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المصدر: Pediatric Pulmonology. 55:1375-1380
مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Spirometry, medicine.medical_specialty, Longitudinal study, Adolescent, Cystic Fibrosis, Vital Capacity, Cystic fibrosis, Gastroenterology, FEV1/FVC ratio, Forced Expiratory Volume, Internal medicine, medicine, Vitamin D and neurology, Humans, Longitudinal Studies, Vitamin D, Child, Lung, Lung function, Retrospective Studies, Level measurement, medicine.diagnostic_test, business.industry, Vitamins, respiratory system, Vitamin D Deficiency, medicine.disease, Pediatrics, Perinatology and Child Health, Positive relationship, Female, business
الوصف: BACKGROUND Vitamin D status is considered a potential determinant of lung function in cystic fibrosis (CF). The aim of this retrospective longitudinal study was to investigate the decline of spirometric values in association with vitamin D status. METHODS The data regarding 25-hydroxy vitamin D (25OHD) serum levels, spirometric measurements (FEV1, FVC, FEF25-75%), and factors known to be associated with the decline of lung function in CF were retrospectively collected over a 5-year period. The spirometric indices were recorded as the best and the average value of each year, as well as the value, recorded concurrently or closely with 25OHD level measurement. RESULTS A significantly positive relationship was observed between 25OHD serum levels and the best annual value of FEV1 (P = .034), and the values of FEV1 (P = .010) and FVC (P = .018) measured concurrently or closely with serum 25OHD levels. The evolution of the best annual value of FEV1 was worse in patients with a mean 5-year value of 25OHD levels less than 20 ng/mL compared with patients with a mean 5-year value of ≥30 ng/mL (P
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3499bcdc9f3faca5ee5f7dffecb2be21Test
https://doi.org/10.1002/ppul.24460Test -
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المؤلفون: Helen Tsapra, Andrew Fretzayas, Marianthi Galetseli, Maria Moustaki, Polyxeni Nicolaidou, P. Dimitriou
المصدر: Scandinavian Journal of Urology and Nephrology. 42:462-465
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Decompression, Urology, Urinary system, medicine.medical_treatment, media_common.quotation_subject, Urine, Urination, Urinary catheterization, Urine production, Humans, Medicine, Drainage, Child, media_common, Urinary bladder, business.industry, Water-Electrolyte Balance, Surgery, Urodynamics, medicine.anatomical_structure, Nephrology, Child, Preschool, Fluid Therapy, Female, Urinary Catheterization, business
الوصف: Although urine production depends on numerous physiological variables there are no quantitative data regarding the effect of bladder decompression, by means of continuous catheter drainage, on urine production. The aim of this study was to investigate this effect.The study was carried out in two stages, each consisting of two phases. The effect of two distinct orally administered amounts of water was recorded in relation to continuous bladder decompression on the changes with time of urine volume and the urine production rate. In the first stage, 35 children were randomly divided into two groups and two different hydration schemes (290 and 580 ml of water/m2) were used. After the second urination of Phase 1, continuous drainage was employed in the phase that followed (Phase 2). In the second stage, a group of 10 children participated and Phase 2 was carried out 1 day after the completion of Phase 1.It was shown that the amount of urine produced increased in accordance with the degree of hydration and doubled or tripled with continual urine drainage by catheter for the same degree of hydration and within the same time interval. This was also true for Stage 2, in which Phase 2 was performed 24 h after Phase 1, indicating that diuresis during Phase 2 (as a result of Phase 1) was negligible.It was shown that during continuous drainage of urine with bladder catheterization there is an increased need for fluids, which should be administered early.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65f5eab2ec30ba13d5a1cf5b181016c5Test
https://doi.org/10.1080/00365590801933101Test -
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المؤلفون: Andrew, Fretzayas, Anastasia, Stasinopoulou, Maria, Moustaki, Efstathios, Stefos, George, Kaniouras, Polyxeni, Nicolaidou
المصدر: Pediatrics international : official journal of the Japan Pediatric Society. 57(6)
مصطلحات موضوعية: Diagnosis, Differential, Adolescent, Castleman Disease, Positron-Emission Tomography, Humans, Anemia, Autoimmunity, Female, Tomography, X-Ray Computed, Magnetic Resonance Imaging, Biomarkers
الوصف: We describe herein the case of an adolescent girl with anemia non-responsive to oral iron, associated with low-grade fever, diminished appetite and fatigue. A palpable mass below the xiphoid was noted. Laboratory findings were consistent with anemia of inflammation. Direct antiglobulin test was positive without any other evidence of autoimmune anemia. Other autoantibodies, such as anti-thyroid and anti-nuclear antibodies, were also positive. After thorough investigation, Castleman disease was the most likely diagnosis on the basis of high serum interleukin (IL)-6 and the magnetic resonance imaging findings. (18)F-FDG positron emission tomography-computed tomography showed a localized hypermetabolic mass, which was resected. Castleman disease of plasma type was identified on histology. Hemogloblin and IL-6 gradually returned to normal, whereas positive autoantibodies became negative. This case emphasizes the need to investigate thoroughly for the underlying cause of anemia of inflammation and to include Castleman disease in the differential diagnosis, on the measurement of IL-6.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::75c02cee470da14f59306fd8c179e0ecTest
https://pubmed.ncbi.nlm.nih.gov/26387507Test -
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المؤلفون: Nick Dessypris, Eleni Petridou, Maria Moustaki, N. Pitsos, Maria Dalamaga
المصدر: Injury. 36:644-650
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Poison control, Knee Injuries, Suicide prevention, Occupational safety and health, Age Distribution, Leisure Activities, Epidemiology, Injury prevention, Prevalence, medicine, Cluster Analysis, Humans, Sex Distribution, Child, General Environmental Science, Greece, business.industry, Incidence (epidemiology), Infant, Newborn, Infant, Human factors and ergonomics, Emergency department, Accidents, Home, Accidents, Child, Preschool, Physical therapy, General Earth and Planetary Sciences, Female, business, human activities
الوصف: Summary Aim: To assess the relative occurrence of non motor-vehicle knee injuries and identify important clusters that can be targeted for preventive interventions. Methods: The study subjects covered 2167 children (0–14 years) who suffered non motor-vehicle knee injuries out of 66 870 registered during a three-year period in an established Emergency Department Injury Surveillance System (EDISS). A more serious joint injury was identified in 263 (12%) children, whereas the remaining 1904 children had only soft tissue knee injuries. Results: The incidence of non motor-vehicle knee injuries was estimated at 6.5 per 1000 children-years. Both the incidence of knee injuries and the male-to-female ratio increase with increasing age, reflecting the gender and age pattern of physical activity. Three clusters were identified: The first consisted of more serious knee injuries among older children, frequently resulting after a fall from stairs or a collision in school during winter months; the second cluster consisted of rather minor knee injuries occurring mostly among younger girls at home or in playgrounds, following a fall after stumbling or hit by an object while playing, especially during the summer; the third cluster comprised injuries among older boys, sustained mainly subsequent to overexertion in a sports area. Conclusion: Knee injuries tend to be more common among boys but more serious among girls. More and less serious knee injuries tend to fall into distinct clusters that could facilitate prioritisation of preventive measures.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa3d1cc22fd0717c3dec1cc1df9cd687Test
https://doi.org/10.1016/j.injury.2004.07.051Test -
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المؤلفون: Maria Moustaki, Petros M. Zeis, Themistocles Karpathios, Maria Katsikari, Maria Tsolia, Olga Grafakou, Andrew Fretzayas, S. Stabouli, Polyxeni Nicolaidou
المصدر: Pediatric Pulmonology. 35:269-273
مصطلحات موضوعية: Male, Pulmonary and Respiratory Medicine, Abdominal pain, medicine.medical_specialty, Adolescent, Radiography, medicine, Humans, Mesenteric lymph nodes, Mesentery, Child, Lymphatic Diseases, Ultrasonography, business.industry, Pneumonia, Pneumococcal, medicine.disease, Abdominal Pain, Pneumonia, medicine.anatomical_structure, Child, Preschool, Pediatrics, Perinatology and Child Health, Lobar pneumonia, Population study, Female, Lymph Nodes, Lymph, Radiology, medicine.symptom, business
الوصف: We investigated whether mesenteric lymphadenopathy could be a cause of abdominal pain in children with lobar or segmental pneumonia. The study population consisted of 1)119 consecutive children with lobar pneumonia, older than 4 years of age, and 2) 31 healthy controls. Demographic, clinical, inflammatory, and radiographic data were recorded in all patients. All study subjects underwent abdominal ultrasound, focusing on the identification of mesenteric lymphadenopathy. One month later, a follow-up ultrasound was performed in patients with enlarged mesenteric lymph nodes at the initial examination. Forty patients complaining of abdominal pain were included in group 1, while the remaining 79 were in group 2. The two groups of patients did not significantly differ regarding their demographic, clinical (other than abdominal pain), and radiographic indices. In contrast, enlarged mesenteric lymph nodes with a sagittal diameter of at least 10 mm were identified significantly more commonly in the children of group 1 (P = 0.001). The association of enlarged lymph nodes with the presence of abdominal pain remained significant when the data were analyzed through multiple regression analysis (odds raio, 1.47; 95% confidence interval, 3-44). Enlarged mesenteric lymph nodes were found in a significantly lower ratio of healthy controls (3/31) compared to that observed in group 1 (P = 0.003). In all patients who were followed up, mesenteric lymph nodes had either decreased or were not detectable. Our findings indicate that mesenteric lymphadenopathy might be considered as a mechanism responsible for the development of abdominal pain in a relatively high percentage of children with pneumonia.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d9a55d81024374c18212f83f88489faTest
https://doi.org/10.1002/ppul.10254Test -
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المؤلفون: Agelliki Chronopoulou, Dimitrios Gourgiotis, Maria Moustaki, Emmanuel Kavazarakis, Antonia Mavri, Apostolos Bossios, Petros M. Zeis, Themistocles Karpathios
المصدر: Pediatric Research. 52:454-458
مصطلحات موضوعية: Male, medicine.medical_specialty, Adolescent, Endothelium, Hyperlipidemias, chemistry.chemical_compound, Risk Factors, Internal medicine, Hyperlipidemia, medicine, Humans, Endothelial dysfunction, Child, Probability, Greece, Triglyceride, Cell adhesion molecule, Cholesterol, business.industry, Body Weight, Cholesterol, HDL, Cholesterol, LDL, medicine.disease, medicine.anatomical_structure, Endocrinology, chemistry, Pediatrics, Perinatology and Child Health, Regression Analysis, Female, business, Cell Adhesion Molecules, Body mass index, Selectin
الوصف: Cell adhesion molecules play a rather important role in the development of atherosclerosis mediating the attachment of monocytes to the endothelium. It has also been well established that hyperlipidemia is a risk factor for atherosclerosis from childhood. The aim of this study was to investigate whether the soluble adhesion molecules correlate with the circulating lipid levels in children. The study population consisted of 107 children (64 boys, 43 girls) aged 6-13 y. Parental history of cardiovascular disease, age, gender, and anthropometric parameters were recorded in all children. Blood samples were obtained from every child following a 12-hour fasting period. Serum triglycerides, total cholesterol, and its fractions as well as plasma levels of P and E selectins and adhesion molecules sVCAM-1 and sICAM-1 were determined. After controlling for age and body mass index, both sVCAM-1 and sP-selectin levels were inversely associated with HDL values (r = -0.33, p = 0.005 and r = -0.39, p = 0.001, respectively). A significant positive correlation was found between sVCAM-1 and triglycerides (r = 0.48, p < 0.001). An increment of 10 mg/dL of HDL corresponds to about 50% reduction of the odds for endothelial dysfunction whereas an increment of 10 mg/dL of triglyceride levels indicates a more than 3-fold excess risk, using either sP-selectin or sVCAM-1 levels as a surrogate for the determination of endothelial dysfunction. We suggest that HDL-C and triglycerides correlate in a biologically plausible way with soluble adhesion molecules, which therefore could be considered as useful indicators of the process of preclinical atherosclerosis even from childhood.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e0a8ab0e8f0a5ede7c4f10ceee499fTest
https://doi.org/10.1203/00006450-200209000-00025Test -
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المصدر: Scandinavian Journal of Public Health. 29:279-284
مصطلحات موضوعية: Male, Rural Population, Pediatrics, medicine.medical_specialty, Time Factors, Adolescent, Urban Population, Population, Poison control, Suicide prevention, Occupational safety and health, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Environmental health, Injury prevention, medicine, Humans, Child Abuse, 030212 general & internal medicine, Child, education, education.field_of_study, 030505 public health, Greece, business.industry, Data Collection, Incidence, Public health, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Human factors and ergonomics, General Medicine, Emergency department, Accidents, Child, Preschool, Population Surveillance, Wounds and Injuries, Female, Emergency Service, Hospital, 0305 other medical science, business
الوصف: Aim: It has been gradually recognized that intentional injuries among children represent a largely hidden problem in modern societies. With the exception of mortality, population-based data from Greece have not been previously reported. To assess the magnitude and the characteristics of intentional injuries among children aged 0-14 years old, data from the population-based Emergency Department Injury Surveillance System (EDISS) database during the period 1996-97 were used. Methods: EDISS relies on personal interviews with children and their escorts who contact the emergency departments of three hospitals. Two of these hospitals are district hospitals of the county of Magnesia and the island of Corfu, whereas the other is a university children's hospital that covers the Greater Athens area on alternative days. Results: Among 46,807 children recorded in EDISS, 108 injuries (0.23%) were attributed to acts of violence. Among the 108 intentional injuries, only 11 were caused by firearms or other weapons and only 4 concerned infants. In comparison to unintentional home and leisure injuries, intentional childhood injuries increase significantly with age and they are more common among migrant children. They occur more frequently during late night and early morning hours, they are more serious, and they are more often multiple and concentrated on the head. Conclusions : In Greece, a problem of violence directed against children does exist. The actual magnitude of this problem is difficult to estimate, but its size appears to be smaller in comparison with that reported in other populations.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21de3bdbb2faa2ebf5ba103eaf8a01e6Test
https://doi.org/10.1177/14034948010290041301Test -
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المصدر: Pediatric Infectious Disease Journal. 28:250-252
مصطلحات موضوعية: Male, Microbiology (medical), medicine.medical_specialty, Adolescent, computer.internet_protocol, Herpesvirus 6, Human, Papular purpuric gloves and socks syndrome, Erythema Infectiosum, Hand Dermatoses, Exanthema Subitum, Antibodies, Viral, Hand Dermatosis, parasitic diseases, Parvovirus B19, Human, medicine, Humans, Child, Purpura, Foot Dermatoses, business.industry, Syndrome, equipment and supplies, medicine.disease, Dermatology, Surgery, Infectious Diseases, SOCKS, El Niño, Pediatrics, Perinatology and Child Health, Coinfection, Female, medicine.symptom, business, computer
الوصف: We describe the case of a 12-year-old boy with gloves and socks syndrome caused by coinfection with HHV-6 and PVB19, and review the published cases from 5 to 18 years of age to profile the disease in this age group. The review of the literature yielded 25 cases of gloves and socks syndrome. Most patients were febrile and had acute PVB19 infection.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5db40e5877a00c7f0a34a8c7eeb51eTest
https://doi.org/10.1097/inf.0b013e31818cb289Test -
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المؤلفون: Maria Tsolia, John Mathioudakis, Themistokles Karpathios, Maria Moustaki, Andrew Fretzayas, Polyxeni Nicolaidou, Emmanuel Kavazarakis, Olga Grafakou
المصدر: Pediatric pulmonology. 38(6)
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Male, medicine.medical_specialty, Time Factors, Adolescent, Fever, Pleural effusion, macromolecular substances, Severity of Illness Index, Community-acquired pneumonia, Predictive Value of Tests, Internal medicine, Severity of illness, medicine, Humans, Child, Lung, Retrospective Studies, Univariate analysis, business.industry, Respiratory disease, Infant, Odds ratio, Pneumonia, Length of Stay, medicine.disease, Prognosis, respiratory tract diseases, Surgery, Anti-Bacterial Agents, Pleural Effusion, Radiography, Pleurisy, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business
الوصف: Predictors of the severity of pneumonia have not been thoroughly evaluated among children in developed countries. We investigate whether chest radiographic findings could be used as predictors of severity of childhood pneumonia. The study included 167 children, aged more than 12 months, hospitalized in our department during a 4-year period with unilateral lobar or segmental pneumonia. The durations of fever and of hospitalization were considered indicators of severity of the disease. The size of the consolidation and its location in the left hemithorax were independently associated with severity of the disease. Univariate analysis showed that the mean duration of fever and of hospitalization as well as the prevalence of pleural effusion was significantly higher among children with left-sided pneumonia. A multiple logistic regression analysis revealed that only the presence of pleural effusion was significantly more likely in left-sided pneumonia (odds ratio, 2.65; 95% confidence interval, 1.09-6.47; P = 0.031). We conclude that the size of consolidation and the side of its location can be used as predictors of severity of pneumonia, with left-sided pneumonia running a more severe course, possibly due to increased risk for the development of pleurisy.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c15846c6b0cb38a7bf87dbe29743fabTest
https://pubmed.ncbi.nlm.nih.gov/15481079Test -
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المؤلفون: Dimitrios Trichopoulos, Christos S. Mantzoros, Eleni Petridou, Nick Dessypris, Alkistis Skalkidou, Evagelos Spanos, Maria Moustaki
المصدر: Oncology. 60(3)
مصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Childhood leukemia, Adolescent, medicine.medical_treatment, Hepatosplenomegaly, Insulin-like growth factor-binding protein, Insulin-like growth factor, Insulin-Like Growth Factor II, Internal medicine, medicine, Humans, Insulin-Like Growth Factor I, Child, Survival analysis, biology, business.industry, Growth factor, Infant, Newborn, Infant, General Medicine, Precursor Cell Lymphoblastic Leukemia-Lymphoma, medicine.disease, Leukemia, Endocrinology, Insulin-Like Growth Factor Binding Protein 3, Oncology, El Niño, Child, Preschool, biology.protein, Female, medicine.symptom, business
الوصف: Objective: To investigate whether the three principal components of the insulin-like growth factor (IGF) system, IGF-1, IGF-2 and IGF binding protein-3 (IGFBP-3), are associated with survival from childhood leukemia. Patients and Methods: 116 children, 0–14 years old, with newly diagnosed and bone-marrow-biopsy-confirmed acute childhood leukemia between 1993 and 1996 were followed up until death or March 31, 1998. IGF-1, IGF-2 and IGFBP-3 were measured at diagnosis and clinical data, including presence of hepatosplenomegaly and number of white blood cells, were available. Results: After controlling for gender, age, indicators of clinical severity and the other measured components of the IGF system there was a statistically significant (p < 0.05) inverse association of IGFBP-3 with survival. An increment of one standard deviation in IGFBP-3 was associated with a 65% reduction of the death hazard among the children with leukemia. Neither IGF-1 nor IGF-2 was associated with survival in this data set. Conclusion: The presented empirical evidence in conjunction with the fact that IGFBP-3 modulates IGF-1 and IGF-2 bioavailability and is likely to have proapoptotic effects makes this compound a plausible independent predictor of survival from childhood leukemia.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6aaae2b77ea4a315f8e713df243d33Test
https://pubmed.ncbi.nlm.nih.gov/11340377Test
