التفاصيل البيبلوغرافية
| العنوان: |
Nondigestible oligosaccharides increase calcium absorption and suppress bone resorption in ovariectomized rats. |
| المؤلفون: |
Zafar, Tasleem A., Weaver, Connie M., Yongdong Zhao, Connie M., Martin, Berdine R., Wastney, Meryl E., Zhao, Yongdong |
| المصدر: |
Journal of Nutrition; Feb2004, Vol. 134 Issue 2, p399-402, 4p, 1 Diagram, 2 Charts |
| مصطلحات موضوعية: |
OLIGOSACCHARIDES, INULIN, CALCIUM metabolism, BONE metabolism, ABSORPTION (Physiology), RATS, BONE resorption, ANIMALS, CALCIUM, DIGESTION, OVARIECTOMY, ABSORPTION |
| مستخلص: |
Nondigestible oligosaccharides (NDO) including inulin and fructooligosaccharides (FOS) have been reported to stimulate calcium absorption. Here we report the effect of a mixture of inulin and FOS (Raftilose Synergy 1, Orafti) on calcium and bone metabolism in ovariectomized (OVX) rats. OVX rats (6 mo old) were fed a semipurified diet for 3 mo in our animal care laboratory for stabilization after ovariectomy. They were then divided into two groups (n = 13/group) and fed either a control or a NDO-supplemented diet (55 g/kg) for 21 d. Catheters were placed in their jugular veins. After 2 d, a tracer ((45)Ca) was administered by gavage or i.v. and blood was sampled for up to 300 min. Urine and fecal samples were collected for 4 d after (45)Ca administration. Femurs were measured for bone mineral density (BMD), breaking strength, and total calcium. Calcium absorption, femoral calcium content, BMD, and bone balance (V(bal)) were significantly increased (P < 0.05) by NDO, whereas the bone resorption rate relative to the bone formation rate was significantly depressed by NDO. We conclude that feeding NDO at 5.5 g/100 g for 21 d has a positive effect on calcium absorption and retention in ovariectomized rats. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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