التفاصيل البيبلوغرافية
| العنوان: |
Optimal method for measuring tumor extent in needle biopsy specimens to identify small-volume prostate cancer. |
| المؤلفون: |
Kajikawa, Keishi, Kanao, Kent, Kobayashi, Ikuo, Nishikawa, Genya, Yoshizawa, Takahiko, Kato, Yoshiharu, Watanabe, Masahito, Zennami, Kenji, Nakamura, Kogenta, Sumitomo, Makoto |
| المصدر: |
International Journal of Urology; Jan2016, Vol. 23 Issue 1, p62-68, 7p |
| مصطلحات موضوعية: |
TUMORS, NEEDLE biopsy, PROSTATE cancer, PROSTATECTOMY, CANCER research, MULTIVARIATE analysis |
| مستخلص: |
Objectives To compare various methods for measuring tumor extent in prostate biopsy specimens to identify small-volume prostate cancer. Methods A total of 100 radical prostatectomy specimens were retrospectively analyzed. Receiver operating characteristic analysis was used to compare the abilities of prostate-specific antigen density, and four measures of tumor extent in prostate biopsy specimens - positive core number, greatest percentage of cancer in a single core, greatest length of cancer in cores and total length of cancer in cores - to identify small volume prostate cancer. Four definitions of insignificant cancer volume were used in this analysis: index and total tumor volume <0.5 mL, index tumor volume <1.3 mL and total tumor volume <2.5 mL. Multivariate analysis was also used to evaluate variables for predicting small-volume prostate cancer. Results Total length of cancer in cores had the highest areas under the curve of all the measures defining small-volume prostate cancer: index tumor volume <0.5 mL (0.855), total tumor volume <0.5 mL (0.877), index tumor volume <1.3 mL (0.784) and total tumor volume <2.5 mL (0.818). On multivariate analysis total length of cancer in cores was an independent predictive factor for prostate cancers with index tumor volume <0.5 mL ( P < 0.001), <1.3 mL ( P < 0.001) and total tumor volume <0.5 mL ( P < 0.001), respectively. Conclusion Our data suggest that total length of cancer in cores is the optimal measure of tumor extent in prostate biopsy specimens for identifying small-volume prostate cancer. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
