التفاصيل البيبلوغرافية
| العنوان: |
Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer. |
| المؤلفون: |
Chutani, Namita, Ragula, Sandhya, Syed, Khajamohiddin, Pakala, Suresh B. |
| المصدر: |
Biomolecules (2218-273X); Oct2023, Vol. 13 Issue 10, p1527, 12p |
| مصطلحات موضوعية: |
TUMOR suppressor genes, CANCER cell growth, CANCER cell migration, CHROMATIN, ADENOSINE triphosphate, CARCINOGENS, MOLECULAR pathology, CELL migration inhibition |
| مستخلص: |
A newly discovered chromatin remodeler, MORC2, is a Microrchidia (MORC) family member. MORC2 acts as a chromatin remodeler by binding to the DNA and changing chromatin conformation using its ATPase domain. MORC2 is highly expressed in a variety of human cancers. It controls diverse signaling pathways essential for cancer development through its target genes and interacting partners. MORC2 promotes cancer cells' growth, invasion, and migration by regulating the expression of genes involved in these processes. MORC2 is localized primarily in the nucleus and is also found in the cytoplasm. In the cytoplasm, MORC2 interacts with adenosine triphosphate (ATP)-citrate lyase (ACLY) to promote lipogenesis and cholesterogenesis in cancer. In the nucleus, MORC2 interacts with the transcription factor c-Myc to control the transcription of genes involved in glucose metabolism to drive cancer cell migration and invasion. Furthermore, MORC2 recruits on to the promoters of tumor suppressor genes to repress their transcription and expression to promote oncogenesis. In addition to its crucial function in oncogenesis, it plays a vital role in DNA repair. Overall, this review concisely summarizes the current knowledge about MORC2-regulated molecular pathways involved in cancer. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biomolecules (2218-273X) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder