نتائج البحث

1

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

المؤلفون: Snuggs J, Shannon N. Tessier, Makarand V. Risbud, Irving M. Shapiro, R A B Bunning, C. L. Le Maitre

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cell biology, Nucleus Pulposus, Molecular biology, Science, Primary Cell Culture, Aquaporin, Intervertebral Disc Degeneration, Article, Mice, 03 medical and health sciences, Rheumatic diseases, Chondrocytes, 0302 clinical medicine, Downregulation and upregulation, Enhancer binding, Gene expression, Animals, Humans, RNA, Small Interfering, Rats, Wistar, Mice, Knockout, Gene knockdown, Multidisciplinary, Aquaporin 1, Osmotic concentration, Chemistry, Osmolar Concentration, Middle Aged, Aquaporin 5, Rats, Mice, Inbred C57BL, Mechanisms of disease, 030104 developmental biology, Gene Expression Regulation, Tonicity, Medicine, Female, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee143d3c36cf2973f715cac5f156fecTest
https://doaj.orgTest/article/4138b596e4be471abac6b99852763239

2

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

المؤلفون: Aviv Regev, Eugene Drokhlyansky, Jozef Ukropec, Christian Wolfrum, Lucia Balazova, Gottfried Rudofsky, Wenfei Sun, Antonio Giordano, Lianggong Ding, Miroslav Balaz, Anna Sofie Husted, Patrik Stefanicka, Georgia Colleluori, Michal Slyper, Saverio Cinti, Zuzana Kovanicova, Thue W. Schwartz, Hua Dong

المصدر: Cell Metab

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d0e829fb1d588b5e9be24e980e95e0Test
https://doi.org/10.1038/s41586-020-2856-xTest

3

Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms

المؤلفون: Licio A. Velloso, Ariane Maria Zanesco, Daiane F. Engel, Alexandre Moura-Assis, Athanasios Papangelis, Carina Solon, Vanessa Cristina Dias Bóbbo, Trond Ulven, Guilherme Nogueira, Natália Ferreira Mendes

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Engel, D F, Bobbo, V C D, Solon, C S, Nogueira, G A, Moura-Assis, A, Mendes, N F, Zanesco, A M, Papangelis, A, Ulven, T & Velloso, L A 2020, ' Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms ', Scientific Reports, vol. 10, no. 1, 11047 . https://doi.org/10.1038/s41598-020-68110-2Test

مصطلحات موضوعية: Male, STRESS, Pyridines, lcsh:Medicine, Ligands, Adult neurogenesis, p38 Mitogen-Activated Protein Kinases, Receptors, G-Protein-Coupled, Mice, Neurotrophic factors, Receptor, lcsh:Science, Neurons, Multidisciplinary, biology, Chemistry, Neurogenesis, Imidazoles, Neurochemistry, Cell biology, OBESITY, POMC NEURONS, FATTY-ACIDS, STEM-CELLS, endocrine system, Cell Survival, p38 mitogen-activated protein kinases, Models, Neurological, Hypothalamus, Article, Cell Line, Methylamines, ADULT, DIETARY, Neurosphere, Free fatty acid receptor 1, Animals, Protein Kinase Inhibitors, Cell Proliferation, Cell growth, Interleukin-6, Brain-Derived Neurotrophic Factor, lcsh:R, PROTEIN-KINASE, Doublecortin, Mice, Inbred C57BL, MICE, biology.protein, lcsh:Q, Propionates, NEUROTROPHIC FACTOR

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66eba08413780d00163a93b89857e3cTest
http://link.springer.comTest/article/10.1038/s41598-020-68110-2

4

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

المؤلفون: Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein

المساهمون: UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Regulator, General Physics and Astronomy, mTORC1, Inbred C57BL, Muscle Development, Hydroxylation, chemistry.chemical_compound, Mice, 0302 clinical medicine, Amino Acids, lcsh:Science, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, Muscles, Amino acid, Cell biology, Mechanisms of disease, TOR signalling, Female, Leucine, Signal transduction, biological phenomena, cell phenomena, and immunity, Signal Transduction, Gene isoform, Adult, Knockout, Science, Procollagen-Proline Dioxygenase, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Article, General Biochemistry, Genetics and Molecular Biology, Hypoxia-Inducible Factor-Proline Dioxygenases, 03 medical and health sciences, Clinical Research, Animals, Humans, Aged, Animal, Leucyl-tRNA synthetase, General Chemistry, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, chemistry, Preclinical research, General Biochemistry, Disease Models, lcsh:Q, Leucine-tRNA Ligase, 030217 neurology & neurosurgery

وصف الملف: Electronic; application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed65d3a9ba21caa35226b725b5c4e464Test
https://doaj.orgTest/article/57ce964136154da49cd0e8f1b72242c1

5

Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies

المؤلفون: Liffert Vogt, Carrie Ris-Stalpers, G. J. M. Veenboer, Stephan L. M. Peters, Fouad Amraoui, Gijs B. Afink, B.J.H. van den Born, H. Hassani Lahsinoui, N. van Vlies, Léon J. A. Spijkers

المساهمون: Obstetrics and Gynaecology, Graduate School, Amsterdam Reproduction & Development (AR&D), Pharmacology and pharmacotherapeutics, Nephrology, APH - Health Behaviors & Chronic Diseases, ACS - Microcirculation, General Paediatrics, Public and occupational health, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Reproductive Biology Laboratory, APH - Personalized Medicine, APH - Global Health, ACS - Heart failure & arrhythmias

المصدر: Scientific reports, 11(1):4387. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, medicine.medical_specialty, animal structures, Science, Dermatan Sulfate, Blood Pressure, 030204 cardiovascular system & hematology, Glycocalyx, Article, Thromboplastin, Syndecan 1, Preeclampsia, Glycosaminoglycan, Mice, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Animal disease models, Pregnancy, Internal medicine, medicine, Animals, Humans, 030212 general & internal medicine, Endothelial dysfunction, Fetus, Vascular Endothelial Growth Factor Receptor-1, Multidisciplinary, medicine.diagnostic_test, Chemistry, Translational research, medicine.disease, Mice, Inbred C57BL, carbohydrates (lipids), Endocrinology, Blood pressure, Keratan Sulfate, Vasoconstriction, embryonic structures, Medicine, Female, Heparitin Sulfate, Syndecan-1, Partial thromboplastin time

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dee20188384cd8588c720b47334fcd2Test
https://pure.amc.nl/en/publications/soluble-syndecan1-and-glycosaminoglycans-in-preeclamptic-and-normotensive-pregnanciesTest(d0591adb-ef6f-4a97-9d6e-35b9bdd94078).html

6

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

المؤلفون: Hiroshi Asahara, Yoshiaki Ito, Tokio Matsuzaki, Kohei Miyata, Tempei Sato, Martin Lotz, Ryo Nakamichi, Merissa Olmer, Eiji Sugiyama, Masafumi Inui, Sho Mokuda

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cartilage, Articular, CRISPR-Cas9 genome editing, Knee Joint, Ubiquitylation, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, 02 engineering and technology, Osteoarthritis, Menisci, Tibial, Mice, Ubiquitin, lcsh:Science, Aged, 80 and over, Mice, Knockout, Multidisciplinary, biology, Cartilage homeostasis, Chemistry, Middle Aged, 021001 nanoscience & nanotechnology, musculoskeletal system, Ubiquitin ligase, Cell biology, RUNX2, medicine.anatomical_structure, miRNAs, 0210 nano-technology, Signal Transduction, Adult, musculoskeletal diseases, Ubiquitin-Protein Ligases, Science, WWP2, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Animals, Humans, RNA, Messenger, Aged, Cartilage, Skull, Ubiquitination, General Chemistry, X-Ray Microtomography, medicine.disease, Arthritis, Experimental, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:Q, ADAMTS5 Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c9bffffe46cfae2df3f937bdfb3f0Test
http://link.springer.comTest/article/10.1038/s41467-019-10177-1

7

Cytoplasmic LIF reprograms invasive mode to enhance NPC dissemination through modulating YAP1-FAK/PXN signaling

المؤلفون: Chiou-Hwa Yuh, Shih Sheng Jiang, Chun Nan OuYang, Ngan Ming Tsang, Shu Chen Liu, Tien Hsu, An Ko Chung, Yu-Sun Chang, Ya Ping Liu, Chuen Hsueh

المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, General Physics and Astronomy, Mice, SCID, Leukemia Inhibitory Factor, Metastasis, Mice, Neoplasm Metastasis, lcsh:Science, reproductive and urinary physiology, YAP1, Aged, 80 and over, Multidisciplinary, Nasopharyngeal Carcinoma, Kinase, Chemistry, Signal transducing adaptor protein, Middle Aged, Immunohistochemistry, embryonic structures, Female, hormones, hormone substitutes, and hormone antagonists, Signal Transduction, Adult, endocrine system, Epithelial-Mesenchymal Transition, Receptors, OSM-LIF, Science, Blotting, Western, General Biochemistry, Genetics and Molecular Biology, Article, Focal adhesion, 03 medical and health sciences, Young Adult, medicine, Human Umbilical Vein Endothelial Cells, otorhinolaryngologic diseases, Animals, Humans, Neoplasm Invasiveness, Adaptor Proteins, Signal Transducing, Aged, urogenital system, Cancer, Nasopharyngeal Neoplasms, YAP-Signaling Proteins, General Chemistry, medicine.disease, Phosphoproteins, Xenograft Model Antitumor Assays, stomatognathic diseases, 030104 developmental biology, Nasopharyngeal carcinoma, Focal Adhesion Kinase 1, Cancer research, lcsh:Q, Paxillin, Leukemia inhibitory factor, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de69d2972cda5f8e3890c7fa1222a2d4Test
http://link.springer.comTest/article/10.1038/s41467-018-07660-6

8

Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway

المؤلفون: Zhong-Fa Lu, Lijuan Zhou, Jing Jing, Lijuan Yu, Han Wang, Xian-Jie Wu

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, Lymphoid Enhancer-Binding Factor 1, Cell, lcsh:Medicine, Outer root sheath, Article, 03 medical and health sciences, Mice, Young Adult, Cornus, Downregulation and upregulation, Proto-Oncogene Proteins, medicine, Loose Anagen Hair Syndrome, Animals, Humans, Glycosides, lcsh:Science, Wnt Signaling Pathway, Cells, Cultured, beta Catenin, Cell Proliferation, Multidisciplinary, integumentary system, Chemistry, lcsh:R, Wnt signaling pathway, Alopecia, Middle Aged, medicine.disease, In vitro, Cell biology, Mice, Inbred C57BL, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, Hair loss, DKK1, Intercellular Signaling Peptides and Proteins, Female, lcsh:Q, Signal transduction, Hair Follicle, Hair

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc56d7aadcf4f24e2d2ceda364521b79Test
http://link.springer.comTest/article/10.1038/s41598-018-32138-2

9

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder

المؤلفون: Akihiro Mouri, Kuniaki Saito, Toshitaka Nabeshima, Hiroyuki Kimura, Tomoya Miyauchi, Takashi Tonoike, Norio Ozaki, Eri Umemura, Yasuko Yamamoto, Hidetoshi Matsunami, Masashi Sakurai, Noriyo Kanayama, Kenichi Kurita, Masaya Hasegawa, Wataru Nagashima, Masao Takemura, Aiji Sato Boku, Mikiko Ito, Tatsuya Tokura

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports

مصطلحات موضوعية: Male, 0301 basic medicine, Kynurenine pathway, Metabolite, 3-Hydroxyanthranilic Acid, lcsh:Medicine, Kynurenic Acid, Mice, chemistry.chemical_compound, 0302 clinical medicine, Kynurenic acid, ortho-Aminobenzoates, lcsh:Science, Kynurenine, Multidisciplinary, Depression, Tryptophan, Chronic pain, Middle Aged, Healthy Volunteers, Metabolome, Biomarker (medicine), Major depressive disorder, Female, Chronic Pain, Adult, medicine.medical_specialty, Predictive markers, Article, 03 medical and health sciences, Internal medicine, medicine, Animals, Humans, Psychiatric Status Rating Scales, Depressive Disorder, Major, business.industry, lcsh:R, Case-control study, medicine.disease, Disease Models, Animal, Interleukin 1 Receptor Antagonist Protein, 030104 developmental biology, Endocrinology, chemistry, Case-Control Studies, lcsh:Q, business, Biomarkers, Stress, Psychological, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a338e9597555d6f19213b395d5e7bcaTest
https://doi.org/10.1038/s41598-020-58806-wTest

10

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia

المؤلفون: Alejandra Ortiz-Ruiz, Alicia Arenas, Nerea Castro, Ivana Zagorac, Inmaculada Rapado, María Luz Morales, Alba Rodríguez-García, Miguel Gallardo, Rosa Ayala, Alejandra Leivas, Miguel Quintela-Fandino, María Linares, Gonzalo Gómez-López, Joaquin Martinez-Lopez

المساهمون: Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), CRIS Foundation, Sociedad Española de Hematología y Hemoterapia, UAM. Departamento de Bioquímica

المصدر: Repisalud
Instituto de Salud Carlos III (ISCIII)
Scientific Reports
Biblos-e Archivo. Repositorio Institucional de la UAM
Universidade de Vigo (UVigo)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid

مصطلحات موضوعية: Male, 0301 basic medicine, Myeloid, lcsh:Medicine, Antigens, CD34, Mice, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Midostaurin, lcsh:Science, Trametinib, Multidisciplinary, MEK inhibitor, Myeloid leukemia, Drug Synergism, Middle Aged, Leukemia, Myeloid, Acute, Cancer therapeutic resistance, Leukemia, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Female, Tyrosine kinase, Adult, Trasnational research, MAP Kinase Signaling System, Pyridones, Medicina, MAP Kinase Kinase Kinase 1, Bone Marrow Cells, Pyrimidinones, Cancer therapeutic resistence, Article, 03 medical and health sciences, Targeted therapies, Cell Line, Tumor, medicine, Animals, Humans, Protein Kinase Inhibitors, Aged, business.industry, lcsh:R, Translational research, Staurosporine, medicine.disease, 030104 developmental biology, fms-Like Tyrosine Kinase 3, chemistry, Drug Resistance, Neoplasm, Cancer research, lcsh:Q, business, Ex vivo

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc980651ce70600f734d839545483dfTest
https://hdl.handle.net/20.500.12105/9353Test

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