التفاصيل البيبلوغرافية
| العنوان: |
Endothelial Activation and Stress Index (EASIX) as an Early Predictor for Mortality and Overall Survival in Hematological and Non-Hematological Patients with COVID-19: Multicenter Cohort Study. |
| المؤلفون: |
Kalicińska, Elżbieta, Biernat, Monika, Rybka, Justyna, Zińczuk, Aleksander, Janocha-Litwin, Justyna, Rosiek-Biegus, Marta, Morawska, Marta, Waszczuk-Gajda, Anna, Drozd-Sokołowska, Joanna, Szukalski, Łukasz, Rymko, Marcin, Jabłonowska, Paula, Simon, Krzysztof, Wróbel, Tomasz |
| المصدر: |
Journal of Clinical Medicine; Oct2021, Vol. 10 Issue 19, p4373, 1p |
| مصطلحات موضوعية: |
COVID-19, OVERALL survival, ENDOTHELIUM diseases, HEMATOLOGIC malignancies, ACUTE kidney failure, COHORT analysis |
| مستخلص: |
COVID-19, as a disease involving the endothelium of multiple organs, is characterized by high mortality rates among hospitalized patients. Patients with hematological malignancies are particularly at risk of an unfavorable course of COVID-19. The endothelial activation and stress index (EASIX) score has been used as a simple predictor of overall survival (OS) in specific groups of hematological cancer patients. EASIX, as a biomarker of endothelial dysfunction, might play a prognostic role in patients with COVID-19. Here, we performed a comprehensive retrospective analysis of the EASIX score in 523 hospitalized COVID-19 patients with or without coexisting hematological cancer. Hematological cancer COVID-19 patients had higher EASIX scores compared to the overall population with COVID-19. In hematological patients, EASIX was a strong predictor of the occurrence of sepsis during COVID-19. Our findings demonstrated EASIX as a strong predictor of intensive care unit admission, in-hospital mortality, the occurrence of acute renal failure and the need for hemodialysis, both in hematological and non-hematological COVID-19 patients. Patients with a high EASIX score on COVID-19 diagnosis had significantly inferior OS compared to patients with low EASIX. We showed for the first time that EASIX might serve as a simple, universal prognostic tool of OS in both hematological and non-hematological COVID-19 patients. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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