research, Molecular Medicine, Female, DNA Probes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa656a369a59863ffb03c4699bc7235Test
https://pubmed.ncbi.nlm.nih.gov/19383316Test