دورية أكاديمية
Significant Improvements in the Practice Patterns of Adult Related Donor Care in US Transplantation Centers
| العنوان: | Significant Improvements in the Practice Patterns of Adult Related Donor Care in US Transplantation Centers |
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| المؤلفون: | Anthias, Chloe, Shaw, Bronwen E., Kiefer, Deidre M., Liesveld, Jane L., Yared, Jean, Kamble, Rammurti T., D'Souza, Anita, Hematti, Peiman, Seftel, Matthew D., Norkin, Maxim, DeFilipp, Zachariah, Kasow, Kimberly A., Abidi, Muneer H., Savani, Bipin N., Shah, Nirali N., Anderlini, Paolo, Diaz, Miguel A., Malone, Adriana K., Halter, Joerg P., Lazarus, Hillard M., Logan, Brent R., Switzer, Galen E., Pulsipher, Michael A., Confer, Dennis L., O'Donnell, Paul V. |
| المصدر: | Biology of Blood and Marrow Transplantation, 22(3) |
| سنة النشر: | 2016 |
| المجموعة: | Carolina Digital Repository (UNC - University of North Carolina) |
| مصطلحات موضوعية: | Humans, Guideline Adherence, Accreditation, Male, United States, Female, Tissue Donors, Adult, Hematopoietic cell donation, Practice Patterns, Physicians', Related donor, Retrospective Studies, Hospitals, Special |
| الوصف: | Recent investigations have found a higher incidence of adverse events associated with hematopoietic cell donation in related donors (RDs) who have morbidities that if present in an unrelated donor (UD) would preclude donation. In the UD setting, regulatory standards ensure independent assessment of donors, one of several crucial measures to safeguard donor health and safety. A survey conducted by the Center for International Blood and Marrow Transplant Research (CIBMTR) Donor Health and Safety Working Committee in 2007 reported a potential conflict of interest in >70% US centers, where physicians had simultaneous responsibility for RDs and their recipients. Consequently, several international organizations have endeavored to improve practice through regulations and consensus recommendations. We hypothesized that the changes in the 2012 FACT-JACIE Standards, resulting from the CIBMTR study, will have significantly impacted practice. Accordingly, a follow-up survey of US transplant centers was conducted to assess practice changes since 2007, and investigate additional areas where RD care was predicted to differ from UD care. 73 centers (53%), performing 79% of US RD transplants responded. Significant improvements were observed since the earlier survey; 62% centers now ensure separation of RD and recipient care (P<0.0001). However, this study identifies several areas where RD management does not meet international donor care standards. Particular concerns include counseling and assessment of donors before HLA typing, with 61% centers first disclosing donor HLA results to an individual other than the donor, the use of unlicensed mobilization agents, and the absence of long-term donor follow-up. Recommendations for improvement are described. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.17615/mhj6-7307Test; https://cdr.lib.unc.edu/downloads/ng451p087?file=thumbnailTest; https://cdr.lib.unc.edu/downloads/ng451p087Test |
| DOI: | 10.17615/mhj6-7307 |
| الإتاحة: | https://doi.org/10.17615/mhj6-7307Test https://cdr.lib.unc.edu/downloads/ng451p087?file=thumbnailTest https://cdr.lib.unc.edu/downloads/ng451p087Test |
| حقوق: | http://rightsstatements.org/vocab/InC/1.0Test/ |
| رقم الانضمام: | edsbas.B53A3AA0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.17615/mhj6-7307 |
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