The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells
| العنوان: | The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells |
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| المؤلفون: | Michael O׳Dwyer, Eva Szegezdi, Denis V. Baev, Janusz Krawczyk |
| المصدر: | Leukemia Research Reports, Vol 3, Iss 2, Pp 79-82 (2014) Leukemia Research Reports |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Acute myeloid leukemia, ABT-737, business.industry, CD34, Myeloid leukemia, Case Report, Hematology, Pharmacology, Putative leukemic stem cells, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Minimal residual disease, lcsh:RC254-282, 3. Good health, Haematopoiesis, Oncology, Cytarabine, Medicine, Cytotoxic T cell, Progenitor cell, Stem cell, business, medicine.drug, CD34+/CD38−, BH3-mimetic |
| الوصف: | The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations. This prompted us to test the BH3-mimetic compound ABT-737 for its ability to eradicate putative leukemic stem cells. ABT-737 demonstrated potent cytotoxic effects in all patient samples tested. The efficacy of ABT-737 against AML blasts and the primitive CD34+/CD38− population was equal and independent of sensitivity to cytarabine/daunorubicin. These results, together with previously reported synergistic effects of ABT-737 with chemotherapeutics make BH3-mimetics promising candidates for future AML treatment regimens. Highlights • ABT-737 potently kills AML blast cells. • ABT-737 has a cytotoxic effect against both bone marrow-derived AML blasts and putative Leukemic Stem cells (pLSCs). • ABT-737 has an equally high cytotoxic efficacy in disseminated AML putative Leukemic Stem cells (pLSCs). |
| اللغة: | English |
| تدمد: | 2213-0489 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b33d869bd4f179d9244c50488c4533fTest http://www.sciencedirect.com/science/article/pii/S2213048914000120Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3b33d869bd4f179d9244c50488c4533f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22130489 |
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