دورية أكاديمية
The Environmental Determinants of Diabetes in the Young (TEDDY) Study
| العنوان: | The Environmental Determinants of Diabetes in the Young (TEDDY) Study |
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| المؤلفون: | Rewers, Marian, Lernmark, Åke, Agardh, Daniel, Almgren, Peter, Andrén Aronsson, Carin, Ask, Maria, Carlsson, Ulla-Marie, Cilio, Corrado, Bremer, Jenny, Gerardsson, Joanna, Gustavsson, Barbro, Hansson, Gertie, Jönsson, Ida, Hansen, Monica, Hyberg, Susanne, Ivarsson, Sten, Larsson, Helena, Lernmark, Barbro, Markan, Maria, Melin, Marie Jessica, Månsson Martinez, Maria, Rahmati, Kobra, Sedig-Järvirova, Monica, Sjöberg, Birgitta, Törn, Carina, Wallin, Anne, Wigheden, Ingrid, Wimar, Åsa, TEDDY Study Group |
| المساهمون: | HASH(0x558263f53e38) |
| المصدر: | Annals of the New York Academy of Sciences; 1150, pp 1-13 (2008) ; ISSN: 0077-8923 |
| بيانات النشر: | Wiley-Blackwell |
| سنة النشر: | 2008 |
| المجموعة: | Lund University Publications (LUP) |
| مصطلحات موضوعية: | Endocrinology and Diabetes, Adolescent, Autoantibodies/analysis, Child, Preschool, Diabetes Mellitus, Type 1/epidemiology, Environment, Follow-Up Studies, Genetic Predisposition to Disease, Haplotypes, Humans, Immunologic Techniques/standards, Infant, Mass Screening, Prevalence, Risk Factors |
| الوصف: | The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet autoimmunity and T1D. From 2004-2009, TEDDY will screen more than 360,000 newborns from both the general population and families already affected by T1D to identify an estimated 17,804 children with high-risk HLA-DR,DQ genotypes. Of those, 7,801 (788 first-degree relatives and 7,013 newborns with no family history of T1D) will be enrolled in prospective follow-up beginning before the age of 4.5 months. As of May 2008, TEDDY has screened more than 250,000 newborns and enrolled nearly 5,000 infants--approximately 70% of the final cohort. Participants are seen every 3 months up to 4 years of age, with subsequent visits every 6 months until the subject is 15 years of age. Blood samples are collected at each visit for detection of candidate infectious agents and nutritional biomarkers; monthly stool samples are collected for infectious agents. These samples are saved in a central repository. Primary endpoints include (1) appearance of one or more islet autoantibodies (to insulin, GAD65 or IA-2) confirmed at two consecutive visits; (2) development of T1D. By age 15, an estimated 800 children will develop islet autoimmunity and 400 will progress to T1D; 67 and 27 children have already reached these endpoints. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://lup.lub.lu.se/record/b62c1a2d-d812-47fa-8c9c-f3e9c5cfe389Test; http://dx.doi.org/10.1196/annals.1447.062Test; pmid:19120261; scopus:57749178141 |
| DOI: | 10.1196/annals.1447.062 |
| الإتاحة: | https://doi.org/10.1196/annals.1447.062Test https://lup.lub.lu.se/record/b62c1a2d-d812-47fa-8c9c-f3e9c5cfe389Test |
| رقم الانضمام: | edsbas.4194AC2F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1196/annals.1447.062 |
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