Glucose Metabolism in NSCLC Is Histology-Specific and Diverges the Prognostic Potential of 18FDG-PET for Adenocarcinoma and Squamous Cell Carcinoma
| العنوان: | Glucose Metabolism in NSCLC Is Histology-Specific and Diverges the Prognostic Potential of 18FDG-PET for Adenocarcinoma and Squamous Cell Carcinoma |
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| المؤلفون: | Tineke W.H. Meijer, Johan Bussink, Johannes H.A.M. Kaanders, Erik H.F.M. van der Heijden, Monika G. Looijen-Salamon, Wim J.G. Oyen, Eric P. Visser, Paul N. Span, Miep A. van der Drift, Lioe-Fee de Geus-Oei, Olga C.J. Schuurbiers |
| المصدر: | Journal of Thoracic Oncology, 9, 10, pp. 1485-93 Journal of Thoracic Oncology, 9, 1485-93 |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Pathology, Lung Neoplasms, Cell, Muscle Proteins, Hypoxia-related markers, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Carbonic Anhydrases, Glucose Transporter Type 1, 18-Fluoro-2-deoxyglucose positron emission tomography, biology, Symporters, Middle Aged, Prognosis, Cell Hypoxia, 3. Good health, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], medicine.anatomical_structure, Real-time polymerase chain reaction, Monocarboxylate transporter 1, Oncology, Tumor microenvironment, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Adenocarcinoma, Female, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], Pulmonary and Respiratory Medicine, Monocarboxylic Acid Transporters, medicine.medical_specialty, Adenocarcinoma of Lung, Rare cancers Radboud Institute for Molecular Life Sciences [Radboudumc 9], Disease-Free Survival, 03 medical and health sciences, Antigens, Neoplasm, Fluorodeoxyglucose F18, medicine, Carcinoma, Humans, Carbonic Anhydrase IX, Aged, Neoplasm Staging, business.industry, Non–small-cell lung cancer, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Histology, medicine.disease, Tumor glucose metabolism, Glucose, Positron-Emission Tomography, biology.protein, GLUT1, Radiopharmaceuticals, business |
| الوصف: | Introduction Biological features of non–small-cell lung carcinomas (NSCLCs) are important determinants for prognosis. In this study, differences in glucose metabolism between adeno- and squamous cell NSCLCs were quantified using the hypoxia and glycolysis-related markers glucose transporter 1 (GLUT1), carbonic anhydrase IX (CAIX), monocarboxylate transporter 1 (MCT1) and 4 (MCT4) vasculature, and 18-fluoro-2-deoxyglucose ( 18 FDG)-uptake. Relevance of these markers for disease-free survival (DFS) was analyzed. Methods Patients with curatively resected stage I to II and resectable stage IIIA, cN0-1 adeno- or squamous cell NSCLC, of whom fresh-frozen lung resection biopsies and pretreatment 18 FDG-positron emission tomography (PET) scans were available, were included in this study ( n = 108). 18 FDG-uptake was quantified by calculating total lesion glycolysis (TLG). Metabolic marker expression was measured by immunofluorescent staining (protein) and quantitative polymerase chain reaction (messenger ribonucleic acid [mRNA]). Patients were retrospectively evaluated for DFS. Results mRNA and protein expression of metabolic markers, with the exception of MCT4, and TLG were higher in squamous cell carcinomas than in adenocarcinomas, whereas adenocarcinomas were better vascularized. Adenocarcinomas had a worse DFS compared with squamous cell carcinomas ( p = 0.016) based on the potential to metastasize. High TLG was associated with a worse DFS only in adenocarcinomas. Conclusion Our findings suggest that the adenocarcinomas exhibit glycolysis under normoxic conditions, whereas squamous cell carcinomas are exposed to diffusion-limited hypoxia resulting in a very high anaerobic glycolytic rate. Although squamous cell carcinomas have a higher 18 FDG-uptake, in general regarded as a poor prognostic factor, adenocarcinomas have a higher metastatic potential and a worse DFS. These findings show that 18 FDG-PET should be interpreted in relation to histology. This may improve the prognostic potential of 18 FDG-PET and may aid in exploiting 18 FDG-PET in treatment strategies allied to histology. |
| تدمد: | 1556-0864 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5eed41c598b0564cec9ac0cca5119dTest https://doi.org/10.1097/JTO.0000000000000286Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd5eed41c598b0564cec9ac0cca5119d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15560864 |
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