Corridors of migrating neurons in the human brain and their decline during infancy
| العنوان: | Corridors of migrating neurons in the human brain and their decline during infancy |
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| المؤلفون: | Sanai, N, Nguyen, T, Ihrie, RA, Mirzadeh, Z, Tsai, HH, Wong, M, Gupta, N, Berger, MS, Huang, E, Garcia-Verdugo, JM, Rowitch, DH, Alvarez-Buylla, A |
| المصدر: | NATURE r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) instname Nature, vol 478, iss 7369 r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF) Centro de Investigación Principe Felipe (CIPF) Sanai, N; Nguyen, T; Ihrie, RA; Mirzadeh, Z; Tsai, HH; Wong, M; et al.(2011). Corridors of migrating neurons in the human brain and their decline during infancy. Nature, 478(7369), 382-386. doi: 10.1038/nature10487. UCSF: Retrieved from: http://www.escholarship.org/uc/item/1rx9998wTest |
| بيانات النشر: | NATURE PUBLISHING GROUP, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Adolescent, General Science & Technology, 1.1 Normal biological development and functioning, Cell Movement, Underpinning research, 80 and over, Humans, Child, Preschool, reproductive and urinary physiology, Cell Proliferation, Aged, Neurons, Pediatric, Neurosciences, Brain, Infant, Olfactory Pathways, Middle Aged, Newborn, Stem Cell Research, Brain Disorders, nervous system, Neurological, Stem Cell Research - Nonembryonic - Non-Human |
| الوصف: | The subventricular zone of many adult non-human mammals generates large numbers of new neurons destined for the olfactory bulb. Along the walls of the lateral ventricles, immature neuronal progeny migrate in tangentially oriented chains that coalesce into a rostral migratory stream (RMS) connecting the subventricular zone to the olfactory bulb. The adult human subventricular zone, in contrast, contains a hypocellular gap layer separating the ependymal lining from a periventricular ribbon of astrocytes. Some of these subventricular zone astrocytes can function as neural stem cells in vitro, but their function in vivo remains controversial. An initial report found few subventricular zone proliferating cells and rare migrating immature neurons in the RMS of adult humans. In contrast, a subsequent study indicated robust proliferation and migration in the human subventricular zone and RMS. Here we find that the infant human subventricular zone and RMS contain an extensive corridor of migrating immature neurons before 18 months of age but, contrary to previous reports, this germinal activity subsides in older children and is nearly extinct by adulthood. Surprisingly, during this limited window of neurogenesis, not all new neurons in the human subventricular zone are destined for the olfactory bulb-we describe a major migratory pathway that targets the prefrontal cortex in humans. Together, these findings reveal robust streams of tangentially migrating immature neurons in human early postnatal subventricular zone and cortex. These pathways represent potential targets of neurological injuries affecting neonates. © 2011 Macmillan Publishers Limited. All rights reserved. |
| وصف الملف: | application/pdf |
| تدمد: | 0028-0836 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::06723fb487e8e6d5e603f51078fe16f4Test https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2466Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.dedup.wf.001..06723fb487e8e6d5e603f51078fe16f4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00280836 |
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