التفاصيل البيبلوغرافية
العنوان:
Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases
المؤلفون:
Liping Yang , Shelby Umland , Peter Orth , Daniel Lundell , Luke Firmansjah , Feltz Robert , Chaoyang Dai , Joseph A. Kozlowski , Wensheng Yu , Janeta Popovici-Muller , Seong Heon Kim , Vincent S. Madison , John J. Piwinski , De-Yi Yang , M. Arshad Siddiqui , Ling Tong , Xiaoda Niu , Brian J. Lavey , Guowei Zhou , Banderpalle B. Shankar , Razia Rizvi , Kristin E. Rosner , Neng-Yang Shih , Aneta Kosinski , Hong Bian , Dansu Li , Vinay Girijavallabhan , Lei Chen , Himanshu Shah , Zhuyan Guo , Jing Sun , Wong Michael K C
المصدر:
Bioorganic & Medicinal Chemistry Letters . 20:7283-7287
بيانات النشر:
Elsevier BV, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
medicine.medical_treatment , Clinical Biochemistry , Anti-Inflammatory Agents , Pharmaceutical Science , Hydantoin , ADAM17 Protein , Pharmacology , Biochemistry , Arthritis, Rheumatoid , chemistry.chemical_compound , Dogs , Drug Discovery , medicine , Animals , Humans , Protease Inhibitors , Molecular Biology , Whole blood , chemistry.chemical_classification , biology , Acetylene , Organic Chemistry , Biological activity , Haplorhini , In vitro , Rats , ADAM Proteins , Cytokine , Enzyme , chemistry , Enzyme inhibitor , biology.protein , Molecular Medicine , Tumor necrosis factor alpha
الوصف:
Our research on hydantoin based TNF-α converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood. These studies led to the discovery of highly potent TACE inhibitors with good DMPK profiles.
تدمد:
0960-894X
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f13e3eb17b7abab77da7bd68ad794d7Test https://doi.org/10.1016/j.bmcl.2010.10.081Test
حقوق:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....1f13e3eb17b7abab77da7bd68ad794d7
قاعدة البيانات:
OpenAIRE
