Anti-MOG encephalitis mimicking small vessel CNS vasculitis
| العنوان: | Anti-MOG encephalitis mimicking small vessel CNS vasculitis |
|---|---|
| المؤلفون: | Mariona Suñol, Albert Saiz, Jordi Anton, Verónica González-Álvarez, MacLean Nasrallah, Thaís Armangue, Eric Lancaster, Kristina R. Patterson, Estibaliz Iglesias |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Neurology® Neuroimmunology & Neuroinflammation |
| بيانات النشر: | American Academy of Neurology, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Pathology, Biopsy, Símptomes, Serology, 0302 clinical medicine, Medicine, Fibrinoid necrosis, Neuropathology, medicine.diagnostic_test, Brain, Magnetic Resonance Imaging, 3. Good health, Myelin-Associated Glycoprotein, Editorial, Neurology, Child, Preschool, Encephalitis, Female, Vasculitis, Biòpsia, medicine.drug, Adult, medicine.medical_specialty, Cyclophosphamide, Lymphocytic pleocytosis, Immunoglobulins, Article, Diagnosis, Differential, 03 medical and health sciences, Humans, Vasculitis, Central Nervous System, Retrospective Studies, business.industry, Brain biopsy, Encefalitis, medicine.disease, 030104 developmental biology, nervous system, Symptoms, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), business, Immunoglobulines, 030217 neurology & neurosurgery, Demyelinating Diseases |
| الوصف: | ObjectiveTo report 2 patients with anti–myelin oligodendrocyte glycoprotein (MOG)-associated encephalitis who were initially misdiagnosed with small vessel primary CNS vasculitis.MethodsReview of symptoms, MRI and neuropathologic features, and response to treatment. MOG antibodies were determined in serum and CSF using a cell-based assay.ResultsSymptoms included fever, headache, and progressive mental status changes and focal neurologic deficits. CSF studies revealed lymphocytic pleocytosis, and both patients had abnormal brain MRIs. Brain biopsy samples showed prominent lymphocytic infiltration of the wall of small vessels; these findings initially suggested small vessel CNS vasculitis, and both patients were treated accordingly. Although 1 patient had a relapsing-remitting course not responsive to cyclophosphamide, the other one (also treated with cyclophosphamide) did not relapse. Retrospective assessment of serum and CSF demonstrated MOG antibodies in both cases, and review of biopsy specimens showed absence of fibrinoid necrosis (a pathologic requirement for small vessel CNS vasculitis).ConclusionsAnti–MOG-associated encephalitis can be mistaken for small vessel CNS vasculitis. This is important because the diagnosis of anti–MOG-associated encephalitis does not require brain biopsy and can be established with a serologic test. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b66d2c9ee1101c6cc46d2e063199fa2Test http://hdl.handle.net/2445/164792Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b66d2c9ee1101c6cc46d2e063199fa2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |