التفاصيل البيبلوغرافية
| العنوان: |
Association of Abdominal Adiposity, Inflammation Markers and Cardiac Valve Calcifications in Haemodialysis Patients. |
| المؤلفون: |
Spahia, Nereida, Rroji, Merita, Seferi, Saimir, Idrizi, Alma, Rista, Elvana, Barbullushi, Myftar, Petrela, Elizana, Thereska, Nestor |
| المصدر: |
BANTAO Journal; 2012, Vol. 10 Issue 2, p74-77, 4p |
| مصطلحات موضوعية: |
ABDOMINAL diseases, ABDOMINAL angina, OBESITY, NUTRITION disorders, HEART valves |
| مستخلص: |
Introduction. Valve calcification is highly prevalent and an important predictor for all cause mortality in haemodialysis (HD) patients. Abdominal fat deposition is linked to inflammation and protein-energy wasting and it is also associated with increased mortality risk. An association of inflammation and malnutrition with cardiac VC is reported, similar to that of atherosclerosis. We evaluated the possible relationship between abdominal fat deposition, inflammation markers and valve calcification (VC) in patients on maintenance haemodialysis (HD). Methods. The data of 69 haemodialysis patients were analysed. There were 41 (59.4%) males, mean age 51.39± 12.72 yrs and mean time on therapy 54.3±39.9 months. The presence of cardiac valve calcification was assessed by standard bi-dimensional echocardiography. Abdominal fat deposition was assessed by conicity index (Ci). Fibrinogen and C-reactive protein (CRP) were measured to assess the presence of inflammation. Results. The prevalence of valve calcification was 58%. Significantly higher fibrinogen level [446±100.84 vs 356 ±109.01 (p=0.037)], conicity index [1.45±0.13 vs 1.33±0.08 (p= 0.002)] and lower s-albumin (3.8±0.32 vs 4.04±0.29 (p=0.045)] were observed in the group with valve calcification compared to the group without valve calcification. Patients were divided into groups according to tertiles of Ci distribution. There were statistically significant differences in fibrinogen, VC and BMI between Ci groups, with significantly higher fibrinogen (p= 0.001), valve calcification (p=0.01) and BMI (p=0.043) in high Ci group. Significant difference between Ci groups was found for CRP. A significant relationship between presence of valve calcification with Ci and fibrinogen and inversely with serum albumin was found [(r= 0.414, p= 0.002); (r=0.224, p= 0.043); (r= -0.274, p= 0.045) respectively]. Conclusions. We found that abdominal adiposity was frequent in HD patients, and it was associated with inflammatory markers, both being risk factors for heart valve calcification. HD patients must be encouraged to decrease the abdominal fat, even when they are not overweight. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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