نتائج البحث

1

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

المؤلفون: Kefu Wu, Xiaolin Yang, Kaifeng Shen, Yu-Jia Wei, Shi-Yong Liu, Jiong Yue, Jiaojiang He, Hui Yang, Chun-Qing Zhang

المصدر: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Journal of Neuroinflammation

مصطلحات موضوعية: Male, Pathology, Pyrrolidines, Anti-Inflammatory Agents, Hippocampus, Convulsants, lcsh:RC346-429, Mice, Status Epilepticus, Neuroinflammation, Gliosis, Temporal lobe epilepsy, Neocortex, TUNEL assay, Microglia, Neuronal apoptosis, General Neuroscience, Pilocarpine, Temporal Lobe, medicine.anatomical_structure, Neuroprotective Agents, Rev-Erbα, Neurology, Cytokines, Encephalitis, medicine.symptom, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Immunology, Status epilepticus, Thiophenes, Biology, Neuroprotection, Cellular and Molecular Neuroscience, Young Adult, medicine, Animals, Humans, lcsh:Neurology. Diseases of the nervous system, Research, NLRP3 inflammasome, Mice, Inbred C57BL, Epilepsy, Temporal Lobe, Gene Expression Regulation, nervous system, Nuclear Receptor Subfamily 1, Group D, Member 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a749cea093b9b3eda68c93cc429703bTest
https://doaj.org/article/a24c5daa2e23441fb73fa685c2ac36bcTest

2

Endothelial BMPR2 Loss Drives a Proliferative Response to BMP (Bone Morphogenetic Protein) 9 via Prolonged Canonical Signaling

المؤلفون: L. Rhiannon Hilton, Jodi L. MacKeil, Jeffrey Mewburn, Paula D. James, Devon V. Cole, Mark L. Ormiston, Donald H. Maurice, Anne L. Theilmann, Mara K.M. Whitford, Lindsey G. Hawke, Kimberly J. Dunham-Snary, Stephen L. Archer

المصدر: Arteriosclerosis, Thrombosis, and Vascular Biology

مصطلحات موضوعية: Adult, Male, hypertension, pulmonary, GDF2, Biology, Bone Morphogenetic Protein Receptors, Type II, Angiogenesis Modulating Agents, Vascular occlusion, lung, Young Adult, inhibitor of differentiation protein 1, medicine, Growth Differentiation Factor 2, Animals, Humans, Gene, Cells, Cultured, Aged, Cell Proliferation, Mice, Knockout, Pulmonary Arterial Hypertension, Lung, Basic Sciences, Endothelial Cells, Middle Aged, medicine.disease, Pulmonary hypertension, Proliferative response, BMPR2, Mice, Inbred C57BL, medicine.anatomical_structure, angiogenesis modulating agents, Case-Control Studies, Cancer research, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Female, Inhibitor of Differentiation Proteins, medicine.symptom, Cardiology and Cardiovascular Medicine, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270dc623528f30db6d6ebc25c01717faTest
http://europepmc.org/articles/PMC7571847Test

3

Association of high HIF-1α levels in serous periodontitis with external root resorption by the NFATc1 pathway

المؤلفون: Chang-Jie Xiao, Xijiao Yu, Yanmei Du, Huan Jiang, Guangliang Bai

المصدر: Journal of Molecular Histology. 51:649-658

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Histology, Lipopolysaccharide, Physiology, Gene Expression, Osteoclasts, Severity of Illness Index, Severe periodontitis, Bone resorption, Mice, 03 medical and health sciences, chemistry.chemical_compound, medicine, Animals, Humans, Hypoxia, Periodontitis, Porphyromonas gingivalis, Aged, NFATC Transcription Factors, 030102 biochemistry & molecular biology, biology, business.industry, Cell Differentiation, Cell Biology, General Medicine, Middle Aged, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, biology.organism_classification, Resorption, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, chemistry, Female, Disease Susceptibility, Bone marrow, medicine.symptom, business, Biomarkers, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24824204692ccc6569f2ab0654ca45aeTest
https://doi.org/10.1007/s10735-020-09911-7Test

4

HIF-1α is involved in blood–brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis

المؤلفون: Sven Hammerschmidt, Karl H. Plate, Roland Nau, Kavi Devraj, Daniel Spitzer, Sylvaine Guérit, Jadranka Macas, Stefan Günther, Maryam I Khel, Camelia M. Monoranu, Michel Mittelbronn, Anne K. Braczynski, Roxana Heidemann, Omolara O. Ogunshola, Gayatri Devraj, Jana Seele, Volkhard A. J. Kempf, Uwe Ködel, Wibke Ballhorn

المساهمون: University of Zurich, Devraj, Kavi, Kempf, Volkhard A J

المصدر: Acta Neuropathologica

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, 2804 Cellular and Molecular Neuroscience, medicine.disease_cause, Dexamethasone, Mice, chemistry.chemical_compound, Blood–brain barrier (BBB), Aged, 80 and over, Meningitis, Pneumococcal, Middle Aged, 10081 Institute of Veterinary Physiology, VEGF, Vascular endothelial growth factor, 2728 Neurology (clinical), Streptococcus pneumoniae, medicine.anatomical_structure, Blood-Brain Barrier, Female, medicine.symptom, Meningitis, medicine.drug, Adult, Paracellular transmigration, Endothelium, Clinical Neurology, HIF-1α, Brain damage, Blood–brain barrier, Permeability, Pathology and Forensic Medicine, Cerebral edema, Cellular and Molecular Neuroscience, medicine, HIF, Animals, Humans, Aged, Original Paper, business.industry, Transendothelial and Transepithelial Migration, 1α, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, S. pneumoniae, 2734 Pathology and Forensic Medicine, Mice, Inbred C57BL, chemistry, Cancer research, 570 Life sciences, biology, Neurology (clinical), business

وصف الملف: Devraj_Acta_Neuropathologica_2020.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abfaa7c452c7a21075e40e2f6ba582cTest
https://doi.org/10.1007/s00401-020-02174-2Test

5

Host engulfment pathway controls inflammation in inflammatory bowel disease

المؤلفون: Stella-Rita Ibeawuchi, Matheus Pereira, Ranajoy Chattopadhyay, Gajanan D. Katkar, Pradipta Ghosh, Eileen Lim, Sujay Singh, Brigid S. Boland, Soumita Das, William J. Sandborn, Monica Guma, Ying Dunkel, Yash Mittal, Parambir S. Dulai, Ibrahim M Sayed, Katherine Suarez

المصدر: FEBS J
The FEBS journal, vol 287, iss 18

مصطلحات موضوعية: Male, 0301 basic medicine, THP-1 Cells, medicine.medical_treatment, Crohn's Disease, Medical Biochemistry and Metabolomics, Inbred C57BL, Biochemistry, Inflammatory bowel disease, Oral and gastrointestinal, Mice, 0302 clinical medicine, enteroid, 2.1 Biological and endogenous factors, Aetiology, Intestinal Mucosa, Mice, Knockout, Adaptor Proteins, epithelial-immune cell crosstalk, Middle Aged, Colitis, Organoids, medicine.anatomical_structure, ELMO1, Cytokine, 030220 oncology & carcinogenesis, Host-Pathogen Interactions, Cytokines, Female, Tumor necrosis factor alpha, medicine.symptom, Adult, Biochemistry & Molecular Biology, Knockout, Inflammation, Autoimmune Disease, Article, Medicinal and Biomolecular Chemistry, Young Adult, 03 medical and health sciences, inflammatory bowel disease, medicine, Animals, Humans, Molecular Biology, Adaptor Proteins, Signal Transducing, Aged, Lamina propria, business.industry, Inflammatory and immune system, Monocyte, Signal Transducing, monocyte chemoattractant protein 1, Cell Biology, Inflammatory Bowel Diseases, medicine.disease, Epithelium, Mice, Inbred C57BL, microbial sensing and bacterial engulfment, 030104 developmental biology, Gene Expression Regulation, Immunology, Citrobacter rodentium, Biochemistry and Cell Biology, Digestive Diseases, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85bf2fb0feaf80489a05fa877731f4cbTest
https://doi.org/10.1111/febs.15236Test

6

CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression

المؤلفون: Xin Yin, Zhipei Zhang, Ying Sun, Jinghua Xia

المصدر: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-11 (2020)
BMC Pulmonary Medicine

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, Male, Lung Neoplasms, CHCHD2, Cell, HIF-1α, Prognostic, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, Non-small cell lung cancer, Carcinoma, Non-Small-Cell Lung, Biomarkers, Tumor, Medicine, Animals, Humans, Survival analysis, 030304 developmental biology, Aged, Neoplasm Staging, Aged, 80 and over, lcsh:RC705-779, 0303 health sciences, business.industry, Proportional hazards model, Hazard ratio, lcsh:Diseases of the respiratory system, Hypoxia (medical), Middle Aged, medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, Immunohistochemistry, Survival Analysis, Blot, DNA-Binding Proteins, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Lymphatic Metastasis, Cancer research, Female, medicine.symptom, business, Research Article, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fbb488b6207d785aba1ad550e349b4Test
https://doaj.org/article/002b0c468859456f9262068df95cd277Test

7

Liver X Receptor Activation Impairs Neutrophil Functions and Aggravates Sepsis

المؤلفون: Walter Miguel Turato, José C. Alves-Filho, Maria Auxiliadora-Martins, Fernando Q. Cunha, Anibal Basile-Filho, Braulio H.F. Lima, Fabricio O. Souto, Silvia Cellone Trevelin, Guilherme Cesar Martelossi Cebinelli, Fernanda V. S. Castanheira

المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Neutrophils, Multiple Organ Failure, SEPSE, Inflammation, Punctures, Sepsis, Mice, 03 medical and health sciences, Peritoneal cavity, 0302 clinical medicine, medicine, Animals, Humans, Immunology and Allergy, Interleukin 8, Liver X receptor, Cecum, Ligation, Liver X Receptors, business.industry, Interleukin-8, Chemotaxis, Middle Aged, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Neutrophil Infiltration, Nuclear receptor, 030220 oncology & carcinogenesis, Bacteremia, Immunology, Female, lipids (amino acids, peptides, and proteins), medicine.symptom, business, ATP Binding Cassette Transporter 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf7be0511d2a99a8d0b5e363a6f52d8Test
https://doi.org/10.1093/infdis/jiz635Test

8

Cutaneous Epithelial to Mesenchymal Transition Activator ZEB1 Regulates Wound Angiogenesis and Closure in a Glycemic Status–Dependent Manner

المؤلفون: Saba Tabasum, Fidel Soto-Gonzalez, Sujit K Mohanty, Surya Gnyawali, Kanhaiya Singh, Mithun Sinha, Savita Khanna, Chandan K. Sen, Subendu Sarkar, Dolly K. Khona, Durba Pal, Sashwati Roy

المصدر: Diabetes

مصطلحات موضوعية: Adult, Blood Glucose, Keratinocytes, Male, 0301 basic medicine, Epithelial-Mesenchymal Transition, Angiogenesis, Endocrinology, Diabetes and Metabolism, Neovascularization, Physiologic, 030209 endocrinology & metabolism, Neovascularization, Adherens junction, Mice, 03 medical and health sciences, 0302 clinical medicine, Diabetes Mellitus, Internal Medicine, medicine, Animals, Humans, Epithelial–mesenchymal transition, Promoter Regions, Genetic, Cells, Cultured, Mice, Knockout, Wound Healing, integumentary system, Chemistry, Activator (genetics), Endothelial Cells, Zinc Finger E-box-Binding Homeobox 1, Genetics/Genomes/Proteomics/Metabolomics, Middle Aged, Cadherins, Up-Regulation, Endothelial stem cell, 030104 developmental biology, medicine.anatomical_structure, Cancer research, Female, medicine.symptom, Wound healing, Keratinocyte

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3bf93ee8b3e4cf1791b0ce2141a310Test
https://doi.org/10.2337/db19-0202Test

9

Induction of PDCD4 by albumin in proximal tubule epithelial cells potentiates proteinuria-induced dysfunctional autophagy by negatively targeting Atg5

المؤلفون: Dongmin Li, Fumeng Huang, Dong Liang, Xudong Yang, Xiaojuan Du, Lifang Tian, Jiajun Ren, Riaz Farooq, Shemin Lu, Ezra Kombo Osoro, Wenhua Zhu, Xi Lan, Muhammad Sadiq

المصدر: Biochemistry and cell biology = Biochimie et biologie cellulaire. 99(5)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbfb9b1b556c1df3c7ea6801eb311bfeTest
https://pubmed.ncbi.nlm.nih.gov/33831322Test

10

TANK-Binding Kinase 1 (TBK1) Serves as a Potential Target for Hepatocellular Carcinoma by Enhancing Tumor Immune Infiltration

المؤلفون: Yuchuan Jiang, Siliang Chen, Qiang Li, Junjie Liang, Weida Lin, Jinying Li, Zhilong Liu, Mingbo Wen, Mingrong Cao, Jian Hong

المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_treatment, Kaplan-Meier Estimate, Mice, 0302 clinical medicine, Tumor Microenvironment, Immunology and Allergy, Molecular Targeted Therapy, Original Research, Liver Neoplasms, Disease Management, Immunosuppression, hepatocellular carcinoma, Middle Aged, targeted therapy, Prognosis, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cytokines, Female, Disease Susceptibility, medicine.symptom, lcsh:Immunologic diseases. Allergy, Adult, TANK-binding kinase 1, Carcinoma, Hepatocellular, T cell, Immunology, Inflammation, Protein Serine-Threonine Kinases, 03 medical and health sciences, Immune system, Lymphocytes, Tumor-Infiltrating, medicine, Biomarkers, Tumor, Animals, Humans, Aged, Neoplasm Staging, Innate immune system, business.industry, immune infiltration, Gene Expression Profiling, Cancer, Computational Biology, medicine.disease, Xenograft Model Antitumor Assays, digestive system diseases, Disease Models, Animal, 030104 developmental biology, inflammation, Cancer research, Neoplasm Grading, business, lcsh:RC581-607, Transcriptome, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91083787433d9faed8f010fd7276d29fTest
http://europepmc.org/articles/PMC7930497Test

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