التفاصيل البيبلوغرافية
| العنوان: |
Topical Tirbanibulin, a Dual Src Kinase and Tubulin Polymerization Inhibitor, for the Treatment of Plaque-Type Psoriasis: Phase I Results. |
| المؤلفون: |
Hong, Jin-Bon, Wu, Po-Yuan, Qin, Albert, Huang, Yi-Wen, Tseng, Kuan-Chiao, Lai, Ching-Yu, Chan, Wing-Kai, Fang, Jane, Cutler, David L., Tsai, Tsen-Fang |
| المصدر: |
Pharmaceutics; Oct2022, Vol. 14 Issue 10, pN.PAG-N.PAG, 12p |
| مصطلحات موضوعية: |
FOUR day week, PSORIASIS, TUBULINS, ACTINIC keratosis, DISEASE relapse, POLYMERIZATION |
| مصطلحات جغرافية: |
TAIWAN |
| مستخلص: |
Plaque-type psoriasis is a common skin disorder. Tirbanibulin (KX01) is a new Src kinase inhibitor with potent antiproliferative activity against keratinocytes and has been approved for treatment of actinic keratosis. This Phase I study investigates the safety and activity of KX01 ointment in patients with plaque-type psoriasis. We recruited 28 patients from two medical centers in Taiwan. This study was performed in four stages. Double-blind treatments were randomized in stages I (KX01 0.01% + placebo, two rounds of two-week treatment) and II (KX01 0.1% + placebo, four weeks) and open-labelled in stages III (KX01 1%, five days) and IV (KX01 1%, five days weekly for four weeks). The safety, tolerability, KX01 concentration, target area score, physician global assessment, and disease relapse were determined. Most treatment-emergent adverse events were mild-to-moderate application site reactions. Three (50.0%) subjects from the stage IV group showed ≥50% reduction in the target area score (TAS50), while two subjects (33.3%) showed a clinically meaningful improvement in the physician global assessment score. KX01 0.01%, 0.1%, and 1% were safe and well-tolerated. KX01 1% at four weeks showed a promising activity for the treatment of plaque-type psoriasis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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