Cancer metastases: challenges and opportunities
| العنوان: | Cancer metastases: challenges and opportunities |
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| المؤلفون: | Xiangming Guan |
| المصدر: | Acta Pharmaceutica Sinica. B Acta Pharmaceutica Sinica B, Vol 5, Iss 5, Pp 402-418 (2015) |
| بيانات النشر: | Elsevier BV, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | CA15-3, Pathology, HA, hyaluronan, JAK, the Janus kinases, Detachment, medicine.medical_treatment, Review, PDGF, platelet-derived growth factor, Metastasis, DISC, death-inducing signaling complex, Invasion, General Pharmacology, Toxicology and Pharmaceutics, FAs, focal adhesions, IKK, IκB kinase, VN, vitronectin, Migration, Cancer, TGF-β, transforming growth factor β, biology, TME, tumor microenvironment, PI3K, phosphatidylinositol 3-kinase, VCAMs, vascular cell adhesion molecules, VEGF, vascular endothelial growth factor, Primary tumor, ECM, extracellular matrix, CAT, collective amoeboid transition, CSF-1, chemokine colonystimulating factor–1, FAK, focal adhesion kinase, EGFR, EGF receptor, Adhesion, STATs, signal transducers and activators of transcription, EMT, epithelial–mesenchymal transition, Platelet-derived growth factor receptor, LN, laminin, medicine.medical_specialty, MAT, mesenchymal to amoeboid transition, MET, mesenchymal–epithelial transition, CTGF, connective tissue growth factor, Cancer stem cell, HIFs, hypoxia-inducible factors, TAMs, tumor-associated macrophages, medicine, CCR3, chemokine receptor 3, FN, fibronectin, EGF, epidermal growth factor, Tumor microenvironment, business.industry, lcsh:RM1-950, COX2, cyclooxygenase 2, CXCR2, chemokine receptor type 2, medicine.disease, Col, collagen, FGF, fibroblast growth factor, Radiation therapy, lcsh:Therapeutics. Pharmacology, BM, basement membrane, Cancer research, biology.protein, HGF, hepatocyte growth factor, MMPs, matrix metalloproteinases, CAMs, cell adhesion molecules, business, MAPK, mitogen-activated protein kinase, CAFs, cancer-associated fibroblasts, CCL2, chemokine (C–C motif) ligand 2 |
| الوصف: | Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Although cancer survival rate has been significantly improved over the years, the improvement is primarily due to early diagnosis and cancer growth inhibition. Limited progress has been made in the treatment of cancer metastasis due to various factors. Current treatments for cancer metastasis are mainly chemotherapy and radiotherapy, though the new generation anti-cancer drugs (predominantly neutralizing antibodies for growth factors and small molecule kinase inhibitors) do have the effects on cancer metastasis in addition to their effects on cancer growth. Cancer metastasis begins with detachment of metastatic cells from the primary tumor, travel of the cells to different sites through blood/lymphatic vessels, settlement and growth of the cells at a distal site. During the process, metastatic cells go through detachment, migration, invasion and adhesion. These four essential, metastatic steps are inter-related and affected by multi-biochemical events and parameters. Additionally, it is known that tumor microenvironment (such as extracellular matrix structure, growth factors, chemokines, matrix metalloproteinases) plays a significant role in cancer metastasis. The biochemical events and parameters involved in the metastatic process and tumor microenvironment have been targeted or can be potential targets for metastasis prevention and inhibition. This review provides an overview of these metastasis essential steps, related biochemical factors, and targets for intervention. Graphical abstract Cancer metastasis is the major cause of cancer morbidity and mortality, and accounts for about 90% of cancer deaths. Limited progress has been made in the treatment of cancer metastasis due to various factors. This review is aimed to provide an overview of the metastasis process and targets for intervention with a focus on cancer cell detachment, migration, invasion and adhesion. It is hoped that this review can serve as a lead for readers who are interested in cancer metastasis and intervention. |
| تدمد: | 2211-3835 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3f6f06ec2fa7a03c41137b4a13ce17Test https://doi.org/10.1016/j.apsb.2015.07.005Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....4b3f6f06ec2fa7a03c41137b4a13ce17 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22113835 |
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