دورية أكاديمية
Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel
| العنوان: | Topoisomerase-II alpha expression as a predictive marker in a population of advanced breast cancer patients randomly treated either with single-agent doxorubicin or single-agent docetaxel |
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| المؤلفون: | Durbecq, V, Paesmans, M, Cardoso, F, Desmedt, C, Di Leo, A, Chan, S, Friedrich, K, Pinter, T, Van Belle, S, Murray, E, Bodrogi, I, Walpole, E, Lesperance, B, Korec, S, Crown, J, Simmonds, P, Perren, TJ, Leroy, JY, Rouas, G, Sotiriou, C, Piccart, M, Larsimont, D |
| بيانات النشر: | AMER ASSOC CANCER RESEARCH |
| سنة النشر: | 2004 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Anthracycline-Based Therapy, Adjuvant Chemotherapy, P53, Amplification, Her2, Proliferation, Erbb-2, Overexpression, Efficacy |
| الوصف: | Purpose: The predictive value of topoisomerase-IIalpha (topo-II) has been evaluated in advanced breast cancer patients randomly treated with single-agent doxorubicin or docetaxel. Experimental design: Primary tumor samples from patients enrolled in a randomized, phase III clinical trial comparing single-agent doxorubicin (75 mg/m(2) q3wks) with docetaxel (100 mg/m(2) q3wks) were collected and topo-II status was evaluated by immunohistochemistry (clone KiS1). Results: Topo-II status was evaluated in 108 samples, 55 (51%) in the doxorubicin arm and 53 (49%) in the docetaxel arm. An increment of 10% in cells expressing topo-II is associated with a statistically significant odds ratio (OR; 95% confidence interval) of 1.09 (1.03 - 1.15; P = 0.002) for overall response to doxorubicin versus 1.002 (0.94 - 1.07; P = 0.95) in the docetaxel arm. With increasing topo-II, the favorable OR for overall response to docetaxel compared with doxorubicin decreases to become not significant in patients with topo-II tumor content > 10%. In a multivariate analysis, (a) HER-2 status seems positively correlated with overall response to chemotherapy (OR, 2.34; 95% confidence interval, 0.87 - 6.27; P = 0.09). (b) Overall response to doxorubicin is significantly lower than overall response to docetaxel (OR, 0.17; 95% confidence interval, 0.040 - .64; P = 0.009) but with a significant interaction term for doxorubicin-treated patients with topo-II tumor content > 10% (OR, 8.31; 95% confidence interval, 1.86 - 37.03; P = 0.05). Conclusions: (a) Topo-II overexpression confers a higher probability of response in the doxorubicin arm only. (b) Despite being a small retrospective study, this study is in line with previously reported studies and the hypotheses raised are now being tested in a prospective neoadjuvant trial. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1535-7163 |
| العلاقة: | orcid:0000-0001-6105-9039 |
| الإتاحة: | https://doi.org/10.1023/B:BREA.0000036783.88387.47Test https://espace.library.uq.edu.au/view/UQ:589433Test |
| رقم الانضمام: | edsbas.E77B105D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15357163 |
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