المؤلفون: Im, Jin S, Abraham, Susan C, Saliba, Rima M, Rondon, Gabriela, Ross, William A, Rashid, Asif, Shpall, Elizabeth J, Popat, Uday, Qazilbash, Muzaffar H, Hosing, Chitra, Oran, Betul, Shah, Nina, Tewari, Priti, Nieto, Yago, Kebriaei, Partow, Champlin, Richard E, Alousi, Amin M

المصدر: The American Journal of Surgical Pathology. 41(11)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Cancer, Transplantation, Digestive Diseases, Rare Diseases, Clinical Research, Good Health and Well Being, Adolescent, Adult, Aged, Biopsy, Bone Marrow Transplantation, Chi-Square Distribution, Child, Child, Preschool, Cord Blood Stem Cell Transplantation, Endoscopy, Gastrointestinal, Female, Gastrointestinal Diseases, Gastrointestinal Tract, Graft vs Host Disease, Hematologic Neoplasms, Humans, Kaplan-Meier Estimate, Male, Middle Aged, Multivariate Analysis, Peripheral Blood Stem Cell Transplantation, Predictive Value of Tests, Prognosis, Retrospective Studies, Risk Factors, Severity of Illness Index, Young Adult, prognostic value, histologic grade 1, gastrointestinal graft versus host disease, Pathology, Clinical sciences

الوصف: Histologic confirmation is considered a standard practice to diagnose gastrointestinal graft versus host disease (GI GVHD) and is often used in making treatment decisions. A histologic grade is often determined in cases that are diagnosed with GI GVHD. Although extensive crypt loss (histologic grade 4) is associated with high nonrelapse mortality (NRM), the prognostic value for the more common grade 1 is poorly understood. As clinical decisions are made on the degree of histologic evidence, it is important to establish its prognostic significance. Therefore, we evaluated 309 patients who underwent endoscopic biopsy for suspected GI GVHD within 6 months posttransplant between 2009 and 2012. The presence of histologic grade 1 was associated with increased NRM (hazard ratio=2.7, P=0.02) when compared with one of negative biopsy in patients with lower but not isolated upper GI GVHD. Multivariate competing-risk regression analysis confirmed the independent impact of histologic grade 1 in patients with early clinical stages of lower GI GVHD (stage 0 to 2) (hazard ratio=2.7, P=0.044). When compared with advanced histologic grades, histologic grade 1 did not lessen the adverse outcome for patients with advanced lower GI GVHD (stage 3 to 4) (cumulative incidence NRM of 84%). In conclusion, the presence of histologic grade 1 is associated with increased NRM in patients presenting with lower GI GVHD (stages 0 to 2) and is sufficient evidence for decision to initiate therapy. At the same time, histologic grade 1 does not lessen the markedly adverse impact of advanced lower GI GVHD (stage 3 to 4) and is not synonymous with "mild" GVHD.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/13v2n7d2Test

المؤلفون: Kyoichi Kaira, Ou Yamaguchi, Hiroyuki Nitanda, Hirozo Sakaguchi, Akitoshi Yanagihara, Hiroshi Kagamu, Tomonori Kawasaki, Tetsuya Umesaki, Kunihiko Kobayashi, Atsuto Mouri, Hisao Imai, Kosuke Hashimoto, Ryo Taguchi, Ichiei Kuji, Masanori Yasuda

المصدر: Cancer Medicine, Vol 10, Iss 18, Pp 6317-6326 (2021)
Cancer Medicine

مصطلحات موضوعية: Male, Cancer Research, Pathology, Biopsy, B7-H1 Antigen, Warburg Effect, Oncologic, Neoplasms, Glandular and Epithelial, Thymic carcinoma, Research Articles, RC254-282, Aged, 80 and over, Glucose Transporter Type 1, medicine.diagnostic_test, biology, HIF‐1α, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Thymectomy, Oncology, Positron emission tomography, thymic epithelial tumor, immunohistochemistry, Immunohistochemistry, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Thymoma, Thymus Gland, Fluorodeoxyglucose F18, PD-L1, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Performance status, business.industry, Clinical Cancer Research, Thymus Neoplasms, Hypoxia (medical), medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Programmed Cell Death 1 Ligand 2 Protein, PD‐L1, Positron-Emission Tomography, PD‐L2, biology.protein, Tumor Hypoxia, GLUT1, 18F‐FDG uptake, business

الوصف: Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint. Conclusion 18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells.
High expression of PD‐L1/PD‐L2 was closely associated with high accumulation of 18F‐FDG. Angiogenetic markers were linked to the expression of PD‐L1/PD‐L2. PD‐L1 and PD‐L2 exhibited a close relationship with upregulation of tumor glucose metabolism and hypoxia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15261651d62bd866f1c6478c8c6c3373Test
https://doaj.org/article/a8142366e6a1438799401c111ae0c803Test

المؤلفون: Taishi Takahara, Kazuyuki Shimada, Shigeo Nakamura, Akira Satou, Seiichi Kato, Tasuku Kawano, Mayuko Mori, Masato Nakaguro, Yuta Tsuyuki, Yuka Suzuki, Ayako Sakakibara

المصدر: American Journal of Surgical Pathology. 45:1606-1615

مصطلحات موضوعية: Adult, Male, Epstein-Barr Virus Infections, Herpesvirus 4, Human, Pathology, medicine.medical_specialty, Time Factors, Adrenal Gland Neoplasms, Tumor cells, Disease, B7-H1 Antigen, Pathology and Forensic Medicine, Programmed cell death ligand 1, Immune system, Japan, Risk Factors, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, medicine, Humans, Immunodeficiency, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Adrenalectomy, Middle Aged, medicine.disease, Progression-Free Survival, Lymphoma, RNA, Viral, Female, Surgery, Pd l1 expression, Lymphoma, Large B-Cell, Diffuse, Anatomy, Rituximab, business, Diffuse large B-cell lymphoma

الوصف: Primary adrenal diffuse large B-cell lymphoma (PA-DLBCL) is rare. We investigate 23 Japanese patients with PA-DLBCL to understand the clinicopathologic features and biological behavior of this disease. The 17 males and 6 females had a median age of 74 years (range: 40 to 86 y). Tumor cells harbored Epstein-Barr virus-encoded small RNA (EBER) in 9 (39%) samples, including samples from the 2 patients with methotrexate-associated B-cell lymphoproliferative disorder. Programmed cell death ligand 1 (PD-L1) expression was detected in tumor cells of 6 (26%) samples, including 1 EBER+ and 5 EBER- samples. Four (17%) patients exhibited an intravascular proliferating pattern, and all 4 patient samples showed positive staining for PD-L1 in tumor cells. Among those patients, 3 showed intravascular proliferating pattern accompanied by a diffuse extravascular proliferation of tumor cells, and 1 patient was diagnosed with intravascular large B-cell lymphoma. We divided the 23 patients into 3 groups: EBER+ (n=9, 39%), EBER-PD-L1+ (n=5, 22%), and EBER-PD-L1- (n=9, 39%). A comparison of the outcomes among the 3 groups showed significant differences in overall survival (P=0.034). The EBER+ group had the worst prognosis, and the EBER-PD-L1- group had the best prognosis. We also compared the outcomes among the 3 groups that received rituximab-containing chemotherapies. Both the overall survival and progression-free survival were significantly different among these groups (P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0686eafac1652ca09a4707e44d45e0eTest
https://doi.org/10.1097/pas.0000000000001809Test

المؤلفون: Ming-yan Deng, Yan Ren, Tao Chen, Liling Deng, Haoming Tian, Yuanmei Li, Huan Xu, Dan Mo

المصدر: BioMed Research International
BioMed Research International, Vol 2020 (2020)

مصطلحات موضوعية: Adult, Male, China, Pathology, medicine.medical_specialty, Article Subject, Galectin 3, Galectins, Adrenal Gland Neoplasms, 030209 endocrinology & metabolism, Kaplan-Meier Estimate, Pheochromocytoma, Snail, General Biochemistry, Genetics and Molecular Biology, Receptor, IGF Type 1, Diagnosis, Differential, Paraganglioma, 03 medical and health sciences, 0302 clinical medicine, biology.animal, Biomarkers, Tumor, Humans, Medicine, Survival analysis, Aged, Retrospective Studies, Insulin-like growth factor 1 receptor, General Immunology and Microbiology, biology, business.industry, Retrospective cohort study, Blood Proteins, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, body regions, Galectin-3, 030220 oncology & carcinogenesis, Female, Snail Family Transcription Factors, Differential diagnosis, business, Software, Research Article

الوصف: Objective. The aim of this study was to investigate the expression of Snail, galectin-3, and IGF1R in benign and malignant pheochromocytoma and paraganglioma (PPGL) and explore their role in the diagnosis of malignant PPGL. Methods. We retrospectively collected and analyzed surgical tumor tissue from 226 patients initially diagnosed with PPGL who underwent surgery from Jan. 2009 to Jan. 2016 at West China Hospital, Sichuan University. We observed and quantified the expression of Snail, galectin-3, and IGF1R in paraffin-embedded samples by immunohistochemical staining. Results. The significant difference in survival time among the three groups (benign PHEO, benign PGL, and potentially malignant PPGL) was compared by Kaplan-Meier survival analysis. The positive staining of Snail, galectin-3, and IGF1R in the benign PHEO group was significantly lower than that in the other three groups (P<0.001). The Kaplan-Meier survival plots indicated that the survival time of the patients with intense positive staining was significantly lower than that of the patients with weak positive staining. Conclusion. The intense expression of Snail, galectin-3, and IGF1R may be valuable indicators for the diagnosis of malignant PPGL.

وصف الملف: text/xhtml

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6665e0fde86f52dc711d317c0e9184bTest
https://doi.org/10.1155/2020/4150735Test

المؤلفون: Daisuke Murakami, Takashi Nakagawa, Yusuke Miyamoto, Tetsuya Koyama, Hirofumi Omori, Kaname Miyashita, Motohiro Sawatsubashi

المصدر: Journal of Clinical and Experimental Hematopathology : JCEH

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, Adolescent, medicine.medical_treatment, diffuse large B-cell lymphoma, chemotherapy, Disease-Free Survival, Malignant lymphoma, 03 medical and health sciences, 0302 clinical medicine, Japan, immune system diseases, hemic and lymphatic diseases, Medicine, Humans, human T-cell leukemia virus type 1, Aged, Retrospective Studies, Aged, 80 and over, Chemotherapy, Human T-lymphotropic virus 1, Disease entity, business.industry, Endemic area, General Medicine, Sinonasal Tract, Middle Aged, medicine.disease, Lymphoma, primary sinonasal lymphoma, Survival Rate, Leukemia, 030104 developmental biology, 030220 oncology & carcinogenesis, Original Article, Female, Lymphoma, Large B-Cell, Diffuse, business, Diffuse large B-cell lymphoma, Paranasal Sinus Neoplasms

الوصف: The present study investigated histological subtypes of lymphoma in patients newly diagnosed with malignant lymphoma in the human T-cell leukemia virus type 1 (HTLV-1) endemic area of Japan, and further analyzed the clinicopathological features and clinical outcomes of patients with primary sinonasal lymphoma. We retrospectively examined 151 patients aged 18-90 years in Fukuoka, Japan. Subtypes of lymphoma were determined according to the WHO classification. Among the 151 patients, 104 were diagnosed with malignant lymphoma, including 96 at the time of initial diagnosis. Ninety-two of the 96 lymphomas (96%) were non-Hodgkin lymphoma. Mature B-cell neoplasms comprised 78% (n = 75). Primary lymphoma of the sinonasal cavity was found in six patients (6%). The histological subtype of sinonasal lymphoma was diffuse large B-cell lymphoma (DLBCL) in all six tumors. Furthermore, overall survival was significantly different among three distinct DLBCL patient groups, including primary sinonasal lymphoma patients (p = 0.0016; 3-year overall survival: sinonasal DLBCL group, 53%; DLBCL of the CNS group, 0%; other DLBCL group, 83%). Our study suggests that primary DLBCL of the sinonasal tract is a distinct disease entity of DLBCL.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f36246b63fda5b826c24f6778b017439Test
http://europepmc.org/articles/PMC6798144Test

المؤلفون: Christopher A. Moskaluk, Mansoor Mubeen, Martha Thomas, Brett Kurpiel, Anne M. Mills, Kari L. Ring, Susan C. Modesitt

المصدر: International Journal of Gynecological Pathology. 41:1-11

مصطلحات موضوعية: Adult, Oncology, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Pathology, DNA Mismatch Repair, Germline, Pathology and Forensic Medicine, Germline mutation, Internal medicine, PMS2, Humans, Medicine, Promoter Regions, Genetic, neoplasms, Germ-Line Mutation, Aged, Mismatch Repair Endonuclease PMS2, Retrospective Studies, Genetic testing, Aged, 80 and over, POLD1, medicine.diagnostic_test, business.industry, nutritional and metabolic diseases, Obstetrics and Gynecology, DNA Methylation, Middle Aged, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, Immunohistochemistry, digestive system diseases, Lynch syndrome, Endometrial Neoplasms, MSH6, MSH2, Female, MutL Protein Homolog 1, business

الوصف: MLH1/PMS2 loss due to epigenetic hypermethylation of the MLH1 promoter is the most common cause of mismatch repair deficiency in endometrial carcinoma, and typically provides reassurance against an associated germline mutation. To further characterize the genetic features of MLH1/PMS2-deficient endometrial cancers, the departmental database was searched for cases with dual MLH1/PMS2 loss and retained MSH2/6 expression which underwent MLH1 hypermethylation testing. Genetic testing results were obtained when available. One hundred seventeen endometrial cancers met inclusion criteria: 100 (85%) were MLH1-hypermethylated, 3 (3%) were low-level/borderline, 7 (6%) were nonmethylated, and 7 (6%) were insufficient for testing. Sixteen cases (12 MLH1-hypermethylated, 3 nonmethylated, and 1 insufficient for testing) underwent germline testing, 6 of which (37.5%) demonstrated germline variants of unknown significance (VUS) (MSH6, PMS2, POLD1, BRIP1, RAD51D, CHEK2) but no known deleterious mutations. Notably, however, the patients harboring the MSH6 and PMS2 germline VUS had clinical features concerning for Lynch syndrome. One nonmethylated, germline-normal case underwent somatic tumor testing, and demonstrated a somatic MLH1 mutation. In summary, MLH1-hypermethylation accounts for the vast majority of MLH1/PMS2-deficient cancers in a universally screened population, although MLH1 somatic and germline mutations can occur. Occasionally, patients with MLH1-hypermethlated tumors also bear germline VUS in other mismatch repair genes as well as genes implicated in other hereditary cancer syndromes, but their clinical relevance is unclear. Family and personal cancer histories must always be evaluated to determine the need for germline testing in women with loss of MLH1/PMS2, even in the setting of hypermethylation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa9f9606604c2579455cf8d7692d4baTest
https://doi.org/10.1097/pgp.0000000000000767Test

المؤلفون: Min Han, Ted Farzaneh, Whayoung Lee, Behdokht Nowroozizadeh

المصدر: Acta Cytologica. 65:250-256

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Histology, Adolescent, Lymphoid Enhancer-Binding Factor 1, Neuroendocrine tumors, Pathology and Forensic Medicine, Diagnosis, Differential, Young Adult, Predictive Value of Tests, Cytology, Biopsy, Biomarkers, Tumor, medicine, Humans, Aged, Retrospective Studies, biology, medicine.diagnostic_test, business.industry, Reproducibility of Results, Chromogranin A, General Medicine, Gold standard (test), Middle Aged, medicine.disease, Immunohistochemistry, Carcinoma, Papillary, Pancreatic Neoplasms, medicine.anatomical_structure, biology.protein, Synaptophysin, Female, Pancreas, business

الوصف: Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare neoplasm. Diagnosis of SPN requires an integrated approach with aid of radiology, biopsy, cytology, and immunohistochemical stains. Although morphological features in combination with nuclear positivity of β-catenin IHC have been the gold standard of SPN diagnosis, but overlapping morphology and immunohistochemical findings with other entities in differential diagnoses such as pancreatic neuroendocrine tumors and pancreatic ductal adenocarcinoma make the diagnosis of SPN difficult particularly in limited cytology specimens. Lymphoid enhancer-binding factor 1 (LEF1), a key player in the Wnt signaling pathway, has shown promising diagnostic utility in SPN in recent literatures. Methods: In this retrospective study, we evaluated the diagnostic utility of LEF1 IHC in SPN in cytology specimens. LEF1 IHC was performed and compared with β-catenin, synaptophysin, and chromogranin immunostains in 13 SPN and 23 pancreatic neuroendocrine tumors (PanNETs) cytology cases with retrievable cell blocks. Results: LEF1 was positive in 13 of 13 (100%) SPNs and was negative in all PanNETs (0%). Conclusion: LEF1 shows 100% sensitivity and specificity in cytology specimens for SPN and can be valuable immuno­stain in the diagnosis of SPN in cytology cell blocks.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e260d7fc743fce9027091641a4894aa1Test
https://doi.org/10.1159/000515446Test

المؤلفون: Masao Akagi, Kazuhiko Hashimoto, Tomohiko Ito, Shunji Nishimura

المصدر: European Journal of Histochemistry, Vol 65, Iss 3 (2021)
European Journal of Histochemistry : EJH

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Pathology, medicine.medical_specialty, programmed death-ligand 1, Histology, QH301-705.5, Fibrosarcoma, Programmed Cell Death 1 Receptor, Biophysics, Malignant peripheral nerve sheath tumor, PD-1/PD-L1, B7-H1 Antigen, Disease-Free Survival, Article, 03 medical and health sciences, Immune checkpoint inhibitors, 0302 clinical medicine, Immune system, Antigen, PD-L1, Biopsy, medicine, Humans, Biology (General), Aged, Retrospective Studies, programmed death-1, Aged, 80 and over, medicine.diagnostic_test, biology, business.industry, Soft tissue sarcoma, Cell Biology, Middle Aged, medicine.disease, Prognosis, Immune checkpoint, Progression-Free Survival, 030104 developmental biology, Neurofibrosarcoma, 030220 oncology & carcinogenesis, soft tissue sarcoma, biology.protein, Female, business, Immunostaining

الوصف: Inhibitors of the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) immune checkpoint system are used for treating various malignancies. However, evidence on their use in soft tissue sarcomas (STS) is limited. This study aimed to retrospectively investigate the relationship between the expression of PD-1/PD-L1 and related antigens in STS, and their association with clinical characteristics. Immunostaining for CD4, CD8, PD-1, PD-L1, IL-2, and IFN-γ was performed using pathological specimens harvested at the time of biopsy from 10 patients with undifferentiated pleomorphic sarcoma (UPS), nine with myxofibrosarcoma (MFS), and three with malignant peripheral nerve sheath tumor (MPNST) who were treated at our hospital. Subsequently, the positive immunostaining cell rates were calculated. We also examined the correlation between each immune positive cell rate and age, tissue grade, size, and maximum standardized uptake (SUV-max) values. The 3-year event-free survival (EFS) and overall survival (OS) rates were compared between the positive and negative groups (positive rate >10%; negative

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa03fe587e1fb2b7aebc88a98ab0ab79Test
https://www.ejh.it/index.php/ejh/article/view/3203Test

المؤلفون: Ayesha U. Khan, Pedram Gerami, Elsy V. Compres, Daniel Kim, Klaus J. Busam, Joel C. Sunshine, Bin Zhang

المصدر: Am J Dermatopathol

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Skin Neoplasms, Adolescent, Databases, Factual, DNA Mutational Analysis, MAP Kinase Kinase 1, Dermatology, Article, Pathology and Forensic Medicine, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Nevus, Epithelioid and Spindle Cell, MAP2K1, medicine, Humans, Nevus, Genetic Predisposition to Disease, Clinical care, Child, Frameshift Mutation, Aged, Retrospective Studies, business.industry, Melanoma, High-Throughput Nucleotide Sequencing, General Medicine, Middle Aged, medicine.disease, Deep penetrating melanocytic nevus, Tumor recurrence, Phenotype, Treatment Outcome, Child, Preschool, Female, Melanocytoma, Melanin pigment, business

الوصف: With the advent of better molecular characterization of Spitz melanocytic neoplasms, there has been increasing effort to better understand and describe the relationships between specific driver fusion and/or mutations with the clinical and histomorphological characteristics of the lesions. Structural rearrangements in mitogen activated protein kinase genes have recently been noted to be important in Spitz neoplasms. Only very few reports, however, have described in detail melanocytic tumors with in frame deletions in MAP2K1. Cases in the literature with this aberration have been described as having a diagnosis of Spitz, deep penetrating nevi, or pigmented epithelioid melanocytoma. In this study, we describe a cohort of 6 cases with MAP2K1 activating in frame deletions. The morphologic spectrum of the cases was broad. Common features of these cases include Spitzoid cytomorphology (5/6) cases, prominent melanin pigmentation (4/6) cases, and deep penetrating nevi-like plexiform architecture (3/6) cases. The diagnoses at the time of clinical care of these cases included nevus of Reed (1/6), desmoplastic Spitz tumor (1/6), BAPoma (1/6), deep penetrating melanocytic nevus (2/6), and melanoma (1/6). Clinical follow-up was available in 3 of the 6 cases. None of the patients had a tumor recurrence. This builds on the growing literature to help expand the spectrum of changes associated with Spitzoid melanocytic neoplasms.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b00619ee8aa9f7f4d59243b1a17f22Test
https://doi.org/10.1097/dad.0000000000001795Test

المؤلفون: Hsiang-Ling Ho, Yen-Yu Lin, Jen-Fan Hang, Teh Ying Chou, Li-Ya Lin, Chia-Hung Lin

المصدر: Cancer Cytopathology. 129:148-155

مصطلحات موضوعية: Adult, Male, Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Thyroid Nuclear Factor 1, 030209 endocrinology & metabolism, Adenocarcinoma, Stain, B7-H1 Antigen, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Thyroid, Middle Aged, medicine.disease, Immunohistochemistry, Immune checkpoint, Staining, medicine.anatomical_structure, Oncology, Cytopathology, 030220 oncology & carcinogenesis, Female, Histopathology, business

الوصف: BACKGROUND Immune checkpoint inhibitor therapy has revolutionized lung adenocarcinoma therapy. Treatment with antibodies against the immune checkpoint molecules programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) can induce a durable response in a subset of patients. Immunohistochemistry characterization of tumor PD-L1 expression using either a histopathology specimen or a cytopathology specimen has been shown to correlate with treatment response. However, the current practice relies on pathologists' visual estimation of tumor PD-L1 staining, which can be variable in certain conditions. Highlighting tumor cells via double immunostaining with PD-L1 and thyroid transcription factor-1 (TTF-1) may improve estimation accuracy. METHODS We performed PD-L1 single staining and PD-L1/TTF-1 double staining in 42 pairs of cytopathology and histopathology specimens from lung adenocarcinoma patients. An experienced pathologist visually estimated PD-L1 expression in each case and placed tumor PD-L1 expression into 1 of 3 categories

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd2d6676569dae5796c43dbde371c5cTest
https://doi.org/10.1002/cncy.22359Test