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المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Regulator, General Physics and Astronomy, mTORC1, Inbred C57BL, Muscle Development, Hydroxylation, chemistry.chemical_compound, Mice, 0302 clinical medicine, Amino Acids, lcsh:Science, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, Muscles, Amino acid, Cell biology, Mechanisms of disease, TOR signalling, Female, Leucine, Signal transduction, biological phenomena, cell phenomena, and immunity, Signal Transduction, Gene isoform, Adult, Knockout, Science, Procollagen-Proline Dioxygenase, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Article, General Biochemistry, Genetics and Molecular Biology, Hypoxia-Inducible Factor-Proline Dioxygenases, 03 medical and health sciences, Clinical Research, Animals, Humans, Aged, Animal, Leucyl-tRNA synthetase, General Chemistry, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, chemistry, Preclinical research, General Biochemistry, Disease Models, lcsh:Q, Leucine-tRNA Ligase, 030217 neurology & neurosurgery

وصف الملف: Electronic; application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed65d3a9ba21caa35226b725b5c4e464Test
https://doaj.orgTest/article/57ce964136154da49cd0e8f1b72242c1

7

Genomic and immune profiling of pre-invasive lung adenocarcinoma

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-6 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, Receptor, ErbB-2, MAP Kinase Kinase 1, Loss of Heterozygosity, General Physics and Astronomy, medicine.disease_cause, Loss of heterozygosity, 0302 clinical medicine, HLA Antigens, lcsh:Science, Exome, Exome sequencing, Cancer, Aged, 80 and over, Multidisciplinary, RNA-Binding Proteins, Middle Aged, Proto-Oncogene Proteins c-met, 3. Good health, ErbB Receptors, 030220 oncology & carcinogenesis, Adenocarcinoma, Female, KRAS, Adult, Proto-Oncogene Proteins B-raf, DNA Copy Number Variations, Science, Receptors, Antigen, T-Cell, Receptors, Antigen, B-Cell, Adenocarcinoma of Lung, Adenocarcinoma in Situ, Human leukocyte antigen, Biology, Malignancy, Article, General Biochemistry, Genetics and Molecular Biology, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Exome Sequencing, Genetics, medicine, Humans, Neoplasm Invasiveness, neoplasms, Aged, Gene Expression Profiling, General Chemistry, medicine.disease, digestive system diseases, Gene expression profiling, 030104 developmental biology, Mutation, Cancer research, lcsh:Q, Tumor Suppressor Protein p53

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e869032752dccbe620cc15973c500df4Test
http://link.springer.comTest/article/10.1038/s41467-019-13460-3

8

Liquid biopsy-based single-cell metabolic phenotyping of lung cancer patients for informative diagnostics

المؤلفون: Yu Dong, Ziming Li, Chunying Wang, Qihui Shi, Yin Tang, Jie Chen, Shun Lu, Baojun Wu, Xiang Lu, Zhuo Wang, Min Xue, Liu Yang, Zhili Guo, Wei Wei

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications

مصطلحات موضوعية: Male, 0301 basic medicine, Lung Neoplasms, medicine.medical_treatment, General Physics and Astronomy, Cell Count, Kaplan-Meier Estimate, 02 engineering and technology, B7-H1 Antigen, Targeted therapy, Transcriptome, lcsh:Science, Aged, 80 and over, Multidisciplinary, Biological techniques, Middle Aged, Prognosis, 021001 nanoscience & nanotechnology, Cancer metabolism, Cell killing, Adenocarcinoma, Female, Single-Cell Analysis, 0210 nano-technology, Adult, Tumour heterogeneity, Science, Adenocarcinoma of Lung, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Medical research, Proto-Oncogene Proteins, Biomarkers, Tumor, medicine, Humans, Metabolomics, Liquid biopsy, Lung cancer, Aged, business.industry, Gene Expression Profiling, Liquid Biopsy, Receptor Protein-Tyrosine Kinases, General Chemistry, Microarray Analysis, Programmed Cell Death 1 Ligand 2 Protein, medicine.disease, Axl Receptor Tyrosine Kinase, Immune checkpoint, Pleural Effusion, Malignant, 030104 developmental biology, Cancer research, lcsh:Q, business, Non-small-cell lung cancer, Cytometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2a2ec472bb45bd704b980482fcddd5Test
https://doaj.orgTest/article/fc6306e74458427db8cad26bd5b3ccb6

9

Genomic and transcriptomic correlates of immunotherapy response within the tumor microenvironment of leptomeningeal metastases

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Male, Oncology, medicine.medical_treatment, Programmed Cell Death 1 Receptor, Cell, General Physics and Astronomy, Phases of clinical research, Cancer immunotherapy, CD8-Positive T-Lymphocytes, Metastasis, Transcriptome, Meningeal Neoplasms, Tumor Microenvironment, CTLA-4 Antigen, Immune Checkpoint Inhibitors, Multidisciplinary, Brain Neoplasms, Genomics, Middle Aged, Gene Expression Regulation, Neoplastic, Nivolumab, medicine.anatomical_structure, Female, Immunotherapy, Single-Cell Analysis, Cell-Free Nucleic Acids, Meningeal Carcinomatosis, Adult, medicine.medical_specialty, Science, Antibodies, Monoclonal, Humanized, Article, General Biochemistry, Genetics and Molecular Biology, Interferon-gamma, Immune system, Internal medicine, medicine, Humans, Author Correction, Aged, Tumor microenvironment, business.industry, Cancer, General Chemistry, medicine.disease, Ipilimumab, Survival Analysis, CNS cancer, business, Complication

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb72fe3e755cd241f760855642150313Test
https://doi.org/10.1038/s41467-021-25860-5Test

10

GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

المؤلفون: Claudia Langenberg, Po-Ru Loh, John R. B. Perry, Yajie Zhao, Maik Pietzner, Felix R. Day, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Nicola D. Kerrison, Nicholas J. Wareham, Ken K. Ong, Hana Lango Allen

المساهمون: Zhao, Yajie [0000-0002-2747-0219], Stankovic, Stasa [0000-0002-6602-1379], Wheeler, Eleanor [0000-0002-8616-6444], Day, Felix R [0000-0003-3789-7651], Pietzner, Maik [0000-0003-3437-9963], Loh, Po-Ru [0000-0001-5542-9064], Wareham, Nicholas J [0000-0003-1422-2993], Langenberg, Claudia [0000-0002-5017-7344], Ong, Ken K [0000-0003-4689-7530], Perry, John R B [0000-0001-6483-3771], Apollo - University of Cambridge Repository, Perry, John RB [0000-0001-6483-3771], Day, Felix R. [0000-0003-3789-7651], Wareham, Nicholas J. [0000-0003-1422-2993], Ong, Ken K. [0000-0003-4689-7530], Perry, John R. B. [0000-0001-6483-3771]

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Nature Communications

مصطلحات موضوعية: Male, DNA Mutational Analysis, 45/43, General Physics and Astronomy, Genome-wide association study, Type 2 diabetes, Genome-wide association studies, Whole Exome Sequencing, Receptor, IGF Type 1, 0302 clinical medicine, Loss of Function Mutation, Leukocytes, Insulin, Exome, Exome sequencing, Genetics, 0303 health sciences, Multidisciplinary, Mosaicism, article, Middle Aged, humanities, 631/208/211, Female, Signal Transduction, Genomic instability, Adult, Science, 631/208/205/2138, Biology, General Biochemistry, Genetics and Molecular Biology, 692/163/2743/137/773, 03 medical and health sciences, Exome Sequencing, medicine, Humans, Genetic Predisposition to Disease, Allele, Loss function, 030304 developmental biology, Genetic association, Aged, Chromosomes, Human, Y, 45, Case-control study, General Chemistry, medicine.disease, Diabetes Mellitus, Type 2, Case-Control Studies, Carrier Proteins, 030217 neurology & neurosurgery, Genome-Wide Association Study

وصف الملف: application/pdf; application/zip; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbd6d6f83cdc52256864ab0469d4aa4Test

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