نتائج البحث

1

The Lived Experience of Canadian University Students with Type 1 Diabetes Mellitus

المؤلفون: Jacqui Gingras, Enza Gucciardi, Stephanie Hill

مصطلحات موضوعية: Gerontology, Adult, Male, Canada, Health Knowledge, Attitudes, Practice, diabète de type 1, Universities, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Population, education, expérience vécue, Young Adult, Quality of life (healthcare), Endocrinology, Diabetes mellitus, Health care, Internal Medicine, Medicine, Humans, university students, Students, Analysis method, education.field_of_study, Medical education, Type 1 diabetes, business.industry, Lived experience, étudiants, General Medicine, Focus Groups, medicine.disease, Focus group, Diet, Self Care, diabète sucré de type 1, Diabetes Mellitus, Type 1, lived experience, Female, business, type 1 diabetes mellitus

الوصف: Objective: The purpose of this study was to examine the lived experiences of university students with type 1 diabetes mellitus. Methods: University students participated in a 2-part focus group. Transcripts were analyzed thematically using an open-coding approach. Data analysis was guided by a framework analysis method and emergent themes were triangulated between study authors for validity. Results: Three major themes identified in this study were food issues within the university environment, lack of diabetes awareness on campus and internal struggles related to the participants' relationships with their diabetes. Conclusions: Results illustrate some of the unique challenges that interfere with diabetes self-management, academic performance and quality of life among this sample of university students. Findings can provide insight for diabetes educators and other healthcare practitioners regarding the issues that may interfere with optimal diabetes self-care in this population. Findings also can be used to inform university administrators how to make the university environment more diabetes friendly for its students.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ab859c0a32ab454b7f5afed3d71bd5Test
https://doi.org/10.32920/14636700.v1Test

2

Advanced Diabetes Technology Remains Underutilized in Underserved Populations: Early Hybrid Closed-Loop System Experience at an Academic Safety Net Hospital

المؤلفون: Zhihui Ju, Elizabeth Brouillard, Devin Steenkamp, Amanda Piarulli, Shannon Marschall, Lauren Bielick

المصدر: Diabetes Technology & Therapeutics. 24:143-147

الوصف: We retrospectively evaluated outcomes of the Minimed Medtronic 670G system in an academic urban safety-net population of adults with type 1 diabetes, between September 2016 and January 2020. Among 32 patients prescribed the 670G, the majority were female (69%), white (69%), achieved advanced degrees (56%), were commercially insured (94%), and were experienced pump users (84%). Patients who initiated auto-mode demonstrated significant improvement in A1c after 1 year. However, 31% of patients never initiated auto-mode. Black and Hispanic patients comprised 50% of this group, despite similar insurance coverage, diabetes duration, educational level, and prior pump use. Hence, traditional barriers to technology use do not explain these racial/ethnic disparities. Of 22 patients who initiated auto-mode, 5 discontinued within 1 year. The most common reason for discontinuation was frustration with pump-sensor interactions. Future studies identifying barriers to and strategies for increasing use of advanced insulin delivery systems in underserved populations are needed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855fc80d3342a43cbae0f8c0587f1152Test
https://doi.org/10.1089/dia.2021.0334Test

3

Epidemiological characteristics of diabetic kidney disease in Taiwan

المؤلفون: Kun-Der Lin, Jun-Sing Wang, Chih-Cheng Hsu, Yueh-Han Hsu, Fu-Shun Yen, Shyi-Jang Shin

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2112-2123 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Taiwan, Review Article, Type 2 diabetes, Prognostic factors, Diseases of the endocrine glands. Clinical endocrinology, End stage renal disease, Young Adult, Renal Dialysis, Internal medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Diabetic kidney disease, Family history, education, Dialysis, Aged, Type 1 diabetes, education.field_of_study, business.industry, Incidence, General Medicine, Middle Aged, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Risk factors, Kidney Failure, Chronic, Female, business, Dyslipidemia

الوصف: Diabetic kidney disease (DKD) is a critical microvascular complication of diabetes. With the continuous increase in the prevalence of diabetes since 2000, the prevalence of DKD has also been increasing in past years. The prevalence of DKD among individuals with type 2 diabetes in Taiwan increased from 13.32% in 2000 to 17.92% in 2014. The cumulative incidence of DKD among individuals with type 1 diabetes in Taiwan was higher than 30% during 1999–2012. DKD is the leading cause of end‐stage renal disease (ESRD), with a prevalence of approximately 45% in a population on chronic dialysis in Taiwan. Among individuals with type 2 diabetes, the prevalence of ESRD in the receipt of dialysis also increased from 1.32% in 2005 to 1.47% in 2014. Risk factors for DKD development are age, race, family history, hyperglycemia, hypertension, dyslipidemia, dietary patterns, and lifestyles. Prognostic factors that aggravate DKD progression include age, family history, sex, glycemic control, blood pressure (BP), microvascular complications, and atherosclerosis. This review summarizes updated information on the onset and progression of DKD, particularly in the Taiwanese population. Translating these epidemiological features is essential to optimizing the kidney care and improving the prognosis of DKD in Asian populations.
This review summarizes updated information on the onset and progression of DKD, particularly in Taiwan. Translating these epidemiological features is essential to optimizing kidney care and improving the prognosis of DKD in Asian populations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1157b0db864fd756da0757f4168a35eTest
https://doi.org/10.1111/jdi.13668Test

4

Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan

المؤلفون: Sadanori Okada, Takehiro Sugiyama, Tomoaki Imamura, Tomoya Myojin, Hitoshi Ishii, Tsuneyuki Higashino, Tatsuya Noda, Shinichiro Kubo, Hiroki Nakajima, Yuichi Nishioka

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1797-1804 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Rate ratio, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Japan, Diabetes mellitus type 1, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, medicine, Humans, Poisson regression, Child, education, Aged, Retrospective Studies, Type 1 diabetes, education.field_of_study, business.industry, Incidence, Infant, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, medicine.disease, RC648-665, Confidence interval, Influenza, Diabetes Mellitus, Type 1, 030104 developmental biology, Child, Preschool, Cohort, symbols, Female, Original Article, business

الوصف: Aim This study aimed to determine whether there is an association between influenza and new‐onset type 1 diabetes. Materials and methods This population‐based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check‐ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new‐onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding. Results The data of 10,400 patients with new‐onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3‐fold (95% confidence interval: 1.15–1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times. Conclusions In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes increased after being diagnosed with influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2addc8fa0427d6b6ec3052b564d1117Test
https://doaj.org/article/6e005e4f525042c88b95614b668a0c6dTest

5

Prevalence and Risk Evaluation of Diabetic Complications of the Foot Among Adults With Type 1 and Type 2 Diabetes in a Large Canadian Population (PEDAL Study)

المؤلفون: Lisa Chu, Ronnie Aronson, Ruth E. Brown, Nicole Joseph

المصدر: Canadian Journal of Diabetes. 45:588-593

الوصف: Objectives The lower limb complications of diabetes contribute significantly to patient morbidity and health-care costs in Canada. Despite practice guidelines, awareness of and screening for modifiable early pathologies has been inconsistent. Our study objective was to determine the prevalence and types of early foot pathology in a large, Canadian, community care–based diabetes population. Methods This study was a retrospective, observational analysis of the LMC Diabetes & Endocrinology foot care program launched in 2017. We examined foot pathologies associated with vascular, nerve, nail and dermatologic complications, as well as foot deformities. Individuals ≥18 years of age with diabetes, assessed by an LMC chiropodist in Ontario between February 2018 and April 2019, were included in the analysis. Results Of the 5,084 individuals assessed, 470 with type 1 diabetes and 3,903 with type 2 diabetes met the study criteria. Mean age, body mass index and diabetes duration were 61.5 years, 31.3 kg/m2 and 13.9 years, respectively. Reduced pedal pulses, sensory neuropathy and onychomycosis were reported in 8.9%, 16.7% and 14.5% of those in the type 1 diabetes group, and in 19.4%, 26.6% and 28.7% of those in the type 2 group, respectively. Hyperkeratosis was present in 51% and foot deformities were present in 44.5% among both groups. Foot ulcer prevalence was 1.7%, and pedal pulses, sensory neuropathy, hyperkeratosis and onychauxis, adjusted for age, sex, body mass index and diabetes duration, were each significantly associated with ulceration. Conclusions In a large foot screening program of community-based adults with diabetes, modifiable early foot pathologies were prevalent and provided further evidence of the value of consistent screening to alleviate the morbidity and economic burden of lower limb complications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3980c195f7ae5c3ad64e3979fece673eTest
https://doi.org/10.1016/j.jcjd.2020.11.011Test

6

Risk of substance use disorders among adolescents and emerging adults with type 1 diabetes: A population‐based cohort study

المؤلفون: Seema Kumar, Ana L. Creo, Amy L. Weaver, Aida N. Lteif, Swetha Sriram, Lisa E. Vaughan

المصدر: Pediatric Diabetes. 22:1143-1149

الوصف: Adolescents and emerging adults with chronic health conditions such as type 1 diabetes mellitus (T1D) are more likely to engage in high-risk behaviors. Previous studies regarding substance use in adolescents and emerging adults with T1D are mostly derived from cross-sectional studies utilizing self-administered questionnaires and are limited by lack of population-based comparison groups. In addition, despite the rising popularity of vaping, little is known about the incidence of vaping in adolescents and emerging adults with T1D. We explored the incidence and prospective risk of substance use disorders and vaping in adolescents and emerging adults with T1D compared to age and gender matched non-diabetic referents residing in Olmsted County, Rochester, MN. Risk of incident substance use disorder washigher in those with T1D compared to matched referents with alcohol, marijuana, and smoked tobacco being most common substances. When stratified by gender, these differences remained significant in males, but not females. While further work is needed to delineate the causative relationships between T1D, mental health, and substance abuse; our findings confirm the critical need for substance use screening and mental health support for adolescents and emerging adults with T1D. This article is protected by copyright. All rights reserved.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de75cb9a3031b4c6cc5cba65c15806dcTest
https://doi.org/10.1111/pedi.13266Test

7

Overall and Cause-Specific Mortality in Patients With Type 1 Diabetes Mellitus: A Population-Based Cohort Study in Taiwan From 1998 Through 2014

المؤلفون: Ya Hui Chang, Chung Yi Li, Santi Martini, Chin-Li Lu, Ming-Fong Chang

المصدر: Journal of Epidemiology
Journal of Epidemiology, Vol 31, Iss 9, Pp 503-510 (2021)

مصطلحات موضوعية: Adult, Male, Medicine (General), medicine.medical_specialty, standardized mortality ratio, Adolescent, type 1 diabetes, Epidemiology, Population, Taiwan, 030209 endocrinology & metabolism, Cohort Studies, Young Adult, 03 medical and health sciences, R5-920, 0302 clinical medicine, Cause of Death, Internal medicine, Diabetes mellitus, medicine, Humans, Clinical Epidemiology, 030212 general & internal medicine, Child, education, Cause of death, Type 1 diabetes, education.field_of_study, business.industry, Mortality rate, Infant, Newborn, Infant, General Medicine, Middle Aged, medicine.disease, mortality, Diabetes Mellitus, Type 1, Standardized mortality ratio, underlying cause of death, Child, Preschool, Cohort, Original Article, Female, business, Cohort study

الوصف: Background: To investigate all-cause and cause-specific mortality in Taiwanese patients with type 1 diabetes. Methods: A cohort of 17,203 patients with type 1 diabetes were identified from Taiwan’s National Health Insurance claims in the period of 1998–2014. Person-years were accumulated for each individual from date of type 1 diabetes registration to date of death or the last day of 2014. Age, sex, and calendar year standardized mortality ratios (SMRs) were calculated with reference to the general population. Results: In up to 17 years of follow-up, 4,916 patients died from 182,523 person-years. Diabetes (30.15%), cancer (20.48%), circulatory diseases (13.14%), and renal diseases (11.45%) were the leading underlying causes of death. Mortality rate (26.93 per 1,000 person-years) from type 1 diabetes in Taiwan was high, the cause of death with the highest mortality rate was diabetes (8.12 per 1,000 person-years), followed by cancer (5.52 per 1,000 person-years), and circulatory diseases (3.54 per 1,000 person-years). The all-cause SMR was significantly elevated at 4.16 (95% confidence interval, 4.04–4.28), with a greater all-cause SMR noted in females than in males (4.62 vs 3.79). The cause-specific SMR was highly elevated for diabetes (SMR, 16.45), followed by renal disease (SMR, 14.48), chronic hepatitis and liver cirrhosis (SMR, 4.91) and infection (SMR, 4.59). All-cause SMRs were also significantly increased for all ages, with the greatest figure noted for 15–24 years (SMR, 8.46). Conclusions: Type 1 diabetes in both genders and all ages was associated with significantly elevated SMRs for all-cause and mostly for diabetes per se and renal disease.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6e9ab22ff81a7a316d1593bcfc6bbdTest
https://doi.org/10.2188/jea.je20200026Test

8

Comparing real-time and intermittently scanned continuous glucose monitoring in adults with type 1 diabetes (ALERTT1): a 6-month, prospective, multicentre, randomised controlled trial

المؤلفون: Steffen Fieuws, Bart Keymeulen, Margaretha M Visser, Christophe De Block, Chantal Mathieu, Eveline Dirinck, Liesbeth Van Huffel, Nele Myngheer, Frank Nobels, Chris Vercammen, Gerd Vanhaverbeke, Pieter Gillard, Robert Hilbrands, Sara Charleer, Toon Maes

المساهمون: Pathology/molecular and cellular medicine, Diabetes Clinic, Diabetes Pathology & Therapy

المصدر: The lancet : international edition

مصطلحات موضوعية: Adult, Blood Glucose, Male, Pediatrics, medicine.medical_specialty, type 1 diabetes, Endocrinology, Diabetes and Metabolism, Population, 030204 cardiovascular system & hematology, Hypoglycemia, Minimisation (clinical trials), law.invention, 03 medical and health sciences, Insulin Infusion Systems, 0302 clinical medicine, Belgium, Randomized controlled trial, Quality of life, law, Diabetes mellitus, medicine, Clinical endpoint, Humans, Hypoglycemic Agents, Insulin, Prospective Studies, 030212 general & internal medicine, education, Glycated Hemoglobin, Type 1 diabetes, education.field_of_study, business.industry, Blood Glucose Self-Monitoring, ADULTS, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Quality of Life, Female, Human medicine, business

الوصف: Background People with type 1 diabetes can continuously monitor their glucose levels on demand (intermittently scanned continuous glucose monitoring [isCGM]), or in real time (real-time continuous glucose monitoring [rtCGM]). However, it is unclear whether switching from isCGM to rtCGM with alert functionality offers additional benefits. Therefore, we did a trial comparing rtCGM and isCGM in adults with type 1 diabetes (ALERTT1). Methods We did a prospective, double-arm, parallel-group, multicentre, randomised controlled trial in six hospitals in Belgium. Adults with type 1 diabetes who previously used isCGM were randomly assigned (1:1) to rtCGM (intervention) or isCGM (control). Randomisation was done centrally using minimisation dependent on study centre, age, gender, glycated haemoglobin (HbA(1c)), time in range (sensor glucose 3.9-10.0 mmol/L), insulin administration method, and hypoglycaemia awareness. Participants, investigators, and study teams were not masked to group allocation. Primary endpoint was mean between-group difference in time in range after 6 months assessed in the intention-to-treat sample. This trial is registered with ClinicalTrials.gov, NCT03772600. Findings Between Jan 29 and July 30, 2019, 269 participants were recruited, of whom 254 were randomly assigned to rtCGM (n=127) or isCGM (n=127); 124 and 122 participants completed the study, respectively. After 6 months, time in range was higher with rtCGM than with isCGM (59.6% vs 51.9%; mean difference 6.85 percentage points [95% CI 4.36-9.34]; p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084f253f6137d52d2bbbd2c95df26694Test
https://doi.org/10.1016/s0140-6736Test(21)00789-3

9

Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes

المؤلفون: Carmella Evans-Molina, Clive Wasserfall, Megan T Legge, Eleni Beli, Craig A. Beam, Ryan Silk, Kieran M. Mcgrail, Linda A. DiMeglio, Mark A. Atkinson, Stephanie Woerner, Maria B. Grant

المصدر: Diabetologia
Beam, C A, Beli, E, Wasserfall, C H, Woerner, S E, Legge, M T, Evans-Molina, C, McGrail, K M, Silk, R, Grant, M B, Atkinson, M A & DiMeglio, L A 2021, ' Peripheral immune circadian variation, synchronisation and possible dysrhythmia in established type 1 diabetes ', Diabetologia . https://doi.org/10.1007/s00125-021-05468-6Test

مصطلحات موضوعية: 0301 basic medicine, CD4-Positive T-Lymphocytes, Male, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Circadian clock, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, Mice, 0302 clinical medicine, Cytotoxic T cell, education.field_of_study, B-Lymphocytes, Immune cells, Flow Cytometry, Circadian Rhythm, Cytokine, Type 1 diabetes, Female, Adult, Adolescent, Period (gene), Population, Biology, Chronobiology Disorders, circadian ryhtms, Article, 03 medical and health sciences, Clinical, Young Adult, Immune system, SDG 3 - Good Health and Well-being, Circadian Clocks, Internal Medicine, medicine, Animals, Humans, Circadian rhythms, Circadian rhythm, Lymphocyte Count, education, Interleukin-6, Dendritic Cells, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Diabetes Mellitus, Type 1, Immune System, Immunology, 030217 neurology & neurosurgery

الوصف: Aims/hypothesis The circadian clock influences both diabetes and immunity. Our goal in this study was to characterise more thoroughly the circadian patterns of immune cell populations and cytokines that are particularly relevant to the immune pathology of type 1 diabetes and thus fill in a current gap in our understanding of this disease. Methods Ten individuals with established type 1 diabetes (mean disease duration 11 years, age 18–40 years, six female) participated in a circadian sampling protocol, each providing six blood samples over a 24 h period. Results Daily ranges of population frequencies were sometimes large and possibly clinically significant. Several immune populations, such as dendritic cells, CD4 and CD8 T cells and their effector memory subpopulations, CD4 regulatory T cells, B cells and cytokine IL-6, exhibited statistically significant circadian rhythmicity. In a comparison with historical healthy control individuals, but using shipped samples, we observed that participants with type 1 diabetes had statistically significant phase shifts occurring in the time of peak occurrence of B cells (+4.8 h), CD4 and CD8 T cells (~ +5 h) and their naive and effector memory subsets (~ +3.3 to +4.5 h), and regulatory T cells (+4.1 h). An independent streptozotocin murine experiment confirmed the phase shifting of CD8 T cells and suggests that circadian dysrhythmia in type 1 diabetes might be an effect and not a cause of the disease. Conclusions/interpretation Future efforts investigating this newly described aspect of type 1 diabetes in human participants are warranted. Peripheral immune populations should be measured near the same time of day in order to reduce circadian-related variation. Graphical abstract

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5304384a2a7eb86434e13bd1acc63ddbTest
http://europepmc.org/articles/PMC8245361Test

10

Treatment for T1DM patients by a neuro-fuzzy inverse optimal controller including multi-step prediction

المؤلفون: Edgar N. Sanchez, E. Ruiz-Velázquez, Alma Y. Alanis, Aldo Pardo García, Y. Yuliana Rios, J.A. García-Rodríguez

المصدر: ISA Transactions-Vol. 126
ISA Transactions
Repositorio Institucional UTB
Universidad Tecnológica de Bolívar
instacron:Universidad Tecnológica de Bolívar

مصطلحات موضوعية: Adult, Blood Glucose, Uva/Padova simulator, Adolescent, Neuro-fuzzy, Computer science, Population, Recurrent neural network, Machine learning, computer.software_genre, Fuzzy logic, Chart, Control theory, medicine, Diabetes Mellitus, Humans, Hypoglycemic Agents, Insulin, Computer Simulation, Electrical and Electronic Engineering, Child, education, Instrumentation, Type 1 diabetes, education.field_of_study, Neural multi-step predictor, LEMB, business.industry, Applied Mathematics, Type 1 Diabetes Mellitus, medicine.disease, Computer Science Applications, Fuzzy inference, Diabetes Mellitus, Type 1, Basal (medicine), Control and Systems Engineering, Artificial intelligence, business, computer, Algorithms

الوصف: Diabetes Mellitus is a serious metabolic condition for global health associations. Recently, the number of adults, adolescents and children who have developed Type 1 Diabetes Mellitus (T1DM) has increased as well as the mortality statistics related to this disease. For this reason, the scientific community has directed research in developing technologies to reduce T1DM complications. This contribution is related to a feedback control strategy for blood glucose management in population samples of ten virtual adult subjects, adolescents and children. This scheme focuses on the development of an inverse optimal control (IOC) proposal which is integrated by neural identification, a multi-step prediction (MSP) strategy, and Takagi-Sugeno (T-S) fuzzy inference to shape the convenient insulin infusion in the treatment of T1DM patients. The MSP makes it possible to estimate the glucose dynamics 15 min in advance; therefore, this estimation allows the Neuro-Fuzzy-IOC (NF-IOC) controller to react in advance to prevent hypoglycemic and hyperglycemic events. The T-S fuzzy membership functions are defined in such a way that the respective inferences change basal infusion rates for each patient's condition. The results achieved for scenarios simulated in Uva/Padova virtual software illustrate that this proposal is suitable to maintain blood glucose levels within normoglycemic values (70-115 mg/dL); furthermore, this level remains less than 250 mg/dL during the postprandial event. A comparison between a simple neural IOC (NIOC) and the proposed NF-IOC is carried out using the analysis for control variability named CVGA chart included in the Uva/Padova software. This analysis highlights the improvement of the NF-IOC treatment, proposed in this article, on the NIOC approach because each subject is located inside safe zones for the entire duration of the simulation.

وصف الملف: 10 páginas; Pdf; application/pdf; 10 Páginas

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ade8a21909940c7816914c3a72f8f6Test
https://hdl.handle.net/20.500.12585/12172Test

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