نتائج البحث

المصدر: European Journal of Clinical Pharmacology
Ogungbenro, K, Wagner, J B, Abdel-Rahman, S, Leeder, J S & Galetin, A 2019, ' A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents ', European journal of clinical pharmacology . https://doi.org/10.1007/s00228-019-02697-yTest, https://doi.org/10.1007/s00228-019-02697-yTest

مصطلحات موضوعية: Male, Simvastatin, Metabolite, Pharmacology, 030226 pharmacology & pharmacy, chemistry.chemical_compound, 0302 clinical medicine, population pharmacokinetics, polycyclic compounds, Metabolites, Cytochrome P-450 CYP3A, Pharmacology (medical), 030212 general & internal medicine, Population pharmacokinetics, Child, metabolites, education.field_of_study, biology, Liver-Specific Organic Anion Transporter 1, General Medicine, children and adolescents, lipids (amino acids, peptides, and proteins), Female, medicine.drug, Adult, Children and adolescents, Adolescent, Genotype, Population, Hyperlipidemias, Models, Biological, Modelling, modelling, 03 medical and health sciences, Young Adult, Pharmacokinetics, medicine, Humans, cardiovascular diseases, Dosing, education, CYP3A5, Active metabolite, business.industry, organic chemicals, nutritional and metabolic diseases, Pharmacokinetics and Disposition, chemistry, biology.protein, Hydroxymethylglutaryl-CoA Reductase Inhibitors, SLCO1B1, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699bc3230303aacd3a9c86415f651c74Test
http://europepmc.org/articles/PMC6697721Test

6

Genotypes Predispose Phenotypes—Clinical Features and Genetic Spectrum of ABCA4-Associated Retinal Dystrophies

المؤلفون: Chao-Wen Lin, Chang-Hao Yang, Chung-May Yang, Ding-Siang Huang, Ta-Ching Chen, Fung-Rong Hu, Yu-Chi Sung, Pei-Lung Chen, Yu-Shu Huang

المصدر: Genes
Genes, Vol 11, Iss 1421, p 1421 (2020)
Volume 11
Issue 12

مصطلحات موضوعية: 0301 basic medicine, Retinal degeneration, Male, Pathology, Fovea Centralis, ABCA4, Diagnostic Techniques, Ophthalmological, chemistry.chemical_compound, 0302 clinical medicine, Ethnicity, Medicine, Stargardt Disease, Child, Genetics (clinical), education.field_of_study, biology, inherited retinal degeneration, High-Throughput Nucleotide Sequencing, genotype–phenotype correlation, Middle Aged, Child, Preschool, Female, Retinal Dystrophies, Adult, medicine.medical_specialty, lcsh:QH426-470, Adolescent, Genotype, Fundus Oculi, Population, Taiwan, Article, 03 medical and health sciences, Genetic Heterogeneity, Young Adult, retinitis pigmentosa, Retinitis pigmentosa, Genetics, Humans, Genetic Predisposition to Disease, education, Genetic Association Studies, Aged, business.industry, Dystrophy, Retinal, Stargardt disease 1, medicine.disease, Stargardt disease, lcsh:Genetics, 030104 developmental biology, chemistry, 030221 ophthalmology & optometry, biology.protein, ATP-Binding Cassette Transporters, business, Cone-Rod Dystrophies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc703a68fbfc36500befb24b7e211f0Test
http://europepmc.org/articles/PMC7759801Test

7

Human precision-cut liver slices as a model to test antifibrotic drugs in the early onset of liver fibrosis

المؤلفون: Peter Olinga, Inge M. Westra, Henricus A. M. Mutsaers, Dorenda Oosterhuis, Koert P. de Jong, Geny M. M. Groothuis, Mackenzie Hadi, Theerut Luangmonkong

المساهمون: Pharmaceutical Technology and Biopharmacy, Nanomedicine & Drug Targeting, Groningen Institute for Organ Transplantation (GIOT), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Biopharmaceuticals, Discovery, Design and Delivery (BDDD)

المصدر: Toxicology in Vitro, 35, 77-85. PERGAMON-ELSEVIER SCIENCE LTD

مصطلحات موضوعية: Liver Cirrhosis, Male, 0301 basic medicine, Pyridines, Gene Expression, Pharmacology, Toxicology, p38 Mitogen-Activated Protein Kinases, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Child, Heat shock protein 47, GENE-EXPRESSION, Aged, 80 and over, biology, MOLECULAR-MECHANISMS, ANTI-FIBROTIC DRUGS, Imidazoles, TGF-BETA, General Medicine, Pirfenidone, Middle Aged, PHASE-I, Liver, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, Human precision-cut liver slices, medicine.medical_specialty, Adolescent, Liver fibrosis, IMATINIB MESYLATE, HEPATIC STELLATE CELLS, In Vitro Techniques, Collagen Type I, Young Adult, 03 medical and health sciences, IN-VITRO MODEL, Internal medicine, medicine, Humans, HSP47 Heat-Shock Proteins, Protein Kinase Inhibitors, Aged, business.industry, Transforming growth factor beta, ROSMARINIC ACID, medicine.disease, Collagen Type I, alpha 1 Chain, Tetrandrine, Collagen, type I, alpha 1, 030104 developmental biology, Endocrinology, Imatinib mesylate, chemistry, Hepatic stellate cell, biology.protein, IDIOPATHIC PULMONARY-FIBROSIS, Antifibrotic, business