المؤلفون: Reinhard Dummer, Georgina V. Long, Caroline Robert, Hussein A. Tawbi, Keith T. Flaherty, Paolo A. Ascierto, Paul D. Nathan, Piotr Rutkowski, Oleg Leonov, Caroline Dutriaux, Mario Mandalà, Paul Lorigan, Pier Francesco Ferrucci, Jean Jacques Grob, Nicolas Meyer, Helen Gogas, Daniil Stroyakovskiy, Ana Arance, Jan C. Brase, Steven Green, Tomas Haas, Aisha Masood, Eduard Gasal, Antoni Ribas, Dirk Schadendorf

المساهمون: University of Zurich

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 40, iss 13
Dummer, R, Long, G V, Robert, C, Tawbi, H A, Flaherty, K T, Ascierto, P A, Nathan, P D, Rutkowski, P, Leonov, O, Dutriaux, C, Mandalà, M, Lorigan, P, Ferrucci, P F, Grob, J J, Meyer, N, Gogas, H, Stroyakovskiy, D, Arance, A, Brase, J C, Green, S, Haas, T, Masood, A, Gasal, E, Ribas, A & Schadendorf, D 2022, ' Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600-Mutant Unresectable or Metastatic Melanoma ', Journal of clinical oncology : official journal of the American Society of Clinical Oncology . https://doi.org/10.1200/JCO.21.01601Test

مصطلحات موضوعية: Proto-Oncogene Proteins B-raf, Adult, Cancer Research, Skin Neoplasms, Adolescent, Pyridones, Clinical Trials and Supportive Activities, Clinical Sciences, Oncology and Carcinogenesis, Medizin, 610 Medicine & health, Pyrimidinones, Antibodies, Death Domain, Clinical Research, Neoplasms, Oximes, Antineoplastic Combined Chemotherapy Protocols, Receptors, Monoclonal, Genetics, Humans, Oncology & Carcinogenesis, Melanoma, Humanized, Cancer, Manchester Cancer Research Centre, ResearchInstitutes_Networks_Beacons/mcrc, Human Genome, Imidazoles, Evaluation of treatments and therapeutic interventions, 10177 Dermatology Clinic, Second Primary, Oncology, 6.1 Pharmaceuticals, Mutation

وصف الملف: 928_Dummer_R._et_al._Randomized_Phase_III_Trial_Evaluationg_Spartalizumab_plus_Dabrafenib_and_Trametinib_for_BRAF_V600_mutant_JCO_2022.pdf - application/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512e67c5f66bacf61087d7e838e0dc59Test
https://www.zora.uzh.ch/id/eprint/213526Test/

المؤلفون: Reinhard, Dummer, Jan C, Brase, James, Garrett, Catarina D, Campbell, Eduard, Gasal, Matthew, Squires, Daniel, Gusenleitner, Mario, Santinami, Victoria, Atkinson, Mario, Mandalà, Vanna, Chiarion-Sileni, Keith, Flaherty, James, Larkin, Caroline, Robert, Richard, Kefford, John M, Kirkwood, Axel, Hauschild, Dirk, Schadendorf, Georgina V, Long

المصدر: The Lancet. Oncology. 21(3)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, Skin Neoplasms, Adolescent, Pyridones, Pyrimidinones, Young Adult, Double-Blind Method, Antineoplastic Combined Chemotherapy Protocols, Oximes, Humans, Neoplasm Metastasis, Melanoma, Aged, Aged, 80 and over, Salvage Therapy, Imidazoles, Middle Aged, Prognosis, Survival Rate, Drug Resistance, Neoplasm, Mutation, Female, Neoplasm Recurrence, Local, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::82f686582204c03888e4020dc478c975Test
https://pubmed.ncbi.nlm.nih.gov/32007137Test

المؤلفون: Vanna Chiarion-Sileni, M. Mandal, A. Hauschild, Bijoyesh Mookerjee, R. Ji, Jeffrey J. Legos, John M. Kirkwood, Victoria Atkinson, Jacob Schachter, James Larkin, Richard F. Kefford, Ping Zhang, Caroline Robert, Caroline Dutriaux, M. Santinami, Andrew Haydon, Dirk Schadendorf, Georgina V. Long, Thierry Lesimple, Reinhard Dummer, Laurent Mortier, Marta Nyakas, Ruth Plummer

المساهمون: University of Zurich, Long, Georgina V

المصدر: New England Journal of Medicine. 377:1813-1823

مصطلحات موضوعية: Male, 0301 basic medicine, Oncology, Skin Neoplasms, Medizin, 2700 General Medicine, 0302 clinical medicine, Antineoplastic Combined Chemotherapy Protocols, Oximes, Clinical endpoint, Melanoma, Aged, 80 and over, Trametinib, MEK inhibitor, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Combination therapy, Pyridones, 610 Medicine & health, Pyrimidinones, Young Adult, 03 medical and health sciences, Adjuvants, Immunologic, Double-Blind Method, Internal medicine, medicine, Humans, Survival analysis, Aged, Neoplasm Staging, business.industry, Dabrafenib, medicine.disease, Survival Analysis, Surgery, Clinical trial, 030104 developmental biology, Mutation, Neoplasm Recurrence, Local, business

وصف الملف: 720_Long_GV._et_al._Adjuvant_Dabrafenib_plus_Trametinib_in_Stage_III_NEJM_2017.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20521edecf000680510735bacb9ee32Test
https://doi.org/10.1056/nejmoa1708539Test

المؤلفون: Christian U. Blank, Adil Daud, Rene Gonzalez, Kim Margolin, Scot Ebbinghaus, Ziwen Wei, Dirk Schadendorf, Antoni Ribas, Anna C. Pavlick, Lee D. Cranmer, Caroline Robert, April K.S. Salama, Jacob Schachter, Omid Hamid, Reinhard Dummer, Nageatte Ibrahim, F. Stephen Hodi, Igor Puzanov, Tara C. Gangadhar, Paolo A. Ascierto

المساهمون: University of Zurich, Hamid, Omid

مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, Skin Neoplasms, Time Factors, medicine.medical_treatment, Medizin, Phases of clinical research, Pembrolizumab, Kaplan-Meier Estimate, 0302 clinical medicine, Antineoplastic Agents, Immunological, 1306 Cancer Research, Melanoma, Aged, 80 and over, education.field_of_study, Cross-Over Studies, Drug Substitution, Hazard ratio, 10177 Dermatology Clinic, Middle Aged, MAP Kinase Kinase Kinases, Treatment Outcome, 030220 oncology & carcinogenesis, Disease Progression, 2730 Oncology, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Population, Ipilimumab, 610 Medicine & health, Antibodies, Monoclonal, Humanized, Disease-Free Survival, 03 medical and health sciences, Young Adult, Internal medicine, medicine, Humans, education, Protein Kinase Inhibitors, Aged, Chemotherapy, business.industry, medicine.disease, Confidence interval, Surgery, 030104 developmental biology, Drug Resistance, Neoplasm, Mutation, business

وصف الملف: 721_Hamid_O._et_al._Final_analysis_of_randomised_trial_comparing_pembrolizumab_versus_Eur_J_Cancer_2017.pdf - application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab24a3779538f584d0432f320113cbb5Test
https://www.ncbi.nlm.nih.gov/pubmed/28961465Test

المؤلفون: Caroline Robert, Piotr Rutkowski, Arkadiusz Jeziorski, Alexander M.M. Eggermont, Nyam Kamsu-Kom, Wanda Michej, Monika Jurkowska, Senada Koljenović, Hanna Koseła-Paterczyk, Piotr Pluta, Aleksandra Gos, Alexander C.J. van Akkooi, Cornelis Verhoef, Janusz A. Siedlecki

المساهمون: Surgery, Pathology

المصدر: Annals of Surgical Oncology, 21(13), 4317-4323. Springer New York
Annals of Surgical Oncology

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Oncology, Adult, Male, Proto-Oncogene Proteins B-raf, Melanomas, medicine.medical_specialty, Pathology, Adolescent, Clinical manifestation, GTP Phosphohydrolases, Young Adult, Surgical oncology, Internal medicine, medicine, Biomarkers, Tumor, Humans, Child, Melanoma, neoplasms, Neoplasm Staging, business.industry, Infant, Newborn, Infant, Membrane Proteins, Middle Aged, medicine.disease, Prognosis, Survival Rate, Proto-Oncogene Proteins c-kit, Child, Preschool, Lymphatic Metastasis, Mutation, Unknown primary, Lymph Node Excision, Neoplasms, Unknown Primary, Female, Surgery, business, NODAL, Follow-Up Studies

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c513b3121a04b568fd11b247eb12e701Test
https://pure.eur.nl/en/publications/401407dc-0d30-433c-a98b-21c7791c25a1Test

المؤلفون: Céleste Lebbé, Anna Maria Di Giacomo, Helen Gogas, Georgina V. Long, Paolo A. Ascierto, Catalin Mihalcioiu, Francesco Cognetti, Ewa Kalinka-Warzocha, Kerry J. Savage, Cornelia Mauch, Ana Arance, Jasmine I. Rizzo, Lars Ny, Caroline Dutriaux, Piotr Rutkowski, Caroline Robert, Micaela Hernberg, Victoria Atkinson, Vanna Chiarion-Sileni, Benjamin Brady, Inge Marie Svane, Dirk Schadendorf, Jessica C. Hassel, Julie Charles, Laurent Mortier, Catriona M. McNeil, Abdel Saci, Joel Jiang

المصدر: JAMA Oncol

مصطلحات موضوعية: advanced melanoma, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, medicine.medical_specialty, Skin Neoplasms, Time Factors, Adolescent, Dacarbazine, Medizin, Phases of clinical research, Ipilimumab, Pembrolizumab, Placebo, BRAF, Young Adult, 03 medical and health sciences, Antineoplastic Agents, Immunological, 0302 clinical medicine, Double-Blind Method, Internal medicine, medicine, Humans, 030212 general & internal medicine, Nivolumab, wild-type, Antineoplastic Agents, Alkylating, Melanoma, Aged, Aged, 80 and over, business.industry, Hazard ratio, Correction, Middle Aged, medicine.disease, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Female, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c9b0d0b1e4e0e7e07096a725b4e567Test
https://doi.org/10.1001/jamaoncol.2018.4514Test

المؤلفون: Pascal Wolter, Dirk Schadendorf, Daniil Stroiakovski, Michael Lichinitser, Jeff Legos, Paul Nathan, Peng Sun, Kamil Drucis, Keith T. Flaherty, Boguslawa Karaszewska, Antoni Ribas, Florent Grange, Anne-Marie Martin, Shonda M Little, Reinhard Dummer, Ivana Krajsová, Laurent Mortier, Vanna Chiarion-Sileni, Wendy A. Crist, Paul Lorigan, Stephen D. Rubin, Andrzej Mackiewicz, Piotr Rutkowski, Jacob Schachter, Caroline Robert, Georgina V. Long, Axel Hauschild

المساهمون: University of Zurich, Robert, Caroline

مصطلحات موضوعية: Oncology, Male, Keratoacanthoma, Indoles, Skin Neoplasms, Medizin, Kaplan-Meier Estimate, 2700 General Medicine, chemistry.chemical_compound, Antineoplastic Combined Chemotherapy Protocols, Oximes, Vemurafenib, Melanoma, Trametinib, Aged, 80 and over, education.field_of_study, Sulfonamides, Hazard ratio, Imidazoles, 10177 Dermatology Clinic, General Medicine, Middle Aged, Intention to Treat Analysis, Female, medicine.drug, Adult, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Pyridones, Population, 610 Medicine & health, Pyrimidinones, Young Adult, Internal medicine, medicine, Humans, education, neoplasms, Protein Kinase Inhibitors, Aged, Cobimetinib, Mitogen-Activated Protein Kinase Kinases, business.industry, Dabrafenib, medicine.disease, Survival Analysis, Surgery, chemistry, Mutation, business

وصف الملف: Robert C et al. - N Engl J Med 2014.pdf - application/pdf; Print-Electronic; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb174f02e29f4375b8bd8c23ddb74764Test
https://doi.org/10.5167/uzh-107163Test

المؤلفون: Victoria Atkinson, Céleste Lebbé, Jessica C. Hassel, Catalin Mihalcioiu, Cornelia Mauch, Ewa Kalinka-Warzocha, Ian M. Waxman, Ana Arance, Piotr Rutkowski, Kerry J. Savage, Vanna Chiarion-Sileni, Caroline Dutriaux, Micaela Hernberg, Abstr Act, Laurent Mortier, Catriona M. McNeil, Brian Sharkey, Caroline Robert, Dirk Schadendorf, Michele Maio, Christine Horak, Georgina V. Long, Lotta Lundgren-Eriksson, Benjamin Brady, Helen Gogas, Francesco Cognetti, Henrik Schmidt, Paolo A. Ascierto, Julie Charles

المصدر: Robert, C, Long, G V, Brady, B, Dutriaux, C, Maio, M, Mortier, L, Hassel, J C, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Savage, K J, Hernberg, M M, Lebbé, C, Charles, J, Mihalcioiu, C, Chiarion-Sileni, V, Mauch, C, Cognetti, F, Arance, A, Schmidt, H, Schadendorf, D, Gogas, H, Lundgren-Eriksson, L, Horak, C, Sharkey, B, Waxman, I M, Atkinson, V & Ascierto, P A 2015, ' Nivolumab in previously untreated melanoma without BRAF mutation ', The New England Journal of Medicine, vol. 372, no. 4, pp. 320-30 . https://doi.org/10.1056/NEJMoa1412082Test
New England Journal of Medicine; 372(4), pp 320-330 (2015)

مصطلحات موضوعية: Adult, Male, Proto-Oncogene Proteins B-raf, medicine.medical_specialty, Adolescent, Dacarbazine, Programmed Cell Death 1 Receptor, Medizin, Phases of clinical research, Ipilimumab, Antineoplastic Agents, Pembrolizumab, ipilimumab-refractory metastatic melanoma, Gastroenterology, Disease-Free Survival, Young Adult, Double-Blind Method, Nivolumab, melanoma, ipilimumab-refractory metastatic melanoma, Internal medicine, Medicine, Humans, Survival rate, Melanoma, Aged, Aged, 80 and over, business.industry, Hazard ratio, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, Surgery, Survival Rate, Nivolumab, Cancer and Oncology, Female, business, medicine.drug

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07253c758028e0b62a420832a391b6ecTest
https://pubmed.ncbi.nlm.nih.gov/25511188Test

المؤلفون: Sabine Druillennec, Alain Spatz, Vladimir Lazar, Philippe Dessen, Joost van den Oord, Caroline Robert, Brigitte Bressac-de Paillerets, Caroline Kannengiesser, Stefan Michiels, Alain Sarasin, Fabienne Lesueur, V. Winnepenninckx, Alain Eychène

المصدر: Molecular oncology. 1(4)

مصطلحات موضوعية: Neuroblastoma RAS viral oncogene homolog, Adult, Male, Proto-Oncogene Proteins B-raf, Cancer Research, Skin Neoplasms, Adolescent, Ultraviolet Rays, DNA Mutational Analysis, Mutation, Missense, Biology, medicine.disease_cause, Young Adult, Cell Movement, Gene expression, Genetics, medicine, Humans, Child, neoplasms, Melanoma, Aged, Regulation of gene expression, Aged, 80 and over, Mutation, Melanosomes, Gene Expression Profiling, Immunity, Infant, General Medicine, Middle Aged, medicine.disease, Microphthalmia-associated transcription factor, Molecular biology, digestive system diseases, Gene expression profiling, Gene Expression Regulation, Neoplastic, Genes, ras, Oncology, Child, Preschool, Cutaneous melanoma, Papers, Cancer research, Molecular Medicine, Female, DNA Probes

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aa656a369a59863ffb03c4699bc7235Test
https://pubmed.ncbi.nlm.nih.gov/19383316Test