التفاصيل البيبلوغرافية
| العنوان: |
Functional imaging with 11C-metomidate PET for subtype diagnosis in primary aldosteronism. |
| المؤلفون: |
Soinio, Minna, Luukkonen, Anna-Kaarina, Seppänen, Marko, Kemppainen, Jukka, Seppänen, Janne, Pienimäki, Juha-Pekka, Leijon, Helena, Vesterinen, Tiina, Arola, Johanna, Lantto, Eila, Helin, Semi, Tikkanen, Ilkka, Metso, Saara, Mirtti, Tuomas, Heiskanen, Ilkka, Norvio, Leena, Tiikkainen, Mirja, Tikkanen, Tuula, Sane, Timo, Välimäki, Matti |
| المصدر: |
European Journal of Endocrinology; Dec2020, Vol. 183 Issue 6, p539-550, 12p |
| مصطلحات موضوعية: |
HYPERALDOSTERONISM, RECEIVER operating characteristic curves, ADRENAL cortex, IMMUNOSTAINING, ADRENALECTOMY, FECAL occult blood tests |
| مستخلص: |
Objective: Endocrine Society guidelines recommend adrenal venous samplin g (AVS) in primary aldosteronism (PA) if adrenalectomy is considered. We tested whether functional imagi ng of adrenal cortex with 11C-metomidate (11C-MTO) could offer a noninvasive alternative to AVS in the subtype clas sification of PA. Design: We prospectively recruited 58 patients with confirmed PA who w ere eligible for adrenal surgery. Methods: Subjects underwent AVS and 11C-MTO-PET without dexamethasone pretreatment in random order. The lateralization of 11C-MTO-PET and adrenal CT were compared with AVS in all subjects and in a prespecified adrenalectomy subgroup in which the diagnosis was confirmed with immunohistochemical staining for CYP11B2. Results: In the whole study population, the concordance of AVS and 11C-MTO-PET was 51% and did not differ from that of AVS and adrenal CT (53%). The concordance of AVS and 11C-MTO-PET was 55% in unilateral and 44% in bilateral PA. In receiver operating characteristics analysis, the maximum sta ndardized uptake value ratio of 1.16 in 11C-MTO-PET had an AUC of 0.507 (P = n.s.) to predict allocation to adrenalectomy or medical therapy with sensitivity of 55% and specificity of 44%. In the prespecified adrenalectomy subgroup, A VS and 11C-MTO-PET were concordant in 10 of 19 subjects with CYP11B2-positive adenoma and in 6 of 10 with CYP1 1B2-positivity without an adenoma. Conclusions: The concordance of 11C-MTO-PET with AVS was clinically suboptimal, and did not outpe rform adrenal CT. In a subgroup with CYP11B2-positive adenoma, 11C-MTO-PET identified 53% of cases. 11C-MTO-PET appeared to be inferior to AVS for subtype classification of PA. [ABSTRACT FROM AUTHOR] |
|
Copyright of European Journal of Endocrinology is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder