نتائج البحث

1

Safety and Glycemic Outcomes During the MiniMed™ Advanced Hybrid Closed-Loop System Pivotal Trial in Adolescents and Adults with Type 1 Diabetes

المصدر: Diabetes Technology & Therapeutics. 24:178-189

الوصف: Introduction: This trial assessed safety and effectiveness of an advanced hybrid closed-loop (AHCL) system with automated basal (Auto Basal) and automated bolus correction (Auto Correction) in adol...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0139095a17c711398f86d1cf4cb966Test
https://doi.org/10.1089/dia.2021.0319Test

2

Anti-AT1R autoantibodies and prediction of the severity of Covid-19

المؤلفون: Carla Cervelli, Franco Marinangeli, Anna Cecilia Carucci, Alessandro Grimaldi, Vincenza Cofini, Chiara Angeletti, Stefano Necozione, Franco Papola, Veronica Biancofiore, Alessia Rosciano

المصدر: Human Immunology

مصطلحات موضوعية: Adult, Male, Angiotensin II, AT1R autoantibodies, SARS-CoV-2 infection, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Short Communication, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Immunology, Stimulation, Autoantigens, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, Gastroenterology, Receptor, Angiotensin, Type 1, Internal medicine, medicine, Humans, Immunology and Allergy, Respiratory system, AngII, Angiotensin II, Aged, Autoantibodies, Retrospective Studies, Aged, 80 and over, Angiotensin II receptor type 1, SARS-CoV-2, business.industry, Autoantibody, COVID-19, General Medicine, Middle Aged, medicine.disease, ACE-2, Angiotensin Converting Enzyme, Hospitalization, Italy, Female, business, Cytokine storm, AT1Rab, autoantibodies direct vs Angiotensin II Receptor1

الوصف: The stimulation of AT1R (Angiotensin II Receptor Type 1) by Angiotensin II has, in addition to the effects on the renin-angiotensin system, also pro-inflammatory effects through stimulation of ADAM17 and subsequent production of INF-gamma and Interleukin-6. This pro-inflammatory action stimulate the cytokine storm that characterizes the most severe forms of SARS-CoV-2 infection. We studied the effect of AT1Rab on the AT1R on 74 subjects with SARS-CoV-2 infection with respiratory symptoms requiring hospitalization. We divided the patients into 2 groups: 34 with moderate and 40 with severe symptoms that required ICU admission. Hospitalized subjects showed a 50% reduction in the frequency of AT1Rab compared to healthy reference population. Of the ICU patients, 33/40 (82.5%) were AT1Rab negative and 16/33 of them (48.5%) died. All 7 patients positive for AT1Rab survived. These preliminary data seem to indicate a protective role played by AT1R autoantibodies on inflammatory activation in SARS-CoV-2 infection pathology.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072859fa313f38d2ce140b2f398e7d77Test
https://doi.org/10.1016/j.humimm.2021.10.006Test

3

PD‐L1 expression is associated with the spontaneous regression of patients with methotrexate‐associated lymphoproliferative disorders

المؤلفون: Tadashi Yoshino, Naoya Nakamura, Misa Sakamoto, Tomoka Ikeda, Yuria Egusa, Yoshito Nishimura, Yasuharu Sato, Azusa Fujita, Misato Doi, Noriko Iwaki, Asami Nishikori, Midori Filiz Nishimura, Yuka Gion

المصدر: Cancer Medicine, Vol 11, Iss 2, Pp 417-432 (2022)
Cancer Medicine

مصطلحات موضوعية: Male, rheumatoid arthritis, Cancer Research, medicine.medical_treatment, Remission, Spontaneous, Spontaneous remission, Kaplan-Meier Estimate, Gastroenterology, B7-H1 Antigen, Arthritis, Rheumatoid, Pathogenesis, programmed cell death‐ligand 1, rheumatoid arthritis, immune system diseases, hemic and lymphatic diseases, heterocyclic compounds, skin and connective tissue diseases, Research Articles, classic Hodgkin lymphoma, RC254-282, Aged, 80 and over, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Hodgkin Disease, Oncology, Antirheumatic Agents, Female, Lymphoma, Large B-Cell, Diffuse, Research Article, medicine.drug, Adult, musculoskeletal diseases, medicine.medical_specialty, methotrexate‐associated lymphoproliferative disorder, diffuse large B-cell lymphoma, Lymphoproliferative disorders, programmed cell death-ligand 1, Internal medicine, medicine, Humans, methotrexate-associated lymphoproliferative disorder, Radiology, Nuclear Medicine and imaging, Aged, Chemotherapy, business.industry, diffuse large B‐cell lymphoma, Clinical Cancer Research, medicine.disease, Lymphoma, Discontinuation, Methotrexate, business, Diffuse large B-cell lymphoma

الوصف: Background Most patients with methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) show diffuse large B‐cell lymphoma (DLBCL) or classic Hodgkin lymphoma (CHL) types. Patients with MTX‐LPD often have spontaneous remission after MTX discontinuation, but chemotherapeutic intervention is frequently required in patients with CHL‐type MTX‐LPD. In this study, we examined whether programmed cell death‐ligand 1 (PD‐L1) expression levels were associated with the prognosis of MTX‐LPD after MTX discontinuation. Methods A total of 72 Japanese patients diagnosed with MTX‐LPD were clinicopathologically analyzed, and immunohistochemical staining of PD‐L1 was performed in 20 DLBCL‐type and 24 CHL‐type MTX‐LPD cases to compare with the clinical course. Results PD‐L1 was expressed in 5.0% (1/20) of patients with DLBCL‐type MTX‐LPD, whereas it was expressed in 66.7% (16/24) of the patients with CHL‐type MTX‐LPD in more than 51% of tumor cells. Most CHL‐type MTX‐LPD patients with high PD‐L1 expression required chemotherapy owing to exacerbations or relapses after MTX discontinuation. However, no significant differences in clinicopathologic findings at diagnosis were observed between PD‐L1 high‐ and low‐expression CHL‐type MTX‐LPD. Conclusion PD‐L1 expression was significantly higher in patients with CHL‐type than DLBCL‐type MTX‐LPD, suggesting the need for chemotherapy in addition to MTX discontinuation in CHL‐type MTX‐LPD patients to achieve complete remission. No association was observed between PD‐L1 expression levels and clinical findings at diagnosis, suggesting that PD‐L1 expression in tumor cells influences the pathogenesis of CHL‐type MTX‐LPD after MTX discontinuation.
Patients with classic Hodgkin lymphoma (CHL)‐type methotrexate‐associated lymphoproliferative disorder (MTX‐LPD) with high programmed cell death‐ligand 1 (PD‐L1) expression tended to have exacerbations and relapses after MTX discontinuation. Our study suggests that the PD‐1/PD‐L1 pathway may be involved in refractoriness to MTX discontinuation in CHL‐type MTX‐LPD.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0febac51292e55b26e6f5b3df183fcd5Test
https://doaj.org/article/6e2da9f68eeb4074af0bba01de8c7953Test

4

Comparative clinical outcomes of insulin degludec and insulin glargine 300 U/mL after switching from other basal insulins in real‐world patients with type 1 and type 2 diabetes

المؤلفون: Yukiko Hasegawa, Tetsuya Babazono, Junko Oya, Aki Katamine, Tomoko Nakagami, Yuichiro Kondo

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 11, Pp 1983-1991 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Insulin degludec, Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulins, Insulin Glargine, Type 2 diabetes, 030204 cardiovascular system & hematology, Body Mass Index, chemistry.chemical_compound, 0302 clinical medicine, Japan, Drug Substitution, Insulin glargine 300 U/mL, General Medicine, Articles, Middle Aged, Insulin, Long-Acting, Treatment Outcome, Clinical Science and Care, Female, Original Article, medicine.drug, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Real‐world clinical setting, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Aged, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Insulin glargine, business.industry, Insulin, medicine.disease, RC648-665, Endocrinology, Diabetes Mellitus, Type 1, Logistic Models, Basal (medicine), chemistry, Diabetes Mellitus, Type 2, Glycated hemoglobin, business

الوصف: Aims/Introduction To evaluate and compare the efficacy of insulin degludec (IDeg) and insulin glargine 300 U/mL (Gla300) 6 months after switching from other basal insulins by assessing the changes in glycated hemoglobin (HbA1c), body mass index (BMI), and insulin doses in patients with type 1 and type 2 diabetes in a real‐world clinical setting. Materials and Methods A total of 307 patients with type 1 diabetes and 294 patients with type 2 diabetes with HbA1c >7.0% were studied. Adjusted mean changes in HbA1c, BMI, and insulin doses were compared between IDeg (IDeg group) and Gla300 (Gla300 group) switchers. Multivariable logistic regression analyses were carried out to examine whether the IDeg or Gla300 group was associated with HbA1c or insulin dose reduction and BMI gain. Results HbA1c was significantly decreased in both the IDeg and Gla300 groups. Adjusted mean changes in HbA1c (approximately −0.3% and −0.5% in type 1 diabetes and type 2 diabetes patients, respectively) and BMI were similar between both groups. The mean change in insulin dose was slightly larger for dose reduction in the IDeg group than in the Gla300 group. Multivariable logistic regression models showed that the IDeg group was significantly associated with insulin dose reduction after adjusting for basal insulin type, insulin dose, and number of basal insulin injections at baseline and other confounding factors. Conclusions The current study suggested that IDeg and Gla300 have similar effects in reducing HbA1c and gaining BMI after switching from other basal insulins in Japanese patients with type 1 diabetes and type 2 diabetes. IDeg selection was associated with insulin dose reduction.
Insulin degludec and insulin glargine 300 U/mL showed similar values of reduction in glycated hemoglobin with body mass index almost unchanged 6 months after switching from other basal insulins in both type 1 and type 2 diabetes patients. Switching to insulin degludec was significantly associated with a reduction of basal and total insulin doses in both type 1 and type 2 diabetes patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd8e343952d329f98d4b6977a3a8fce5Test
https://doaj.org/article/33e2f17798204034beea375b21f2d506Test

5

Determination of insulin-related lipohypertrophy frequency and risk factors in patients with diabetes

المؤلفون: Asena Gökçay Canpolat, Sevim Güllü, Fatma Nur Korkmaz

المصدر: Endocrinología, Diabetes y Nutrición. 69:354-361

الوصف: Introduction Insulin, which is used in the treatment of diabetes mellitus (DM), may lead to the development of lipohypertrophy (LH) which can negatively affect the management of diabetes mellitus. Two common methods to detect LH are palpation and superficial subcutaneous ultrasonography (SSU). We investigated the frequency of non-palpable LH using SSU, as well as examining risk factors. Method We included in our study patients who had been receiving insulin injections at least twice a day for over one year without palpable LH. The epidermis and the subcutaneous tissue thickness of each region were examined using SSU. The presence of LH and associated risk factors for LH were evaluated. Results We included 136 patients in our study. The mean age of all patients was 52.87 ± 14.93 years, 59.6% were female and 73.5% had type 2 DM. The duration of DM and insulin usage were 15.76 ± 9.20 and 11.42 ± 8.26 years, respectively. The mean body mass index (BMI) of all patients was 30.59 ± 7.40 kg/m2. Non-palpable LH was detected in 87.5% (n = 116) of the patients using SSU. In the multivariate logistic regression analyses, total cholesterol level, short-acting insulin dose and coronary artery disease (CAD) were associated with LH presence. Conclusion Non-palpable LH can be seen at high rates in patients who have multiple insulin injections. Palpation is likely not enough to detect LH and we believe it would be appropriate to evaluate the presence of LH using SSU, especially for those who need high-dose insulin to control hyperglycaemia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ca985f5d54af6a37d668ceb1bc7a18Test
https://doi.org/10.1016/j.endinu.2021.07.002Test

6

Epidemiological characteristics of diabetic kidney disease in Taiwan

المؤلفون: Kun-Der Lin, Jun-Sing Wang, Chih-Cheng Hsu, Yueh-Han Hsu, Fu-Shun Yen, Shyi-Jang Shin

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 12, Pp 2112-2123 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Taiwan, Review Article, Type 2 diabetes, Prognostic factors, Diseases of the endocrine glands. Clinical endocrinology, End stage renal disease, Young Adult, Renal Dialysis, Internal medicine, Diabetes mellitus, Prevalence, Internal Medicine, medicine, Humans, Diabetic Nephropathies, Diabetic kidney disease, Family history, education, Dialysis, Aged, Type 1 diabetes, education.field_of_study, business.industry, Incidence, General Medicine, Middle Aged, RC648-665, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Risk factors, Kidney Failure, Chronic, Female, business, Dyslipidemia

الوصف: Diabetic kidney disease (DKD) is a critical microvascular complication of diabetes. With the continuous increase in the prevalence of diabetes since 2000, the prevalence of DKD has also been increasing in past years. The prevalence of DKD among individuals with type 2 diabetes in Taiwan increased from 13.32% in 2000 to 17.92% in 2014. The cumulative incidence of DKD among individuals with type 1 diabetes in Taiwan was higher than 30% during 1999–2012. DKD is the leading cause of end‐stage renal disease (ESRD), with a prevalence of approximately 45% in a population on chronic dialysis in Taiwan. Among individuals with type 2 diabetes, the prevalence of ESRD in the receipt of dialysis also increased from 1.32% in 2005 to 1.47% in 2014. Risk factors for DKD development are age, race, family history, hyperglycemia, hypertension, dyslipidemia, dietary patterns, and lifestyles. Prognostic factors that aggravate DKD progression include age, family history, sex, glycemic control, blood pressure (BP), microvascular complications, and atherosclerosis. This review summarizes updated information on the onset and progression of DKD, particularly in the Taiwanese population. Translating these epidemiological features is essential to optimizing the kidney care and improving the prognosis of DKD in Asian populations.
This review summarizes updated information on the onset and progression of DKD, particularly in Taiwan. Translating these epidemiological features is essential to optimizing kidney care and improving the prognosis of DKD in Asian populations.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1157b0db864fd756da0757f4168a35eTest
https://doi.org/10.1111/jdi.13668Test

7

Association between influenza and the incidence rate of new‐onset type 1 diabetes in Japan

المؤلفون: Sadanori Okada, Takehiro Sugiyama, Tomoaki Imamura, Tomoya Myojin, Hitoshi Ishii, Tsuneyuki Higashino, Tatsuya Noda, Shinichiro Kubo, Hiroki Nakajima, Yuichi Nishioka

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 10, Pp 1797-1804 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Population, 030209 endocrinology & metabolism, Rate ratio, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, symbols.namesake, 0302 clinical medicine, Japan, Diabetes mellitus type 1, Internal medicine, Diabetes mellitus, Influenza, Human, Internal Medicine, medicine, Humans, Poisson regression, Child, education, Aged, Retrospective Studies, Type 1 diabetes, education.field_of_study, business.industry, Incidence, Infant, Retrospective cohort study, Original Articles, General Medicine, Middle Aged, medicine.disease, RC648-665, Confidence interval, Influenza, Diabetes Mellitus, Type 1, 030104 developmental biology, Child, Preschool, Cohort, symbols, Female, Original Article, business

الوصف: Aim This study aimed to determine whether there is an association between influenza and new‐onset type 1 diabetes. Materials and methods This population‐based retrospective cohort study used data from the National Database of Health Insurance Claims and Specific Health Check‐ups of Japan. Influenza was defined based on drug prescriptions and the onset of type 1 diabetes was defined using specific medical codes indicating a diagnosis of type 1 diabetes. The incidence rate ratio of new‐onset type 1 diabetes within 180 days after an influenza diagnosis was calculated and it was compared with that at other times using Poisson regression and generalized estimating equations. Sensitivity analyses were performed to confirm the robustness of this finding. Results The data of 10,400 patients with new‐onset type 1 diabetes were analyzed, including 2,196 (952 male 1,244 female) patients diagnosed with influenza between 1 September 2014 and 31 August 2017. Although only patients with type 1 diabetes were included, adjusted analysis showed that individuals had a 1.3‐fold (95% confidence interval: 1.15–1.46) higher risk of developing type 1 diabetes in the first 180 days after influenza diagnosis than that at other times. Conclusions In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes may increase after the diagnosis of influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.
In this Japanese population‐based cohort, the risk of new‐onset type 1 diabetes increased after being diagnosed with influenza. These results, which must be confirmed in other populations, suggest that influenza may be a causal factor for new‐onset type 1 diabetes. The molecular mechanisms underlying the potential etiological relationship between influenza and type 1 diabetes should be elucidated.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2addc8fa0427d6b6ec3052b564d1117Test
https://doaj.org/article/6e005e4f525042c88b95614b668a0c6dTest

8

Prevalence and Risk Evaluation of Diabetic Complications of the Foot Among Adults With Type 1 and Type 2 Diabetes in a Large Canadian Population (PEDAL Study)

المؤلفون: Lisa Chu, Ronnie Aronson, Ruth E. Brown, Nicole Joseph

المصدر: Canadian Journal of Diabetes. 45:588-593

الوصف: Objectives The lower limb complications of diabetes contribute significantly to patient morbidity and health-care costs in Canada. Despite practice guidelines, awareness of and screening for modifiable early pathologies has been inconsistent. Our study objective was to determine the prevalence and types of early foot pathology in a large, Canadian, community care–based diabetes population. Methods This study was a retrospective, observational analysis of the LMC Diabetes & Endocrinology foot care program launched in 2017. We examined foot pathologies associated with vascular, nerve, nail and dermatologic complications, as well as foot deformities. Individuals ≥18 years of age with diabetes, assessed by an LMC chiropodist in Ontario between February 2018 and April 2019, were included in the analysis. Results Of the 5,084 individuals assessed, 470 with type 1 diabetes and 3,903 with type 2 diabetes met the study criteria. Mean age, body mass index and diabetes duration were 61.5 years, 31.3 kg/m2 and 13.9 years, respectively. Reduced pedal pulses, sensory neuropathy and onychomycosis were reported in 8.9%, 16.7% and 14.5% of those in the type 1 diabetes group, and in 19.4%, 26.6% and 28.7% of those in the type 2 group, respectively. Hyperkeratosis was present in 51% and foot deformities were present in 44.5% among both groups. Foot ulcer prevalence was 1.7%, and pedal pulses, sensory neuropathy, hyperkeratosis and onychauxis, adjusted for age, sex, body mass index and diabetes duration, were each significantly associated with ulceration. Conclusions In a large foot screening program of community-based adults with diabetes, modifiable early foot pathologies were prevalent and provided further evidence of the value of consistent screening to alleviate the morbidity and economic burden of lower limb complications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3980c195f7ae5c3ad64e3979fece673eTest
https://doi.org/10.1016/j.jcjd.2020.11.011Test

9

On‐label use of sodium–glucose cotransporter 2 inhibitors might increase the risk of diabetic ketoacidosis in patients with type 1 diabetes

المؤلفون: Akira Shimada, Koichiro Atsuda, Yoichi Oikawa, Takeshi Horii

المصدر: Journal of Diabetes Investigation, Vol 12, Iss 9, Pp 1586-1593 (2021)
Journal of Diabetes Investigation

مصطلحات موضوعية: Adult, Blood Glucose, Male, Sodium–glucose cotransporter 2 inhibitor, medicine.medical_specialty, Diabetic ketoacidosis, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, 0302 clinical medicine, Japan, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Type 1 diabetes, 030212 general & internal medicine, Sodium-Glucose Transporter 2 Inhibitors, Aged, Retrospective Studies, business.industry, Incidence (epidemiology), Incidence, Hazard ratio, General Medicine, Articles, Middle Aged, medicine.disease, Prognosis, RC648-665, Confidence interval, Diabetes Mellitus, Type 1, Clinical Science and Care, Female, Original Article, business, Body mass index, Biomarkers, Cohort study, Follow-Up Studies

الوصف: Aims/Introduction This study aimed to investigate the risk of diabetic ketoacidosis (DKA) in insulin‐treated type 1 diabetes patients administered sodium–glucose cotransporter 2 (SGLT2) inhibitors in real‐world clinical practice. Materials and Methods We carried out a real‐world, retrospective, observational cohort study using Japanese Medical Data Vision, a diagnosis procedure combination database. We identified insulin‐treated adult type 1 diabetes patients enrolled from December 2018 to October 2019. We assessed the incidence and risk of DKA in type 1 diabetes patients using SGLT2 inhibitors in an ‘on‐label’ manner. Cox multivariate regression analyses were carried out to determine clinical factors linked to SGLT2 inhibitor‐associated DKA. Results Of 11,475 type 1 diabetes patients, 1,898 (16.5%) were prescribed SGLT2 inhibitors. DKA occurred in 139 (7.3%) of these patients, with 20.2 incidences per 100 person‐years. These patients also showed significantly higher DKA rates than did those not receiving SGLT2 inhibitors (hazard ratio 1.66, 95% confidence interval 1.33–2.06; P
This study investigated the risk of diabetic ketoacidosis (DKA) in type 1 diabetes patients using sodium–glucose cotransporter 2 (SGLT2) inhibitors in an ‘on‐label’ manner. We found that SGLT2 inhibitors might increase the DKA risk among insulin‐treated type 1 diabetes patients irrespective of sex, age and body mass index, and that the mean time until DKA onset in SGLT2 inhibitor‐treated type 1 diabetes patients was 30.6 days. Physicians should fully consider the appropriate use of SGLT2 inhibitors in type 1 diabetes patients to prevent DKA.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274d7c5c3890b639e90830aea459600aTest
https://doaj.org/article/52f48c8ed5824dd092e6adafd3588fbaTest

10

Tumor immunity is related to 18F‐FDG uptake in thymic epithelial tumor

المؤلفون: Kyoichi Kaira, Ou Yamaguchi, Hiroyuki Nitanda, Hirozo Sakaguchi, Akitoshi Yanagihara, Hiroshi Kagamu, Tomonori Kawasaki, Tetsuya Umesaki, Kunihiko Kobayashi, Atsuto Mouri, Hisao Imai, Kosuke Hashimoto, Ryo Taguchi, Ichiei Kuji, Masanori Yasuda

المصدر: Cancer Medicine, Vol 10, Iss 18, Pp 6317-6326 (2021)
Cancer Medicine

مصطلحات موضوعية: Male, Cancer Research, Pathology, Biopsy, B7-H1 Antigen, Warburg Effect, Oncologic, Neoplasms, Glandular and Epithelial, Thymic carcinoma, Research Articles, RC254-282, Aged, 80 and over, Glucose Transporter Type 1, medicine.diagnostic_test, biology, HIF‐1α, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Middle Aged, Thymectomy, Oncology, Positron emission tomography, thymic epithelial tumor, immunohistochemistry, Immunohistochemistry, Female, medicine.symptom, Research Article, Adult, medicine.medical_specialty, Thymoma, Thymus Gland, Fluorodeoxyglucose F18, PD-L1, medicine, Humans, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies, Performance status, business.industry, Clinical Cancer Research, Thymus Neoplasms, Hypoxia (medical), medicine.disease, Hypoxia-Inducible Factor 1, alpha Subunit, Programmed Cell Death 1 Ligand 2 Protein, PD‐L1, Positron-Emission Tomography, PD‐L2, biology.protein, Tumor Hypoxia, GLUT1, 18F‐FDG uptake, business

الوصف: Background 2‐deoxy‐2‐[fluorine‐18] fluoro‐d‐glucose (18F‐FDG) positron emission tomography (18F‐FDG‐PET) is a convenient modality to assess the metabolic activity within tumor cells. However, there is no consensus regarding the relationship between 18F‐FDG uptake and the immune environment in thymic epithelial tumors (TETs). We conducted a clinicopathological study to elucidate the relationship between 18F‐FDG uptake and programmed death ligands 1 and 2 (PD‐L1/PD‐L2) expression in patients with TETs. Methods: A total of 108 patients with histologically confirmed TETs classified as thymomas or thymic carcinomas who underwent surgical resection or biopsy or needle biopsy and 18F‐FDG PET before any treatment between August 2007 and March 2020 were enrolled in this study. Tumor specimens underwent immunohistochemical staining for PD‐L1, PD‐L2, GLUT1, HIF‐1α, VEGFR2, VEGF‐C, and β2 adrenergic receptor. Results: High uptakes of SUVmax, SUVmean, MTV, and TLG were identified in 28 (25.9%), 61 (56.5%), 55 (50.9%), and 55 (50.9%) of 108 patients, respectively. High uptake of SUVmax significantly correlated with PS (performance status) of 1–2, thymic carcinoma, and advanced stage, and SUVmax on 18F‐FDG uptake displayed a close association with PD‐L1 and PD‐L2 expressions, but not with MTV and TLG. Our analysis revealed that SUVmax was identified as being significant relationship for positive PD‐L1/PD‐L2 expression. GLUT1, HIF‐1α, and VEGFR2 were significantly associated with the expression of PD‐L1/PD‐L2 from the biological viewpoint. Conclusion 18F‐FDG accumulation was closely associated with the expression of PD‐L1/PD‐L2, which, in turn, was correlated with glucose metabolism and hypoxia. PD‐L1/PD‐L2 could affect the glucose metabolism and hypoxia in thymic tumor cells.
High expression of PD‐L1/PD‐L2 was closely associated with high accumulation of 18F‐FDG. Angiogenetic markers were linked to the expression of PD‐L1/PD‐L2. PD‐L1 and PD‐L2 exhibited a close relationship with upregulation of tumor glucose metabolism and hypoxia.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15261651d62bd866f1c6478c8c6c3373Test
https://doaj.org/article/a8142366e6a1438799401c111ae0c803Test

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