Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years
| العنوان: | Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years |
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| المؤلفون: | Inge A.L.P. van Beijsterveldt, Pernille Neve Myers, Stuart G. Snowden, Ken K. Ong, Susanne Brix, Anita C.S. Hokken-Koelega, Albert Koulman |
| المساهمون: | Pediatrics, Ong, Kenneth [0000-0003-4689-7530], Koulman, Albert [0000-0001-9998-051X], Apollo - University of Cambridge Repository |
| المصدر: | van Beijsterveldt, I A L P, Myers, P N, Snowden, S G, Ong, K K, Brix, S, Hokken-Koelega, A C S & Koulman, A 2022, ' Distinct infant feeding type-specific plasma metabolites at age 3 months associate with body composition at 2 years ', Clinical Nutrition, vol. 41, no. 6, pp. 1290-1296 . https://doi.org/10.1016/j.clnu.2022.04.015Test Clinical Nutrition, 41(6), 1290-1296. Churchill Livingstone |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Nutrition and Dietetics, Breastfeeding, Infant, Intra-Abdominal Fat, Critical Care and Intensive Care Medicine, Body composition, Breast Feeding, Child, Preschool, Body Composition, Humans, Metabolomics, Female, Obesity, Breasfeeding, Adiposity |
| الوصف: | Background and Objectives: Early life is a critical window for adiposity programming and metabolic profile may affect this programming. We investigated if plasma metabolites at age 3 months were associated with fat mass, fat free mass and abdominal subcutaneous and visceral fat outcomes at age 2 years in a cohort of healthy infants and if these associations were different between infants receiving exclusive breastfeeding (EBF) and those with exclusive formula feeding (EFF). Methods: In 318 healthy term-born infants, we determined body composition by Dual Energy X-ray absorptiometry (DXA) and visceral fat by abdominal ultrasound at 2 age years. High-throughput metabolic profiling was performed on blood samples collected at age 3 months. Tertiles were generated for each body composition outcome and differences in plasma metabolite levels at age 3 months between infants with high and low body composition outcomes at age 2 years were evaluated in general, as well as separately in EBF- and EFF-infants. Results: Distinct plasma metabolite variables identified at age 3 months were associated with body composition at 2 years. These metabolites included several classes of lyso-phospholipids. Associations between the metabolites at age 3 months and fat mass index, fat mass percentage, fat free mass index and visceral fat at 2 years were predominantly found in EBF-infants. Conclusion: Associations between plasma metabolite levels at age 3 months and high body fat mass at 2 years depend on infant feeding type. These findings contribute to our insight into the importance of infant feeding on adiposity programming in early life. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 0261-5614 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1dd84d0532f33ae1b7192ef39e85da2Test https://orbit.dtu.dk/en/publications/d5ef8338-d69c-45fb-855f-dc7fd61ff173Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1dd84d0532f33ae1b7192ef39e85da2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02615614 |
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