نتائج البحث

1

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

المؤلفون: Snuggs J, Shannon N. Tessier, Makarand V. Risbud, Irving M. Shapiro, R A B Bunning, C. L. Le Maitre

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Cell biology, Nucleus Pulposus, Molecular biology, Science, Primary Cell Culture, Aquaporin, Intervertebral Disc Degeneration, Article, Mice, 03 medical and health sciences, Rheumatic diseases, Chondrocytes, 0302 clinical medicine, Downregulation and upregulation, Enhancer binding, Gene expression, Animals, Humans, RNA, Small Interfering, Rats, Wistar, Mice, Knockout, Gene knockdown, Multidisciplinary, Aquaporin 1, Osmotic concentration, Chemistry, Osmolar Concentration, Middle Aged, Aquaporin 5, Rats, Mice, Inbred C57BL, Mechanisms of disease, 030104 developmental biology, Gene Expression Regulation, Tonicity, Medicine, Female, 030217 neurology & neurosurgery, Signal Transduction, Transcription Factors

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ee143d3c36cf2973f715cac5f156fecTest
https://doaj.orgTest/article/4138b596e4be471abac6b99852763239

2

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

المؤلفون: Aviv Regev, Eugene Drokhlyansky, Jozef Ukropec, Christian Wolfrum, Lucia Balazova, Gottfried Rudofsky, Wenfei Sun, Antonio Giordano, Lianggong Ding, Miroslav Balaz, Anna Sofie Husted, Patrik Stefanicka, Georgia Colleluori, Michal Slyper, Saverio Cinti, Zuzana Kovanicova, Thue W. Schwartz, Hua Dong

المصدر: Cell Metab

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d0e829fb1d588b5e9be24e980e95e0Test
https://doi.org/10.1038/s41586-020-2856-xTest

3

Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms

المؤلفون: Licio A. Velloso, Ariane Maria Zanesco, Daiane F. Engel, Alexandre Moura-Assis, Athanasios Papangelis, Carina Solon, Vanessa Cristina Dias Bóbbo, Trond Ulven, Guilherme Nogueira, Natália Ferreira Mendes

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Engel, D F, Bobbo, V C D, Solon, C S, Nogueira, G A, Moura-Assis, A, Mendes, N F, Zanesco, A M, Papangelis, A, Ulven, T & Velloso, L A 2020, ' Activation of GPR40 induces hypothalamic neurogenesis through p38-and BDNF-dependent mechanisms ', Scientific Reports, vol. 10, no. 1, 11047 . https://doi.org/10.1038/s41598-020-68110-2Test

مصطلحات موضوعية: Male, STRESS, Pyridines, lcsh:Medicine, Ligands, Adult neurogenesis, p38 Mitogen-Activated Protein Kinases, Receptors, G-Protein-Coupled, Mice, Neurotrophic factors, Receptor, lcsh:Science, Neurons, Multidisciplinary, biology, Chemistry, Neurogenesis, Imidazoles, Neurochemistry, Cell biology, OBESITY, POMC NEURONS, FATTY-ACIDS, STEM-CELLS, endocrine system, Cell Survival, p38 mitogen-activated protein kinases, Models, Neurological, Hypothalamus, Article, Cell Line, Methylamines, ADULT, DIETARY, Neurosphere, Free fatty acid receptor 1, Animals, Protein Kinase Inhibitors, Cell Proliferation, Cell growth, Interleukin-6, Brain-Derived Neurotrophic Factor, lcsh:R, PROTEIN-KINASE, Doublecortin, Mice, Inbred C57BL, MICE, biology.protein, lcsh:Q, Propionates, NEUROTROPHIC FACTOR

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66eba08413780d00163a93b89857e3cTest
http://link.springer.comTest/article/10.1038/s41598-020-68110-2

4

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

المؤلفون: Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein

المساهمون: UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Aging, Regulator, General Physics and Astronomy, mTORC1, Inbred C57BL, Muscle Development, Hydroxylation, chemistry.chemical_compound, Mice, 0302 clinical medicine, Amino Acids, lcsh:Science, Mice, Knockout, chemistry.chemical_classification, Multidisciplinary, Muscles, Amino acid, Cell biology, Mechanisms of disease, TOR signalling, Female, Leucine, Signal transduction, biological phenomena, cell phenomena, and immunity, Signal Transduction, Gene isoform, Adult, Knockout, Science, Procollagen-Proline Dioxygenase, Genetics and Molecular Biology, Mechanistic Target of Rapamycin Complex 1, Article, General Biochemistry, Genetics and Molecular Biology, Hypoxia-Inducible Factor-Proline Dioxygenases, 03 medical and health sciences, Clinical Research, Animals, Humans, Aged, Animal, Leucyl-tRNA synthetase, General Chemistry, Mice, Inbred C57BL, Oxygen, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, chemistry, Preclinical research, General Biochemistry, Disease Models, lcsh:Q, Leucine-tRNA Ligase, 030217 neurology & neurosurgery

وصف الملف: Electronic; application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed65d3a9ba21caa35226b725b5c4e464Test
https://doaj.orgTest/article/57ce964136154da49cd0e8f1b72242c1

5

High proliferation and delamination during skin epidermal stratification

المؤلفون: Ekaterina Soroka, Lisa Wirtz, Houda Khatif, Christian Kukat, Mareike Damen, Hisham Bazzi, Benjamin D. Simons

المساهمون: Wirtz, Lisa [0000-0001-9967-6729], Kukat, Christian [0000-0003-1508-0229], Simons, Benjamin D [0000-0002-3875-7071], Bazzi, Hisham [0000-0001-8388-4005], Apollo - University of Cambridge Repository, Simons, Benjamin D. [0000-0002-3875-7071]

المصدر: Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

مصطلحات موضوعية: 0301 basic medicine, Keratinocytes, Male, Cell division, 631/80/128/1965, General Physics and Astronomy, 96/31, Mice, 0302 clinical medicine, Skin Physiological Phenomena, Asymmetric cell division, 14/19, Child, Tissue homeostasis, Mice, Knockout, Multidisciplinary, Cell Differentiation, Middle Aged, Cell biology, medicine.anatomical_structure, Child, Preschool, 631/208/135, 64/60, Female, Keratinocyte, 82/1, Tumor Suppressor p53-Binding Protein 1, Hair Follicle, Ubiquitin Thiolesterase, Adult, Adolescent, Science, 631/80/641, Spindle Apparatus, Biology, Development, Models, Biological, Time-Lapse Imaging, General Biochemistry, Genetics and Molecular Biology, Article, 38/91, 03 medical and health sciences, Young Adult, medicine, Animals, Humans, 631/80/128/1383, Cilia, Mitosis, Cell Proliferation, Aged, Centrosome, Asymmetric Cell Division, General Chemistry, Hair follicle, Embryo, Mammalian, 631/136/2091, Spindle apparatus, 030104 developmental biology, Epidermis, Tumor Suppressor Protein p53, 030217 neurology & neurosurgery

وصف الملف: application/pdf; application/zip; text/xml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24baa0f4979d3f5d8ead1cc7145e9056Test
https://www.repository.cam.ac.uk/handle/1810/324614Test

6

HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F1

المؤلفون: Norikatsu Miyoshi, Masayuki Ohue, Shiki Fujino, Mamoru Uemura, Aya Ito, Tsunekazu Mizushima, Masayoshi Yasui, Chu Matsuda, Yuichiro Doki, Hidetoshi Eguchi

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

مصطلحات موضوعية: Male, Colorectal cancer, Apoptosis, Drug resistance, Mice, Hepatocyte Nuclear Factor 1-alpha, Induced pluripotent stem cell, Cancer, Aged, 80 and over, Glucose Transporter Type 1, Multidisciplinary, biology, Middle Aged, Gene Expression Regulation, Neoplastic, Chemotherapy, Adjuvant, Gene Knockdown Techniques, Disease Progression, Medicine, Female, Colorectal Neoplasms, Adult, endocrine system, Cell biology, Adolescent, Science, Primary Cell Culture, Article, Disease-Free Survival, Young Adult, Cell Line, Tumor, medicine, Animals, Humans, Aged, Cell Proliferation, Cell growth, business.industry, medicine.disease, Xenograft Model Antitumor Assays, Multiple drug resistance, HIF1A, Drug Resistance, Neoplasm, Cancer research, biology.protein, GLUT1, business, Octamer Transcription Factor-3, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbba406b77752877f49b0f5b5919ed40Test
http://europepmc.org/articles/PMC8121855Test

7

Identification of candidate PAX2-regulated genes implicated in human kidney development

المؤلفون: Shigeki Hirabayashi, Keisuke Sako, Kengo Furuichi, Yasunori Iwata, Atsushi Tajima, Masahito Yoshihara, Philip M. Murphy, Tadashi Toyama, Keisuke Okita, Shinji Kitajima, Kazuyoshi Hosomichi, Takashi Wada, Norihiko Sakai, Yuta Yamamura, Yasuhiro Murakawa, Shuichi Kaneko, Kenji Osafune

المصدر: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)

مصطلحات موضوعية: 0301 basic medicine, Nephrology, Male, Integrins, Kidney development, Stem cells, Kidney, urologic and male genital diseases, 0302 clinical medicine, Mice, Inbred NOD, Renal Insufficiency, Induced pluripotent stem cell, Multidisciplinary, Pre-B-Cell Leukemia Transcription Factor 1, Gene Expression Regulation, Developmental, Middle Aged, Cell biology, Coloboma, medicine.anatomical_structure, Medicine, Female, Stem cell, Adult, medicine.medical_specialty, Science, Induced Pluripotent Stem Cells, Biology, Article, 03 medical and health sciences, Internal medicine, Developmental biology, medicine, Genetics, Animals, Humans, Cell Lineage, Enhancer, urogenital system, PAX2 Transcription Factor, Promoter, Nephrons, Cap analysis gene expression, Mice, Inbred C57BL, 030104 developmental biology, sense organs, Cell Adhesion Molecules, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ac54df056d25add61c4aab899c16a67Test
http://europepmc.org/articles/PMC8079710Test

8

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

المؤلفون: Hiroshi Asahara, Yoshiaki Ito, Tokio Matsuzaki, Kohei Miyata, Tempei Sato, Martin Lotz, Ryo Nakamichi, Merissa Olmer, Eiji Sugiyama, Masafumi Inui, Sho Mokuda

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cartilage, Articular, CRISPR-Cas9 genome editing, Knee Joint, Ubiquitylation, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, 02 engineering and technology, Osteoarthritis, Menisci, Tibial, Mice, Ubiquitin, lcsh:Science, Aged, 80 and over, Mice, Knockout, Multidisciplinary, biology, Cartilage homeostasis, Chemistry, Middle Aged, 021001 nanoscience & nanotechnology, musculoskeletal system, Ubiquitin ligase, Cell biology, RUNX2, medicine.anatomical_structure, miRNAs, 0210 nano-technology, Signal Transduction, Adult, musculoskeletal diseases, Ubiquitin-Protein Ligases, Science, WWP2, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Animals, Humans, RNA, Messenger, Aged, Cartilage, Skull, Ubiquitination, General Chemistry, X-Ray Microtomography, medicine.disease, Arthritis, Experimental, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:Q, ADAMTS5 Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c9bffffe46cfae2df3f937bdfb3f0Test
http://link.springer.comTest/article/10.1038/s41467-019-10177-1

9

Morroniside regulates hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway

المؤلفون: Zhong-Fa Lu, Lijuan Zhou, Jing Jing, Lijuan Yu, Han Wang, Xian-Jie Wu

المصدر: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Adolescent, Lymphoid Enhancer-Binding Factor 1, Cell, lcsh:Medicine, Outer root sheath, Article, 03 medical and health sciences, Mice, Young Adult, Cornus, Downregulation and upregulation, Proto-Oncogene Proteins, medicine, Loose Anagen Hair Syndrome, Animals, Humans, Glycosides, lcsh:Science, Wnt Signaling Pathway, Cells, Cultured, beta Catenin, Cell Proliferation, Multidisciplinary, integumentary system, Chemistry, lcsh:R, Wnt signaling pathway, Alopecia, Middle Aged, medicine.disease, In vitro, Cell biology, Mice, Inbred C57BL, Wnt Proteins, 030104 developmental biology, medicine.anatomical_structure, Hair loss, DKK1, Intercellular Signaling Peptides and Proteins, Female, lcsh:Q, Signal transduction, Hair Follicle, Hair

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc56d7aadcf4f24e2d2ceda364521b79Test
http://link.springer.comTest/article/10.1038/s41598-018-32138-2

10

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

المؤلفون: Jae-Hyuck Shim, Julia F. Charles, Matthew B. Greenblatt, Yeon Suk Yang, Paul B. Yu, Takeshi Takarada, Xianpeng Ge, Hyunho Chun, Wei Gu, Jung-Min Kim, Minkyung Song, Teresa Dinter, Na Li, Odile Filhol-Cochet, Seoyeon Bok, Kwang Hwan Park, Ning Kon, Ren Xu, Brigitte Boldyreff

المساهمون: University of Massachusetts Medical School [Worcester] (UMASS), University of Massachusetts System (UMASS), Yonsei University College of Medicine [Séoul, Corée du Sud], Xiamen University, Sungkyunkwan University [Suwon] (SKKU), Korea Advanced Institute of Science and Technology (KAIST), Weill Medical College of Cornell University [New York], Harvard Medical School [Boston] (HMS), Biologie du Cancer et de l'Infection (BCI ), Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), KinaseDetect ApS [Krusa, Danemark], Columbia University College of Physicians and Surgeons, Okayama University Graduate School of Medicine [Okayama, Japon], This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2014R1A6A3A03055719, J.M.K.). M.B.G. holds a Career Award for Medical Scientists from the Burroughs Wellcome Fund, a Basil O’Connor Award from the March of Dimes and is supported by an NIH Director’s Early Independence Award (1DP5OD021351), and a Pershing Square Sohn Cancer Research Prize for Young Investigators. J.H.S holds support from NIAMS of the NIH under R01AR068983, R21AR072836, and R21AR073331, an UMCCTS pilot project program award., Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Bodescot, Myriam

المصدر: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2289. ⟨10.1038/s41467-020-16038-6⟩
Nature Communications, 2020, 11 (1), pp.2289. ⟨10.1038/s41467-020-16038-6⟩
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, Cellular differentiation, Regulator, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, Haploinsufficiency, Ubiquitin-Specific Peptidase 7, 0302 clinical medicine, Osteogenesis, Phosphorylation, lcsh:Science, Casein Kinase II, [SDV.MHEP.RSOA] Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, Multidisciplinary, Chemistry, Protein Stability, musculoskeletal, neural, and ocular physiology, Bone development, Osteoblast, Cell Differentiation, [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], Middle Aged, Cell biology, Hindlimb, RUNX2, medicine.anatomical_structure, [SDV.MHEP.RSOA]Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system, 030220 oncology & carcinogenesis, embryonic structures, Female, Stem cell, Casein kinase 2, Cleidocranial Dysplasia, Deubiquitination, Adult, musculoskeletal diseases, endocrine system, Science, Trauma, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, stomatognathic system, medicine, Animals, Humans, RNA, Messenger, Bone, Aged, Osteoblasts, Ossification, Heterotopic, fungi, General Chemistry, Mice, Inbred C57BL, 030104 developmental biology, [SDV.BBM.MN] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular Networks [q-bio.MN], lcsh:Q, Gene Deletion

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00319c1a7f6e3ba18b9a9d0433f9d156Test
https://www.hal.inserm.fr/inserm-02651683/documentTest

تنقيح النتائج