المؤلفون: Kim, Sangkyu, Welsh, David A., Ravussin, Eric, Welsch, Michael A., Cherry, Katie E., Myers, Leann, Jazwinski, S. Michal

المساهمون: Tulane University Health Sciences Center, Louisiana State University Health Sciences Center, Pennington Biomedical Research Center, Louisiana State University

مصطلحات موضوعية: age, aging, energy metabolism, frailty, ageing, Activities of Daily Living, Adult, Aged, 80 and over, Basal Metabolism, Body Mass Index, Female, Humans, Male, Middle Aged, Muscle, Skeletal, Rest, Sarcopenia, Young Adult

الوصف: Previously, we showed that FI34, a frailty index based on 34 health and function ability variables, is heritable and a reliable phenotypic indicator of healthy aging. We have now examined the relationship between major components of energy expenditure and the FI34 in participants of the Louisiana Healthy Aging Study. Resting metabolic rate was associated with FI34, even after adjustment for fat-free mass, fat mass, age, sex, thyroid hormones, and insulin-like growth factor 1 levels, in multiple regression analyses. In contrast, there was no association between total daily energy expenditure and FI34. Circulating creatine phosphokinase, a clinical marker of muscle damage, was also significantly associated with FI34. However, these associations of resting metabolic rate with FI34 were restricted to the oldest old (≥90 years) and absent in younger age groups. In oldest old men, the association of FI34 with creatine phosphokinase persisted, whereas in the oldest old women, only the association with resting metabolic rate pertained with the appearance of an effect of body size and composition. These results point toward an increasing metabolic burden for the maintenance of homeodynamics as health declines in nonagenarians, and this has implications for contraction of metabolic reserve that may potentially accelerate the path to disability.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022095Test/; http://biomedgerontology.oxfordjournals.org/content/69/6/650.shortTest; Kim, S. et al (2014) 'An elevation of resting metabolic rate with declining health in nonagenarians may be associated with decreased muscle mass and function in women and men, respectively' J. Gerontol. A Biol. Sci. Med. Sci. 69 (6):650-6; http://hdl.handle.net/10547/594600Test; The journals of gerontology. Series A, Biological sciences and medical sciences; PMC4022095

الإتاحة: https://doi.org/10.1093/gerona/glt150Test
http://hdl.handle.net/10547/594600Test

المؤلفون: Credeur, Daniel P., Dobrosielski, Devon A., Arce-Esquivel, Arturo A., Welsch, Michael A.

المصدر: European Journal of Applied Physiology; Sep2009, Vol. 107 Issue 2, p219-225, 7p, 1 Black and White Photograph, 1 Diagram, 3 Charts, 2 Graphs

مصطلحات موضوعية: CARDIOVASCULAR system, ULTRASONIC imaging, BLOOD vessels, AGING, DEVELOPMENTAL biology, BLOOD circulation, BLOOD flow measurement, BLOOD pressure, COMPARATIVE studies, HEMODYNAMICS, RESEARCH methodology, MEDICAL cooperation, MOTOR ability, RESEARCH, RESEARCH funding, ACTIVITIES of daily living, EVALUATION research, ANATOMY, BRACHIAL artery, PHYSIOLOGY

مصطلحات جغرافية: UNITED States

مستخلص: The purpose of this study was to examine the flow velocity pattern of the brachial artery and to determine its relationship to measures of physical function. Subjects from the Louisiana Healthy Aging Study (n = 95; age = 84 +/- 10 years) were evaluated. Brachial artery flow velocities and dimensions were measured using high-resolution ultrasonography. The continuous scale of physical function and performance test (CS-PFP10) was used to assess physical function. This test is based on the performance of 11 activities of daily living. Total CS-PFP10 score was 39.51 +/- 21.21 U. Mean antegrade and retrograde velocities at rest were 14.2 +/- 4.7 and 3.6 +/- 2.2 cm/s, respectively. Ante-/retrograde ratio was 5.5 +/- 4.6. Brachial artery diameter was 4.3 +/- 0.7 mm. Pulse pressure and vascular conductance were 66 +/- 18 mmHg, and 0.9 +/- 0.5 ml/min/mmHg, respectively. Vascular conductance (r = -0.34), ante-/retrograde ratio (r = -0.42) and CS-PFP10 (r = -0.65) were inversely and retrograde velocity (r = 0.40) and pulse pressure (r = 0.36), were directly associated with age. Retrograde velocity was inversely related to vascular conductance (r = -0.27) and CS-PFP10 total score (r = -0.45). A MANOVA revealed that those with the higher CS-PFP10 scores had a lower retrograde velocity (P = 0.0001), but this association was, in part, age-dependent. Among nonagenarians (n = 52), those in the lower tertiles of the CS-PFP10 scores had significantly higher retrograde velocities compared to those in the higher tertiles (P = 0.035). These data indicate an increase in brachial retrograde velocity with age. These hemodynamic changes are related to a decline in physical function. [ABSTRACT FROM AUTHOR]

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المؤلفون: Welsch, Michael A.¹ mwelsch@lsu.edu, Dobrosielski, Devon A.¹, Arce-Esquivel, Arturo A.¹, Wood, Robert H.², Ravussin, Eric³, Rowley, Christina³, Jazwinski, S. Michal⁴

المصدر: Medicine & Science in Sports & Exercise. Jul2008, Vol. 40 Issue 7, p1237-1243. 7p. 3 Charts, 3 Graphs.

مصطلحات موضوعية: *ACTIVITIES of daily living, *BRACHIAL artery, *ARTERIAL dilatation, *CARDIOVASCULAR system, *OLDER people, *AGING, *PHYSICAL fitness, *SPORTS medicine, *SPORTS sciences

مستخلص: The article presents a study which examines the relation between brachial artery flow-mediated dilation (BAFMD) on individual and total scores on the physical functional performance (PFP-10) test in elderly subject. The results indicate significant relationships between vascular function, defined by BAFMD and individual items as well as the total scores achieved on the PFP-10. It notes that based on individual's PFP-10 total score, those in the highest functional class exhibited the highest BAFMD. Moreover, the results suggest that lower physical function may in part be the consequence of some pathology, injury or defect in peripheral vascular function, contributing to functional limitation and disability in aging population.