A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male
| العنوان: | A rare case of an aldosterone secreting metastatic adrenocortical carcinoma and papillary thyroid carcinoma in a 31-year-old male |
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| المؤلفون: | James M. Ford, Marina Basina, Daniel T. Chang, Ralph S. Greco, Stephen M. Wanta, Steven D. Chang, Kerry Kingham, Robert E. Merritt, Pamela L. Kunz |
| المصدر: | Rare Tumors Rare Tumors, Vol 3, Iss 4, Pp e45-e45 (2011) |
| بيانات النشر: | PAGEPress Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Histology, endocrine system diseases, hereditary cancer syndrome, Case Report, lcsh:RC254-282, Thyroid carcinoma, chemistry.chemical_compound, medicine, adrenocortical carcinoma, Adrenocortical carcinoma, Mitotane, Lung, Aldosterone, business.industry, Thyroid, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Hyperaldosteronism, medicine.anatomical_structure, Oncology, chemistry, Li–Fraumeni syndrome, papillary thyroid carcinoma, Adrenocortical carcinoma, papillary thyroid carcinoma, hereditary cancer syndrome, business, medicine.drug |
| الوصف: | We report a rare synchronous presentation of adrenocortical carcinoma (ACC) and papillary thyroid carcinoma (PTC). A 31-year-old male first presented with a large left adrenal mass that was identified during the workup for refractory hypertension due to hyperaldosteronism. The mass was removed surgically with pathology showing ACC. The patient was then treated with adjuvant radiation therapy and mitotane chemotherapy. Four months post ACC resection, metastatic ACC to the right upper lung and PTC in the left lobe of the thyroid were found in surveillance imaging. He subsequently developed pulmonary, contralateral adrenal and brain metastases from his ACC. Li Fraumeni syndrome and Multiple Endocrine Neoplasia Type I (MEN I) were considered, but testing of both P53 and menin genes showed no mutation. We also performed a review of the literature and found three similar cases, however gene mutation analysis was not performed.. |
| اللغة: | English |
| تدمد: | 2036-3613 2036-3605 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd18281ff1efc1b1b708c74464b7963eTest http://europepmc.org/articles/PMC3282450Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd18281ff1efc1b1b708c74464b7963e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20363613 20363605 |
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