المؤلفون: Kent Lam, Randall A Bloch, Matthew J. Lelegren

المصدر: Ear, nose,throat journal. 100(5)

مصطلحات موضوعية: medicine.medical_specialty, Intraoperative Care, business.industry, Topical Corticosteroid Therapy, Chronic rhinosinusitis, Endoscopy, Surgery, Endoscopic sinus surgery, Treatment Outcome, Otorhinolaryngology, Adrenal Cortex Hormones, Chronic Disease, Paranasal Sinuses, medicine, Humans, Sinusitis, business, Rhinitis

الوصف: Objectives: To provide an overview of recent techniques and technologies for the application of topical corticosteroid therapy immediately following endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). Methods: A comprehensive search in the PubMed and Google Scholar databases was conducted to identify publications between January 2000 and December 2019 detailing clinical trials that have evaluated the efficacy and safety of intraoperative applications of topical corticosteroids for CRS. Results: A total of 21 articles, all of which highlight a variety of corticosteroid-infused products, including Propel corticosteroid-eluting stents, NasoPore, Merocel, SinuBand, calcium alginate, and bioresorbable gel-type products, are included for review. Propel stents are the only devices that have achieved level 1A evidence in terms of efficacy and have data to support their safety. The remaining products have shown mixed results in terms of efficacy and safety. Conclusion: A wide range of techniques and technologies have been introduced to enhance the topical delivery of corticosteroids into the neosinuses after ESS for CRS. Regarding efficacy, there is level 1A evidence to support the use of Propel stents. Most of the remaining strategies show some degree of efficacy. Direct comparisons across the different strategies are limited owing to the varied uses of delivery vectors, corticosteroid choices, and doses of corticosteroids. Propel stents and SinuBand have sufficient data to support systemic and ocular safety, whereas the remaining products have limited data to support their safety.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9e2cc816e1ede3b2bf42ff02dc25feTest
https://pubmed.ncbi.nlm.nih.gov/33170026Test

المؤلفون: Garret O’Connell, Cathal O'Connor, Michelle Murphy, L Roche, E. Nic Dhonncha, Catherine Quinlan

المصدر: Clinical and experimental dermatologyReferences. 46(4)

مصطلحات موضوعية: Adult, Aged, 80 and over, Vulvar Lichen Sclerosus, medicine.medical_specialty, Cross-sectional study, Topical Corticosteroid Therapy, business.industry, Administration, Topical, MEDLINE, Dermatology, Middle Aged, Drug Prescriptions, Medication Adherence, Cross-Sectional Studies, Adrenal Cortex Hormones, medicine, Humans, Female, Prospective Studies, business, Aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066d647a90151f70bad35c3f14645ac6Test
https://pubmed.ncbi.nlm.nih.gov/33247952Test

المؤلفون: Masahiko Goya, Claire A. Martin, Yasuhiro Shirai, Junji Yamaguchi, Tetsuo Sasano, Masateru Takigawa

المصدر: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 23(3)

مصطلحات موضوعية: medicine.medical_specialty, Pulse (signal processing), business.industry, medicine.disease, Atrioventricular node, Electrocardiography, Steroid therapy, Text mining, medicine.anatomical_structure, Corticosteroid therapy, Adrenal Cortex Hormones, Heart Rate, Physiology (medical), Internal medicine, Tachycardia, Ectopic Junctional, Junctional ectopic tachycardia, medicine, Cardiology, Atrioventricular Node, Humans, Cardiology and Cardiovascular Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27342738655e58fb559029baa560627Test
https://pubmed.ncbi.nlm.nih.gov/33068003Test

المؤلفون: Frédéric Gonzalez, Laurent Chow-Chine, Magali Bisbal, Luca Servan, Jérôme Lambert, Antoine Sannini, Norbert Vey, Mehdi Assal, Marion Faucher, Djamel Mokart, Jean Manuel de Guibert

المصدر: PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250611 (2021)

مصطلحات موضوعية: Oncology, Male, Pulmonology, medicine.medical_treatment, Severity of Illness Index, Steroid Therapy, Hematologic Cancers and Related Disorders, Medical Conditions, Adrenal Cortex Hormones, Medicine and Health Sciences, Intubation, Multidisciplinary, Hematology, Pharmaceutics, Mortality rate, Pneumonia, Pneumocystis, Fungal Diseases, Middle Aged, Prognosis, Survival Rate, Treatment Outcome, Infectious Diseases, Hematologic Neoplasms, Medicine, Female, Research Article, medicine.medical_specialty, Death Rates, Science, Corticosteroid Therapy, Surgical and Invasive Medical Procedures, Drug Therapy, Population Metrics, Internal medicine, medicine, Humans, Transplantation, Homologous, Propensity Score, Aged, Proportional Hazards Models, Retrospective Studies, Population Biology, business.industry, Pneumocystis, Cancer, Biology and Life Sciences, Cancers and Neoplasms, Retrospective cohort study, Pneumonia, medicine.disease, Transplantation, Co-Infections, Propensity score matching, business, Tomography, X-Ray Computed, Stem Cell Transplantation

الوصف: Purpose While early adjunctive corticosteroid therapy (EACST) has been proven effective in HIV patients with Pneumocystis Jirovecii Pneumonia (PJP), data remains controversial concerning non-HIV oncology or haematology patients. Methods This retrospective study included cancer patients without HIV and with diagnosis of PJP admitted in a cancer referral centre, from January-1-2010 to March-31-2017. We compared 30-day and 1-year mortality rate, change in the respiratory item of the Sequential Organ Failure Assessment score(SOFA-resp worsening), use of tracheal intubation between day-1 and day-5 of anti-pneumocystis therapy and occurrence of coinfections between patients with EACST and those with no or late corticosteroid therapy, using an inverse probability weighting propensity score-based (IPW) analysis. Results 133 non-HIV oncology or haematology PJP patients were included (EACST n = 58, others n = 75). The main underlying conditions were haematological malignancies (n = 107, 80,5%), solid tumour (n = 27, 20,3%) and allogeneic stem cell transplantation (n = 17, 12,8%). Overall 30-day and 1-year mortality rate was 24,1% and 56,4%, respectively. IPW analysis found no difference on 30-day (HR = 1.45, 95% CI [0.7–3.04], p = 0.321) and 1-year (HR = 1.25, CI 95% [0.75–2.09], p = 0.39) mortality rate between groups. Conclusion No difference in SOFA-resp worsening, tracheal intubation and coinfections was found between groups. Combination of EACST with anti-pneumocystis therapy in non-HIV onco-haematology PJP-patients was not associated with clinical improvement.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a3dd1eaac21f5b921b5817beb185acTest
https://pubmed.ncbi.nlm.nih.gov/33886692Test

المؤلفون: Shinji Kawabe, Akimichi Morita, Naomi Iwata, Naoki Abe, Haruna Nakaseko, Emi Nishida, Toaki Kohagura

المصدر: Modern rheumatology case reports. 5(1)

مصطلحات موضوعية: medicine.medical_specialty, medicine.drug_class, business.industry, Treatment options, Arthritis, medicine.disease, Dermatology, Combined Modality Therapy, Pyoderma Gangrenosum, Discontinuation, Treatment Outcome, Corticosteroid therapy, Adrenal Cortex Hormones, Recurrence, medicine, Corticosteroid, Humans, Female, business, Skin lesion, Child, Pyoderma gangrenosum, Immunosuppressive Agents

الوصف: An 8-year-old girl was presented to our clinic with fever, arthritis in her left knee, a necrotic right fifth toe, and multiple large deep-seated ulcerations. She was diagnosed with pyoderma gangrenosum. Treatment with corticosteroids alone was ineffective for her skin lesions, and therefore combination immunosuppressant therapy was administered. Her skin lesions rapidly improved, enabling discontinuation of the corticosteroid therapy and avoiding systemic infection through the ulcers. Combination immunosuppressant therapy may be a treatment option for patients with severe, rapidly progressive pyoderma gangrenosum.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b4c2bf61fbbd79a216483f77e3616eTest
https://pubmed.ncbi.nlm.nih.gov/33016252Test

المؤلفون: Nicola Personeni, ChiehJu Lee, Anushi Bulumulle, Anwaar Saeed, Abdul Rafeh Naqash, Petros Fessas, Tomi Jun, Musharraf Navaid, Bo Yu, Celina Ang, Yinghong Wang, Hannah Hildebrand, Ahmed Kaseb, David J. Pinato, Jingky Lozano-kuehne, Tiziana Pressiani, Dominik Bettinger, David Szafron, Thomas U. Marron, Lorenza Rimassa, Mahvish Muzaffar, Yehia I. Abugabal, Sirish Dharmapuri, Uqba Khan, Sonal Paul, Yi Hsiang Huang, Neil Nimkar

المصدر: Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, medicine.medical_specialty, 2019-20 coronavirus outbreak, Poor prognosis, Carcinoma, Hepatocellular, Immune checkpoint inhibitors, Immunology, Short Report, immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Overall response rate, Prednisone, Adrenal Cortex Hormones, Internal medicine, medicine, Immunology and Allergy, Humans, Prospective Studies, Adverse effect, Immune Checkpoint Inhibitors, RC254-282, Pharmacology, Science & Technology, liver neoplasms, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 3. Good health, 030104 developmental biology, Treatment Outcome, Corticosteroid therapy, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Molecular Medicine, Female, ADVERSE EVENTS, business, Life Sciences & Biomedicine, medicine.drug

الوصف: The impact of corticosteroid therapy (CT) on efficacy of immune checkpoint inhibitors (ICI) is undefined in hepatocellular carcinoma (HCC). We evaluated whether CT administered at baseline (bCT) or concurrently with ICI (cCT) influences overall (OS), progression-free survival (PFS) and overall response rates (ORR) in 341 patients collected across 3 continents. Of 304 eligible patients, 78 (26%) received >10 mg prednisone equivalent daily either as bCT (n=14, 5%) or cCT (n=64, 21%). Indications for CT included procedure/prophylaxis (n=37, 47%), management of immune-related adverse event (n=27, 35%), cancer-related symptoms (n=8, 10%) or comorbidities (n=6, 8%). Neither overall CT, bCT nor cCT predicted for worse OS, PFS nor ORR in univariable and multivariable analyses (p>0.05). CT for cancer-related indications predicted for shorter PFS (p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ea12367e000bff0d4273d97fed2df5Test
http://europepmc.org/articles/PMC7542664Test

المؤلفون: Biao Zhang, Chao Wu, Huaping Shao, Xiang-An Zhao, Yun Zhao, Yuxin Chen, Jie Wei, Fang Ming, Tianmin Xu, Songping Huang, Chunyang Li, Xinying Guan, Longgen Liu, Leyang Xue, Juan Cheng, Li Zhu, Rui Huang, Xiaomin Yan, Xuebing Yan, Rahma Issa, Jian Wang, Dawen Sang, Haiyan Zhao, Chuanwu Zhu, Xiaobing Chen

المصدر: European Journal of Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), medicine.drug_class, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Gastroenterology, Methylprednisolone, 03 medical and health sciences, 0302 clinical medicine, Sex Factors, Adrenal Cortex Hormones, Risk Factors, Internal medicine, Full Length Article, medicine, Humans, Corticosteroid, Pandemics, Retrospective Studies, Pharmacology, Coronavirus disease 2019, Proportional hazards model, business.industry, SARS-CoV-2, Hazard ratio, Virus clearance, COVID-19, Middle Aged, Confidence interval, COVID-19 Drug Treatment, 030104 developmental biology, Corticosteroid therapy, Respiratory failure, Female, business, 030217 neurology & neurosurgery

الوصف: The impact of corticosteroid treatment on virological course of coronavirus disease 2019 (COVID-19) patients remains unclear. This study aimed to explore the association between corticosteroid and viral clearance in COVID-19. The clinical data of COVID-19 patients from 10 hospitals of Jiangsu, China, were retrospectively collected. Cox regression and Kaplan-Meier analysis were used to analyze the adverse factors of virus clearance. Of the 309 COVID-19 patients, eighty-nine (28.8%) patients received corticosteroid treatment during hospitalization. Corticosteroid group showed higher C-reactive protein (median 11.1 vs. 7.0 mg/l, P = 0.018) and lower lymphocytes (median 0.9 vs. 1.4 × 109/l, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e53e09cb6b49bf9b2b105a1956d2138Test
http://europepmc.org/articles/PMC7490250Test

المؤلفون: Deepsekhar Das, Neelima Balakrishnan, Rachna Meel

المصدر: BMJ Case Rep

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Images In…, business.industry, Prednisolone, Administration, Oral, General Medicine, 030105 genetics & heredity, Middle Aged, Dermatology, Magnetic Resonance Imaging, eye diseases, Diagnosis, Differential, Graves Ophthalmopathy, 03 medical and health sciences, 0302 clinical medicine, Corticosteroid therapy, Adrenal Cortex Hormones, Immunoglobulin G, Medicine, Outpatient clinic, Humans, business, 030217 neurology & neurosurgery

الوصف: A 45-year-old man presented to the outpatient department with symptoms of outward protrusion of both eyes for the past 20 years ([figure 1][1]). The swelling was gradually progressive in nature, painless and more on the right side. It was associated with redness and watering. There was no history of

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efccbedcde53388abd1c1967dd247d55Test
https://europepmc.org/articles/PMC7451535Test/

المؤلفون: Masatoshi Miyamura, Fumio Terasaki, Yumiko Kanzaki, Tomoshige Morimoto, Hideki Fujiyoshi, Masanao Inoue, Shuichi Fujita, Masaaki Hoshiga

المصدر: Internal Medicine

مصطلحات موضوعية: medicine.medical_specialty, Sarcoidosis, medicine.drug_class, diagnostic imaging, Inflammation, Case Report, Cardiac sarcoidosis, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Adrenal Cortex Hormones, Fluorodeoxyglucose F18, Internal medicine, Internal Medicine, medicine, Sustained VT, Humans, Fluorodeoxyglucose, Fluorine-18-fluorodeoxyglucose, business.industry, ventricular dysfunction, General Medicine, Middle Aged, life-threatening arrhythmias, Corticosteroid therapy, Sustained ventricular tachycardia, Cardiology, cardiovascular system, Tachycardia, Ventricular, Corticosteroid, 030211 gastroenterology & hepatology, Female, medicine.symptom, business, Cardiomyopathies, disease activity, medicine.drug

الوصف: We herein report a woman diagnosed with cardiac sarcoidosis (CS) based on the presence of epithelioid granulomas in non-cardiac organs and clinical findings including sustained ventricular tachycardia (VT) and cardiac dysfunction. She stopped oral corticosteroid after 4 years of treatment, and an abnormal myocardial uptake of fluorine-18 fluorodeoxyglucose and sustained VT recurred 3.5 years later. There is no consensus concerning whether or not corticosteroid therapy should be discontinued in the treatment of CS. As a relapse of sarcoidosis-related inflammation may be associated with life-threatening arrhythmia, some patients should continue corticosteroid therapy, even at low doses.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a810e5ff11b2cafbeaf52cc6f16108Test
https://pubmed.ncbi.nlm.nih.gov/32536643Test

المؤلفون: Jian Yu, You Yang, Feng Lv, Su Min, Li Ren

المصدر: PLoS ONE
PLoS ONE, Vol 15, Iss 8, p e0237174 (2020)

مصطلحات موضوعية: Male, Epidemiology, medicine.medical_treatment, Network Meta-Analysis, Endotracheal intubation, Steroid Therapy, 0302 clinical medicine, Drug Delivery Systems, Postoperative Complications, Mathematical and Statistical Techniques, 030202 anesthesiology, Adrenal Cortex Hormones, Sore throat, Medicine and Health Sciences, Medicine, Intubation, Magnesium, 030212 general & internal medicine, Multidisciplinary, Pharmaceutics, Incidence (epidemiology), Incidence, Statistics, Pharyngitis, Middle Aged, Metaanalysis, Research Assessment, Chemistry, Treatment Outcome, Meta-analysis, Physical Sciences, Female, Ketamine, medicine.symptom, Anatomy, medicine.drug, Research Article, Chemical Elements, Adult, medicine.medical_specialty, Systematic Reviews, Science, Corticosteroid Therapy, MEDLINE, Surgical and Invasive Medical Procedures, Anesthesia, General, Research and Analysis Methods, Throat, 03 medical and health sciences, Drug Therapy, Administration, Inhalation, otorhinolaryngologic diseases, Intubation, Intratracheal, Humans, Statistical Methods, Intensive care medicine, Relative efficacy, business.industry, Nebulizers and Vaporizers, Biology and Life Sciences, Bayes Theorem, stomatognathic diseases, Medical Risk Factors, business, Mathematics, Neck

الوصف: Postoperative sore throat is one of the most common complications following endotracheal intubation. Nebulization therapy, a preferable and safety method of drug delivery, has been shown to be effective in postoperative sore throat prevention in many studies. However, the relative efficacy of various nebulized agents remains unknown. In this review, we aimed to quantify and rank order the efficacy of available nebulized agents for various postoperative sore throat-related outcomes. A comprehensive literature search of PubMed, EMBASE, CENTRAL and Google Scholar was conducted to identify eligible studies from inception to 25 May 2020. Incidence of postoperative sore throat 1hour and 24hours postoperatively and severity of postoperative sore throat 24 hours postoperatively were the primary outcomes. We conducted a Bayesian network meta-analysis to combine direct and indirect evidence to estimate the relative effects between treatments as well as the probabilities of ranking for treatments based on their protective effects. We identified 32 trials assessing 6 interventions. Overall inconsistency and heterogeneity were acceptable. Nebulized corticosteroids, magnesium, and ketamine differed from non-analgesic methods on the three primary outcomes. Based on the surface under the cumulative ranking curve, nebulized corticosteroids ranked first in almost all outcomes among the nebulized drugs. Considering only high-quality and 2-arm design studies, nebulized corticosteroids still seemed best. In conclusion, prophylactic use of nebulized corticosteroids, magnesium, and ketamine can effectively prevent postoperative sore throat, and nebulized corticosteroids appears to be the overall best approach.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bba9d2b856a9981489179f511e568a32Test
https://pubmed.ncbi.nlm.nih.gov/32776966Test