المؤلفون: Ralf, Gutzmer, Daniil, Stroyakovskiy, Helen, Gogas, Caroline, Robert, Karl, Lewis, Svetlana, Protsenko, Rodrigo P, Pereira, Thomas, Eigentler, Piotr, Rutkowski, Lev, Demidov, Georgy Moiseevich, Manikhas, Yibing, Yan, Kuan-Chieh, Huang, Anne, Uyei, Virginia, McNally, Grant A, McArthur, Paolo A, Ascierto

المصدر: Lancet (London, England). 395(10240)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate, Middle Aged, Antibodies, Monoclonal, Humanized, Drug Administration Schedule, Progression-Free Survival, Double-Blind Method, Piperidines, Vemurafenib, Antineoplastic Combined Chemotherapy Protocols, Mutation, Azetidines, Humans, Female, Neoplasm Metastasis, Melanoma, Aged, Neoplasm Staging

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::ae0fc6f1503f4e8640866ea2c3ddd337Test
https://pubmed.ncbi.nlm.nih.gov/32798490Test

المؤلفون: Caroline Robert, Jacob Schachter, Thierry Lesimple, C. Dutriaux, Dirk Schadendorf, Monique Tan, Axel Hauschild, Georgina V. Long, R. Dummer, Eduard Gasal, Mario Santinami, Kohinoor Dasgupta, James Larkin, Mario Mandalà, Andrew M. Haydon, John M. Kirkwood, Vanna Chiarion Sileni, Laurent Mortier, Victoria Atkinson, Marta Nyakas, Ruth Plummer

المساهمون: University of Zurich

مصطلحات موضوعية: Male, Oncology, Skin Neoplasms, medicine.medical_treatment, Medizin, Administration, Oral, 2700 General Medicine, 030204 cardiovascular system & hematology, law.invention, 0302 clinical medicine, Randomized controlled trial, law, Antineoplastic Combined Chemotherapy Protocols, Oximes, Medicine, 030212 general & internal medicine, Neoplasm Metastasis, Melanoma, Trametinib, Imidazoles, Follow up studies, 10177 Dermatology Clinic, General Medicine, Middle Aged, Female, Adjuvant, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Pyridones, 610 Medicine & health, Pyrimidinones, Disease-Free Survival, 03 medical and health sciences, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, Humans, Stage III melanoma, Protein Kinase Inhibitors, Survival analysis, Aged, Neoplasm Staging, business.industry, Dabrafenib, Survival Analysis, Clinical trial, Mutation, business, Follow-Up Studies

وصف الملف: 848_Dummer_R._et_al._Five-Year_Analysis_of_Adjuvant_Dabrafenib_plus_Trametinib_in_Stage_III_Melanoma_NEJM_2020.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d710d2b0f671e5dafc838391b9965d4aTest
https://www.zora.uzh.ch/id/eprint/190018Test

المؤلفون: Reinhard, Dummer, Jan C, Brase, James, Garrett, Catarina D, Campbell, Eduard, Gasal, Matthew, Squires, Daniel, Gusenleitner, Mario, Santinami, Victoria, Atkinson, Mario, Mandalà, Vanna, Chiarion-Sileni, Keith, Flaherty, James, Larkin, Caroline, Robert, Richard, Kefford, John M, Kirkwood, Axel, Hauschild, Dirk, Schadendorf, Georgina V, Long

المصدر: The Lancet. Oncology. 21(3)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Adolescent, Pyridones, Pyrimidinones, Young Adult, Double-Blind Method, Antineoplastic Combined Chemotherapy Protocols, Oximes, Humans, Neoplasm Metastasis, Melanoma, Aged, Aged, 80 and over, Salvage Therapy, Imidazoles, Middle Aged, Prognosis, Survival Rate, Drug Resistance, Neoplasm, Mutation, Female, Neoplasm Recurrence, Local, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::82f686582204c03888e4020dc478c975Test
https://pubmed.ncbi.nlm.nih.gov/32007137Test

المؤلفون: Vanna Chiarion-Sileni, M. Mandal, A. Hauschild, Bijoyesh Mookerjee, R. Ji, Jeffrey J. Legos, John M. Kirkwood, Victoria Atkinson, Jacob Schachter, James Larkin, Richard F. Kefford, Ping Zhang, Caroline Robert, Caroline Dutriaux, M. Santinami, Andrew Haydon, Dirk Schadendorf, Georgina V. Long, Thierry Lesimple, Reinhard Dummer, Laurent Mortier, Marta Nyakas, Ruth Plummer

المساهمون: University of Zurich, Long, Georgina V

المصدر: New England Journal of Medicine. 377:1813-1823

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Skin Neoplasms, Medizin, 2700 General Medicine, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, Melanoma, Aged, 80 and over, Trametinib, MEK inhibitor, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Combination therapy, Pyridones, 610 Medicine & health, Pyrimidinones, Young Adult, 03 medical and health sciences, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, medicine, Humans, Survival analysis, Aged, Neoplasm Staging, business.industry, Dabrafenib, medicine.disease, Survival Analysis, Surgery, Clinical trial, 030104 developmental biology, Mutation, Neoplasm Recurrence, Local, business

وصف الملف: 720_Long_GV._et_al._Adjuvant_Dabrafenib_plus_Trametinib_in_Stage_III_NEJM_2017.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20521edecf000680510735bacb9ee32Test
https://doi.org/10.1056/nejmoa1708539Test

المؤلفون: John M. Kirkwood, James Larkin, Mario Mandalà, Richard F. Kefford, Tomas Haas, Vanna Chiarion-Sileni, Caroline Robert, Kohinoor Dasgupta, Axel Hauschild, Mario Santinami, Mark Shilkrut, Caroline Dutriaux, Eduard Gasal, Dirk Schadendorf, Georgina V. Long, Jacob Schachter, Andrew Haydon, Laurent Mortier, Ruth Plummer, Victoria Atkinson, Marta Nyakas, Thierry Lesimple, Reinhard Dummer

المساهمون: University of Zurich, Long, Georgina V

المصدر: Journal of Clinical Oncology
J Clin Oncol

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Cancer Research, Internationality, Skin Neoplasms, Time Factors, Medizin, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, 1306 Cancer Research, Stage (cooking), Melanoma, Trametinib, Hazard ratio, Age Factors, Imidazoles, 10177 Dermatology Clinic, Middle Aged, Treatment Outcome, 030220 oncology & carcinogenesis, Female, 2730 Oncology, Rapid Communication, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Pyridones, 610 Medicine & health, Pyrimidinones, Placebo, Disease-Free Survival, Drug Administration Schedule, 03 medical and health sciences, Sex Factors, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, Correspondence, medicine, Humans, Dose-Response Relationship, Drug, business.industry, Cancer, Dabrafenib, medicine.disease, Clinical trial, 030104 developmental biology, business, Follow-Up Studies

وصف الملف: 767_Hauschild_A._et_al._Longer_follow-up_confirms_relapse-free_survival_benefit_with_adjuvant_dabrafenib_plus_trametinib_in_patients_JCO_2018.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00393631f41ac7c8491c0de2c7f007a8Test
https://doi.org/10.5167/uzh-158265Test

المؤلفون: Céleste Lebbé, Anna Maria Di Giacomo, Helen Gogas, Georgina V. Long, Paolo A. Ascierto, Catalin Mihalcioiu, Francesco Cognetti, Ewa Kalinka-Warzocha, Kerry J. Savage, Cornelia Mauch, Ana Arance, Jasmine I. Rizzo, Lars Ny, Caroline Dutriaux, Piotr Rutkowski, Caroline Robert, Micaela Hernberg, Victoria Atkinson, Vanna Chiarion-Sileni, Benjamin Brady, Inge Marie Svane, Dirk Schadendorf, Jessica C. Hassel, Julie Charles, Laurent Mortier, Catriona M. McNeil, Abdel Saci, Joel Jiang

المصدر: JAMA Oncol

مصطلحات موضوعية: advanced melanoma, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Time Factors, Adolescent, Dacarbazine, Medizin, Phases of clinical research, Ipilimumab, Pembrolizumab, Placebo, BRAF, Young Adult, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Double-Blind Method, Internal medicine, medicine, Humans, 030212 general & internal medicine, Nivolumab, wild-type, Antineoplastic Agents, Alkylating, Melanoma, Aged, Aged, 80 and over, business.industry, Hazard ratio, Correction, Middle Aged, medicine.disease, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c9b0d0b1e4e0e7e07096a725b4e567Test
https://doi.org/10.1001/jamaoncol.2018.4514Test

المؤلفون: Daniil Stroyakovskiy, Peter Mohr, Virginia Ferraresi, Michael Millward, Paul Nathan, Claus Garbe, Filippo de Braud, Caroline Robert, Jhangir G. Irani, Igor Bondarenko, Vanna Chiarion-Sileni, Jochen Utikal, Nadezhda Kovalenko, Douglas J Demarini, Bijoyesh Mookerjee, James Larkin, Ana Arance, Suzanne Swann, Mario Mandalà, Axel Hauschild, Jeffrey J. Legos, John B. A. G. Haanen, Jean-Jacques Grob, Keith T. Flaherty, Antoni Ribas, Johan Hansson, Dirk Schadendorf, Georgina V. Long, Thomas Jouary, Helen Gogas, Fan Jin, Volodymr Probachai, Céleste Lebbé, Evgeny Levchenko

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Oncology, medicine.medical_specialty, Pyridones, Medizin, Phases of clinical research, Pyrimidinones, Placebo, Disease-Free Survival, Young Adult, chemistry.chemical_compound, Double-Blind Method, Internal medicine, Oximes, medicine, Clinical endpoint, Humans, Melanoma, Aged, Aged, 80 and over, Trametinib, Cobimetinib, business.industry, Hazard ratio, Imidazoles, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, Treatment Outcome, chemistry, Drug Therapy, Combination, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7305a840ef7860ce6dbedc881e5fe7cfTest
http://hdl.handle.net/11391/1480871Test

المؤلفون: Victoria Atkinson, Céleste Lebbé, Jessica C. Hassel, Catalin Mihalcioiu, Cornelia Mauch, Ewa Kalinka-Warzocha, Ian M. Waxman, Ana Arance, Piotr Rutkowski, Kerry J. Savage, Vanna Chiarion-Sileni, Caroline Dutriaux, Micaela Hernberg, Abstr Act, Laurent Mortier, Catriona M. McNeil, Brian Sharkey, Caroline Robert, Dirk Schadendorf, Michele Maio, Christine Horak, Georgina V. Long, Lotta Lundgren-Eriksson, Benjamin Brady, Helen Gogas, Francesco Cognetti, Henrik Schmidt, Paolo A. Ascierto, Julie Charles

المصدر: Robert, C, Long, G V, Brady, B, Dutriaux, C, Maio, M, Mortier, L, Hassel, J C, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Savage, K J, Hernberg, M M, Lebbé, C, Charles, J, Mihalcioiu, C, Chiarion-Sileni, V, Mauch, C, Cognetti, F, Arance, A, Schmidt, H, Schadendorf, D, Gogas, H, Lundgren-Eriksson, L, Horak, C, Sharkey, B, Waxman, I M, Atkinson, V & Ascierto, P A 2015, ' Nivolumab in previously untreated melanoma without BRAF mutation ', The New England Journal of Medicine, vol. 372, no. 4, pp. 320-30 . https://doi.org/10.1056/NEJMoa1412082Test
New England Journal of Medicine; 372(4), pp 320-330 (2015)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Dacarbazine, Programmed Cell Death 1 Receptor, Medizin, Phases of clinical research, Ipilimumab, Antineoplastic Agents, Pembrolizumab, ipilimumab-refractory metastatic melanoma, Gastroenterology, Disease-Free Survival, Young Adult, Double-Blind Method, Nivolumab, melanoma, ipilimumab-refractory metastatic melanoma, Internal medicine, Medicine, Humans, Survival rate, Melanoma, Aged, Aged, 80 and over, business.industry, Hazard ratio, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Surgery, Survival Rate, Nivolumab, Cancer and Oncology, Female, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07253c758028e0b62a420832a391b6ecTest
https://pubmed.ncbi.nlm.nih.gov/25511188Test

المؤلفون: Daniil Stroyakovskiy, Jochen Utikal, Keith T. Flaherty, Daniele Ouellet, Virginia Ferraresi, Michelle Casey, Claus Garbe, Axel Hauschild, V. Chiarion Sileni, Caroline Robert, Helen Gogas, Antoni Ribas, Michael Millward, Nadezhda Kovalenko, Jean-Jacques Grob, Jhangir G. Irani, Paul Nathan, Dirk Schadendorf, John B. A. G. Haanen, V. Probachai, Mario Mandalà, F. de Braud, Johan Hansson, Georgina V. Long, Igor Bondarenko, Kiran Patel, Ngocdiep T. Le, Anne-Marie Martin, James Larkin, Ana Arance, T. Jouary, Peter Mohr, Douglas J. DeMarini, Céleste Lebbé, Evgeny Levchenko

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Fever, Pyridones, Medizin, Kaplan-Meier Estimate, Pyrimidinones, Gastroenterology, Disease-Free Survival, chemistry.chemical_compound, Double-Blind Method, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Carcinoma, medicine, Clinical endpoint, Humans, Melanoma, Aged, Mitogen-Activated Protein Kinase Kinases, Cobimetinib, Trametinib, business.industry, Hazard ratio, Imidazoles, Binimetinib, Dabrafenib, General Medicine, Middle Aged, medicine.disease, Surgery, chemistry, Mutation, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::266d13e0581ba3c486d28c2d159ca1daTest
http://hdl.handle.net/11391/1480877Test

المؤلفون: Marta Nyakas, Stuart Spencer, Mireille Cantarini, Reinhard Dummer, Gabriella Liszkay, Paul Lorigan, Ana Arance, Caroline Robert, Mark R. Middleton, Dirk Schadendorf, Ralf Gutzmer, Kevin B. Kim

المساهمون: University of Zurich, Robert, Caroline

مصطلحات موضوعية: Male, Skin Neoplasms, Time Factors, medicine.medical_treatment, DNA Mutational Analysis, Medizin, Phases of clinical research, Kaplan-Meier Estimate, Gastroenterology, Antineoplastic Combined Chemotherapy Protocols, Melanoma, 10177 Dermatology Clinic, Middle Aged, Dacarbazine, Europe, Phenotype, Treatment Outcome, Oncology, Tolerability, Female, 2730 Oncology, Brazil, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, 610 Medicine & health, Neutropenia, Placebo, Disease-Free Survival, Drug Administration Schedule, Double-Blind Method, Internal medicine, medicine, Humans, Genetic Predisposition to Disease, Antineoplastic Agents, Alkylating, Protein Kinase Inhibitors, Aged, Proportional Hazards Models, Chemotherapy, Intention-to-treat analysis, business.industry, medicine.disease, United States, Surgery, Logistic Models, Mutation, Selumetinib, Neoplasms, Unknown Primary, Benzimidazoles, business

وصف الملف: 555_Robert_C_et_al._-_Lancet_Oncol_2013.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c63162f2b90b77be9846693c33b4197Test
https://www.ncbi.nlm.nih.gov/pubmed/23735514Test