التفاصيل البيبلوغرافية
| العنوان: |
Adrenal ganglioneuromas: a retrospective multicentric study of 104 cases from the COMETE network. |
| المؤلفون: |
Deflorenne, Elisa, Peuchmaur, Michel, Vezzosi, Delphine, Ajzenberg, Christiane, Brunaud, Laurent, Chevalier, Nicolas, Christin-Maitre, Sophie, Decoudier, Bénédicte, Driessens, Natacha, Drui, Delphine D., Gilly, Olivier, Goudet, Pierre, Illouz, Frédéric, Jublanc, Christel, Lefebvre, Hervé, Lopez, Antoine-Guy, Lussey, Charlotte, Morini, Aurelien, Raffin-Sanson, Marie-Laure, Raingeard, Isabelle |
| المصدر: |
European Journal of Endocrinology; Oct2021, Vol. 185 Issue 4, p463-474, 12p |
| مصطلحات موضوعية: |
ADRENAL tumors, COMPUTED tomography, SYMPATHETIC nervous system, PERIPHERAL nervous system |
| مستخلص: |
Objective: Adrenal ganglioneuromas are rare, differentiated, neuroblastic tumors that originate from the peripheral sympathetic nervous system. Because of their rarity, informatio n is limited, derived from small cases series. Our objective was to characterize this tumor and provide help for i ts management. Methods: A retrospective multicenter analysis of adrenal ganglioneuroma s from 20 French centers belonging to the COMETE network and one Belgian center. Results: Among the 104 cases identified, 59.6% were women (n = 62/104), median age at diagnosis was 29 years, with 24 pediatric cases. 60.6% (n = 63/104) were incidentalomas. Ganglioneuromas were non-secreting tumors in 90.8% of cases (n = 89/98), whereas the preoperative hormonal evaluation was indet erminate for 9.2% of patients (n = 9/98). CT imaging, performed on 96 patients, revealed large tumors (media n diameter of 50 mm) with a non-contrast density > 10 Hounsfield units in 98.1% (n = 52/53) and calcifications in 64.6% of cases (n = 31/48). Increased uptake on 123I-MIBG scintigraphy and 18F-FDG-PET/CT was observed in 26.7% (n = 8/30) and 42.2% (n = 19/45) of the tumors, respectively. All 104 patients underwent surgery. No recurrence was observed among the 42 patients who had an imaging follow-up (mean 29.6 months, median 18 months (4-156)). Conclusion: Adrenal ganglioneuromas are large tumors, mostly nonfunctionin g, without benign imaging features. Although the duration of follow-up was limited in our series, no recurrence was identified. A review of the literature confirms the absence of postoperative recurrence. Based on all a vailable data, in the absence of special circumstances (genetic form, uncertain histological diagnosis), long-term follow-up is not necessary after complete surgery for patients with an adrenal ganglioneuroma. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Endocrinology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder