نتائج البحث - "ACh, acetylcholine"

المصدر: International Journal of Cardiology: Heart & Vasculature, Vol 31, Iss, Pp 100658-(2020)
International Journal of Cardiology. Heart & Vasculature

مصطلحات موضوعية: Ach, acetylcholine, medicine.medical_specialty, lcsh:Diseases of the circulatory (Cardiovascular) system, LVPSP, left ventricular peak systolic pressure, AS, aortic stenosis, COVADIS, coronary vaomotion disorders international study group, LVEDP, left ventricular end-diastolic pressure, NOCAD, non-obstructive coronary artery disease, Acetylcholine testing, Shortness of breath, MPG, mean pressure gradient, MPRI, myocardial perfusion reserve index, LVEF - Left ventricular ejection fraction, Coronary microvascular spasm, LVEDP - Left ventricular end-diastolic pressure, V, velocity, LCA, left coronary artery, Internal medicine, Correspondence, LVEF, left ventricular ejection fraction, Medicine, Coronary microvascular dysfunction, In patient, Coronary vasomotion, AV, aortic valve, PG, pressure gradient, business.industry, AS - Aortic stenosis, Aortic stenosis, CFR, coronary flow reserve, CMD, coronary microvascular dysfunction, AOA, aortic orifice area, medicine.disease, NTG, nitroglycerine, Stenosis, LV, left ventricle, lcsh:RC666-701, Cardiology, ECG, electrocardiogram, VTI, velocity time integral, Cardiology and Cardiovascular Medicine, business, Acetylcholine, RCA, right coronary artery, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5532725da918aace637fa4e7772545c3Test
http://www.sciencedirect.com/science/article/pii/S2352906720303560Test

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Assessing potentiation of the (α4)3(β2)2 nicotinic acetylcholine receptor by the allosteric agonist CMPI

المؤلفون: Farah Deba, Eloisa Peredia, Gustav Akk, Ayman K. Hamouda, Kemburli Munoz

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: Agonist, dFBr, desformylflustrabromine, medicine.drug_class, Allosteric regulation, Xenopus, Gating, positive allosteric modulators, Receptors, Nicotinic, Ligands, Biochemistry, Xenopus laevis, Cytisine, chemistry.chemical_compound, PAMs, positive allosteric modulators, medicine, Animals, Nicotinic Agonists, Binding site, CMPI, Molecular Biology, Binding Sites, biology, ACh, acetylcholine, MWC model, ABS, agonist binding site, Cell Biology, nAChR, nicotinic acetylcholine receptor, biology.organism_classification, CMPI, 3-(2-chlorophenyl)-5-(5-methyl-1-(piperidin-4-yl)-1H-pyrrazol-4-yl)isoxazole, Nicotinic acetylcholine receptor, chemistry, Benzamides, Oocytes, Biophysics, nicotinic acetylcholine receptors, MWC, Monod-Wyman-Changeux, Allosteric Site, Acetylcholine, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d975223d45505aa0086a63ea2ea79e5aTest
https://doi.org/10.1016/j.jbc.2021.101455Test

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Crosstalk between the M

المؤلفون: Karen J, Thompson, Andrew B, Tobin

المصدر: Cellular Signalling

مصطلحات موضوعية: 2-AG, 2-arachidonoyl glycerol, ACEA, arachidonyl-2′-chloroethylamide, CREB, cAMP response element binding, CBD, cannabidiol, CNS, central nervous system, Article, PLC, phospholipase C, AEA, N-arachidonoylethanolamine, Alzheimer Disease, MAGL, monoacylglycerol lipase, APP, amyloid precursor protein, AChE, acetylcholinesterase, Animals, Humans, mAChR, muscarinic acetylcholine receptor, Cannabinoid, Crosstalk, FAAH, fatty acid amide hydrolase, Cholinergic, Endocannabinoid, NAM, negative allosteric modulator, ROCK, RhoA/Rho-associated protein protein kinase, PPARα, peroxisome proliferator-activated receptor α, ACh, acetylcholine, autLTD, autaptic long term depression, Receptor, Muscarinic M1, CHO, Chinese Hamster Ovary, NAGly, N-arachidonyl glycine, PSEN1, presenilin-1, nAChR, nicotinic acetylcholine receptor, GPCR, G protein coupled receptor, EGFP, enhanced green fluorescent protein, Acetylcholine, Aβ, amyloid-beta, PAM, positive allosteric modulator, Δ9-THC1THC, Δ9-tetrahydrocannabinol, PTX, pertussis toxin, Disease Progression, Alzheimer, OP, organophosphorous, AD, Alzheimer's disease, LPI, lysophosphatidyl inositol, DAG, diacylglycerol, MAPK, mitogen-activated protein kinase, Endocannabinoids, ACPA, arachidonylcyclopropylamide

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::1f32aee1a314edcc0e020bb7b35911aaTest
https://pubmed.ncbi.nlm.nih.gov/31978506Test

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The current agonists and positive allosteric modulators of α7 nAChR for CNS indications in clinical trials

المؤلفون: KeWei Wang, Taoyi Yang, Ting Xiao, Qi Sun

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 7, Iss 6, Pp 611-622 (2017)

مصطلحات موضوعية: 0301 basic medicine, Disease, Review Article, Pharmacology, PD, Parkinson's disease, 0302 clinical medicine, α-Btx, α-bungarotoxin, General Pharmacology, Toxicology and Pharmaceutics, 5-HT, serotonin, musculoskeletal, neural, and ocular physiology, Alzheimer's disease, Nicotinic acetylcholine receptor, Schizophrenia, Positive allosteric modulators, AD, Alzheimer's disease, Ion channel, α7 nachr, Acetylcholine, medicine.drug, PPI, prepulse inhibition, Aβ, amyloid-β peptide, MLA, methyllycaconitine, Allosteric regulation, nAChR, CNS, central nervous system, 03 medical and health sciences, PAMs, positive allosteric modulators, mental disorders, SAR, structure–activity relationship, medicine, Homomeric, NOR, novel object recognition, PCP, neonatal phencyclidine, business.industry, ACh, acetylcholine, TMD, transmembrane domains, lcsh:RM1-950, Alpha7, medicine.disease, nAChR, nicotinic acetylcholine receptor, ECD, extracellular domain, Clinical trial, ADHD, attention deficit hyperactivity disorder, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, nervous system, 5-CSRTT, five-choice serial reaction time task, sense organs, business, Neuroscience, DMTS, delayed matching-to-sample, GABA, γ-aminobutyric acid, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c5a852ae12d8369d07f55c284e9906Test
http://europepmc.org/articles/PMC5687317Test

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Probing the binding site of novel selective positive allosteric modulators at the M1 muscarinic acetylcholine receptor

المؤلفون: Celine Valant, Patrick M. Sexton, Elham Khajehali, Peter J. Scammells, Manuela Jörg, Craig W. Lindsley, Arthur Christopoulos, Andrew B. Tobin, P. Jeffrey Conn

المصدر: Biochemical Pharmacology

مصطلحات موضوعية: WT, wild type, 0301 basic medicine, PF-06767832, N-((3R,4S)-3-hydroxytetrahydro-2H-pyran-4-yl)-5-methyl-4-(4-(thiazol-4-yl)benzyl)pyridine-2-carboxamide, Cooperativity, Biochemistry, Muscarinic acetylcholine receptor, Cricetinae, TM, transmembrane domain, BQCA, benzylquinolone carboxylic acid, 1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid, Allosteric modulation, MIPS1780, 3-(2-hydroxycyclohexyl)-6-(2-((4-(1-methyl-1H-pyrazol-4-yl)- benzyl)oxy)phenyl)pyrimidin-4(3H)-one, ANOVA, analysis of variance, Drug discovery, Chemistry, PBZ, phenoxybenzamine, 3. Good health, PAM, positive allosteric modulator, BQZ-12, 3-((1S,2S)-2-hydroxycyclohexyl)-6-((6-(1-methyl-1H-pyrazol-4-yl)pyridin-3-yl)methyl)benzo [h]-quinazolin-4(3H)-one, medicine.symptom, Allosteric Site, Allosteric modulator, DMEM, Dulbecco modified eagle medium, Allosteric regulation, PBS, phosphate-buffered saline, BQCA, CHO Cells, ECL, extracellular loop, Cholinergic Agonists, Muscarinic Agonists, AD, Alzheimer’s disease, CHO, Chinese hamster ovary, Article, NMS, N-methylscopolamine, 03 medical and health sciences, Cricetulus, FBS, fetal bovine serum, Allosteric Regulation, medicine, Animals, Humans, mAChR, muscarinic acetylcholine receptor, Binding site, GPCR, G protein-coupled receptor, ComputingMethodologies_COMPUTERGRAPHICS, NAM, negative allosteric modulator, Pharmacology, IP1, inositol monophosphate, Binding Sites, Dose-Response Relationship, Drug, ACh, acetylcholine, Receptor, Muscarinic M1, VU6004256 (4, 6-difluoro-N-(1S,2S)-2-hydroxycyclohexyl-1-((6-(1-methyl-1H-pyrazol-4-yl)pyridine-3-yl)methyl)-1H-indole-3-carboxamide, Rational design, Acetylcholine, 030104 developmental biology, Mechanism of action, Mutagenesis, HBSS, Hanks’ balanced salt solution, Biophysics, BSA, bovine serum albumin

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825fb21ad2045775ecf4d26ab83b0c2Test
https://eprints.gla.ac.uk/163141/1/163141.pdfTest

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Cardiac contractility modulation increases action potential duration dispersion and decreases ventricular fibrillation threshold via β1-adrenoceptor activation in the crystalloid perfused normal rabbit heart

المؤلفون: Kieran E. Brack, James Winter, John H. Coote, G. André Ng

المصدر: International Journal of Cardiology

مصطلحات موضوعية: Male, medicine.medical_specialty, Potassium Compounds, Refractory period, Cardiac contractility modulation, Non-excitatory stimulation (NES), Action Potentials, Cholinergic Agonists, MAPD90, monophasic action potential duration at 90% repolarization, Autonomic Nervous System, Article, Norepinephrine (medication), Action potential duration dispersion, APD, action potential duration, CCM, cardiac contractility modulation, Internal medicine, medicine, Animals, Ventricular fibrillation, Ganglia, Autonomic, Metoprolol, ACh, acetylcholine, business.industry, Cardiac Pacing, Artificial, Heart, medicine.disease, Adrenergic beta-1 Receptor Antagonists, Myocardial Contraction, Acetylcholine, Perfusion, Autonomic nervous system, LV, left ventricle, Anesthesia, Heart failure, Ventricular arrhythmia, cardiovascular system, Cardiology, Rabbits, Receptors, Adrenergic, beta-1, Electrophysiologic Techniques, Cardiac, Cardiology and Cardiovascular Medicine, business, VFT, ventricular fibrillation threshold, NE, norepinephrine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d0dd06429bf076e1e261c37a223ae2Test
https://doi.org/10.1016/j.ijcard.2013.12.184Test

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Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride accumulation in the mouse liver

المؤلفون: Midori Ando, Kaai Nakamura, Shigenobu Shibata, Shin Ichi Yokota, Fumihiko Hakuno, Shinichiro Takahashi, Hiroyasu Kamei

المصدر: FEBS Open Bio
FEBS Open Bio, Vol 4, Iss C, Pp 905-914 (2014)

مصطلحات موضوعية: FA, fatty acid(s), PPAR-α, peroxisome proliferator activated receptor alpha, medicine.medical_specialty, Physostigmine, Lipolysis, L-FABP, liver fatty acid-binding protein, Biology, Triglyceride, Article, General Biochemistry, Genetics and Molecular Biology, Parasympathetic nerve, chemistry.chemical_compound, AChE, acetylcholinesterase, Fatty liver, Internal medicine, Muscarinic acetylcholine receptor, medicine, lcsh:QH301-705.5, TG, triglyceride(s), VLDL, very low-density lipoprotein(s), CPT-1, carnitine palmitoyltransferase 1, SREBP, sterol regulatory element binding proteins, ACh, acetylcholine, Lipogenesis, PGC-1α, peroxisome proliferator activated receptor gamma coactivator 1-alpha, IRS-2, insulin receptor substrate, Lipid metabolism, medicine.disease, FAS, fatty acid synthase, Metabolic syndrome, Acetylcholinesterase, Fatty acid synthase, Endocrinology, lcsh:Biology (General), chemistry, biology.protein, PEPCK, phosphoenolpyruvate carboxykinase, lipids (amino acids, peptides, and proteins), Acetylcholine, ACC, acetyl coenzyme-A carboxylase, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c02f4d8710db29cd16907803c48bed69Test
https://doi.org/10.1016/j.fob.2014.10.009Test

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