دورية أكاديمية
The adipose tissue of origin influences the biological potential of human adipose stromal cells isolated from mediastinal and subcutaneous fat depots
| العنوان: | The adipose tissue of origin influences the biological potential of human adipose stromal cells isolated from mediastinal and subcutaneous fat depots |
|---|---|
| المؤلفون: | SICILIANO, CAMILLA, BORDIN, ANTONELLA, IBRAHIM, MOHSEN, CHIMENTI, ISOTTA, CASSIANO, FRANCESCO, GATTO, ILENIA, MANGINO, GIORGIO, COCCIA, ANDREA, MIGLIETTA, SELENIA, BASTIANELLI, DANIELA, PETROZZA, Vincenzo, CALOGERO, ANTONELLA, FRATI, GIACOMO, DE FALCO, ELENA |
| المساهمون: | Siciliano, Camilla, Bordin, Antonella, Ibrahim, Mohsen, Chimenti, Isotta, Cassiano, Francesco, Gatto, Ilenia, Mangino, Giorgio, Coccia, Andrea, Miglietta, Selenia, Bastianelli, Daniela, Petrozza, Vincenzo, Calogero, Antonella, Frati, Giacomo, DE FALCO, Elena |
| بيانات النشر: | Elsevier Amsterdam |
| سنة النشر: | 2016 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | mesenchymal stem cell, adipose tissue, platelet lysate angiogenesi, transmission electron microscopy |
| الوصف: | Indirect evidence suggests that adipose tissue-derived stromal cells (ASCs) possess different physiological and biological variations related to the anatomical localization of the adipose depots. Accordingly, to investigate the influence of the tissue origin on the intrinsic properties of ASCs and to assess their response to specific stimuli, we compared the biological, functional and ultrastructural properties of two ASC pools derived from mediastinal and subcutaneous depots (thoracic compartment) by means of supplements such as platelet lysate (PL) and FBS. Subcutaneous ASCs exhibited higher proliferative and clonogenic abilities than mediastinal counterpart, as well as increased secreted levels of IL-6 combined with lower amount of VEGF-C. In contrast, mediastinal ASCs displayed enhanced pro-angiogenic and adipogenic differentiation properties, increased cell diameter and early autophagic processes, highlighted by electron microscopy. Our results further support the hypothesis that the origin of adipose tissue significantly defines the biological properties of ASCs, and that a homogeneric function for all ASCs cannot be assumed. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/27614132; info:eu-repo/semantics/altIdentifier/wos/WOS:000389523200020; volume:17; issue:2; firstpage:342; lastpage:351; numberofpages:10; journal:STEM CELL RESEARCH; http://hdl.handle.net/11573/878709Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84986000905; http://www.sciencedirect.com/science/article/pii/S1873506116300988Test |
| DOI: | 10.1016/j.scr.2016.07.010 |
| الإتاحة: | https://doi.org/10.1016/j.scr.2016.07.010Test http://hdl.handle.net/11573/878709Test http://www.sciencedirect.com/science/article/pii/S1873506116300988Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.785EFCBC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.scr.2016.07.010 |
|---|