Background Infectious endocarditis is associated with substantial in-patient mortality of 15-20%. Effective management requires coordination between multiple medical and surgical subspecialties which can often lead to disjointed care. Previous European studies have identified multidisciplinary endocarditis teams as a tool for reducing endocarditis mortality. Methods The University of Michigan Multidisciplinary Endocarditis Team was formed on May 3rd, 2018. The group developed an evidence-based algorithm for management of endocarditis that was used to provide recommendations for hospitalized patients over a 1-year period. Mortality outcomes were then retroactively assessed and compared to a historical control that was identified using an internal research tool. Figure 1 Table 1 Results Between June 14th, 2018 and June 13th, 2019 the team provided guideline-based recommendations on 56 patients with Duke Criteria definite endocarditis and at least 1 American Heart Association indication for surgery. The historical control included 68 patients with definite endocarditis and surgical indications admitted between July 1st, 2014 to June 30th, 2015. In-hospital mortality decreased significantly from 29.4% in 2014-2015 to 7.1% in 2018-2019 (p< 0.0001). There was a non-significant increase in the rate of surgical intervention after implementation of the team (41.2% vs 55.4%; p=0.12). Table 2 Table 3 Table 4 Conclusion Implementation of a multidisciplinary endocarditis team was associated with a significant 1-year decrease in all-cause in-hospital mortality for patients with definite endocarditis and surgical indications. In conjunction with previous studies demonstrating their effectiveness, this data supports that widespread adoption of endocarditis teams in North America has the potential to improve outcomes for this patient population. Table 5 Disclosures All Authors: No reported disclosures
