دورية أكاديمية
Utility of computed diffusion-weighted MRI for predicting aggressiveness of prostate cancer
| العنوان: | Utility of computed diffusion-weighted MRI for predicting aggressiveness of prostate cancer |
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| المؤلفون: | Waseda, Yuma, Yoshida, Soichiro, Takahara, Taro, Kwee, Thomas Christian, Matsuoka, Yoh, Saito, Kazutaka, Kihara, Kazunori, Fujii, Yasuhisa |
| المصدر: | Waseda , Y , Yoshida , S , Takahara , T , Kwee , T C , Matsuoka , Y , Saito , K , Kihara , K & Fujii , Y 2017 , ' Utility of computed diffusion-weighted MRI for predicting aggressiveness of prostate cancer ' , Journal of Magnetic Resonance Imaging , vol. 46 , no. 2 , pp. 490-496 . https://doi.org/10.1002/jmri.25593Test |
| سنة النشر: | 2017 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | biomarkers, diffusion magnetic resonance imaging, Gleason grading, multimodal imaging, prostatic neoplasms, MAGNETIC-RESONANCE, COEFFICIENT VALUES, RADICAL PROSTATECTOMY, TUMOR-DETECTION, 3 T, HISTOLOGIC GRADE, GLEASON SCORE, B VALUE, RATIO, ADC |
| الوصف: | PurposeTo investigate the value of computed (c) diffusion-weighted imaging (DWI) in assessing prostate cancer aggressiveness. Materials and MethodsFifty-five patients with peripheral zone prostate cancer who underwent prebiopsy 1.5T magnetic resonance imaging (including native DWI at b-values of 0 and 1000 s/mm(2)) were included. cDWI signal intensities of peripheral zone prostate cancer and nonmalignant prostate tissue were measured. Association between changes in monoexponentially calculated cDWI signals according to different b-values and primary Gleason grades were assessed. ResultsThe cDWI signal intensity of prostate cancer was lower at b=0 s/mm(2) and higher at b=1000 s/mm(2) compared to nonmalignant prostate tissue. The b-value at which the signal intensities of prostate cancer and nonmalignant prostate tissue were equal was defined as the iso-b-value. On multivariate analysis, only the iso-b-value was a significant predictor of primary Gleason grade 4/5 cancer (P=0.001). The area under the curve (AUC) of the iso-b-value for diagnosing primary Gleason grade 4/5 cancer was 0.94, and significantly higher than that of the tumor apparent diffusion coefficient (ADC) value with an AUC of 0.68 (P ConclusioncDWI with iso-b-value-based semiquantitative analysis was found to be useful for predicting the aggressiveness of prostate cancer and may potentially outperform tumor ADC measurements in this setting. Level of Evidence: 3 Technical Efficacy: Stage 2 J. MAGN. RESON. IMAGING 2017;46:490-496 |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://research.rug.nl/en/publications/bb3c39af-bbac-4278-a1f9-1fa0905264d7Test |
| DOI: | 10.1002/jmri.25593 |
| الإتاحة: | https://doi.org/10.1002/jmri.25593Test https://hdl.handle.net/11370/bb3c39af-bbac-4278-a1f9-1fa0905264d7Test https://research.rug.nl/en/publications/bb3c39af-bbac-4278-a1f9-1fa0905264d7Test https://pure.rug.nl/ws/files/47037813/Waseda_et_al_2017_Journal_of_Magnetic_Resonance_Imaging.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7705C878 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jmri.25593 |
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