التفاصيل البيبلوغرافية
| العنوان: |
Fracture fixation in the operative management of hip fractures (FAITH): an international, multicentre, randomised controlled trial |
| المؤلفون: |
Nauth, Aaron, Creek, Aaron T., Zellar, Abby, Lawendy, Abdel Rahman, Dowrick, Adam, Gupta, Ajay, Dadi, Akhil, van Kampen, Albert, Yee, Albert, de Vries, Alexander C., de Mol van Otterloo, Alexander, Garibaldi, Alisha, Liew, Allen, McIntyre, Allison W., Prasad, Amal Shankar, Romero, Amanda W., Rangan, Amar, Oatt, Amber, Sanghavi, Amir, Foley, Amy L., Karlsten, Anders, Dolenc, Andrea, Bucknill, Andrew, Chia, Andrew, Evans, Andrew, Gong, Andrew, Schmidt, Andrew H., Marcantonio, Andrew J., Jennings, Andrew, Ward, Angela, Khanna, Angshuman, Rai, Anil, Smits, Anke B, Horan, Annamarie D., Brekke, Anne Christine, Flynn, Annette, Duraikannan, Aravin, Stødle, Are, van Vugt, Arie B., Luther, Arlene, Zurcher, Arthur W., Jain, Arvind, Amundsen, Asgeir, Moaveni, Ash, van der Pol, Carmen C., Meijer, Joost, van Wessem, Karlijn, Leenen, Luke P.H., Simmermacher, Rogier K J, Blokhuis, Taco J., Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) Investigators |
| المساهمون: |
MS CGO, Cancer, Medische Staf Spoedeisende Hulp, Zorgeenheid Traumatologie, Infection & Immunity |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Aged, 80 and over, Bone Screws, Equipment Design, Female, Femoral Neck Fractures/surgery, Femur Head Necrosis/etiology, Fracture Fixation, Internal/adverse effects, Fracture Healing, Humans, Kaplan-Meier Estimate, Male, Quality of Life, Reoperation/statistics & numerical data, Single-Blind Method, Treatment Outcome, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Non-U.S. Gov't |
| الوصف: |
Background Reoperation rates are high after surgery for hip fractures. We investigated the effect of a sliding hip screw versus cancellous screws on the risk of reoperation and other key outcomes. Methods For this international, multicentre, allocation concealed randomised controlled trial, we enrolled patients aged 50 years or older with a low-energy hip fracture requiring fracture fixation from 81 clinical centres in eight countries. Patients were assigned by minimisation with a centralised computer system to receive a single large-diameter screw with a side-plate (sliding hip screw) or the present standard of care, multiple small-diameter cancellous screws. Surgeons and patients were not blinded but the data analyst, while doing the analyses, remained blinded to treatment groups. The primary outcome was hip reoperation within 24 months after initial surgery to promote fracture healing, relieve pain, treat infection, or improve function. Analyses followed the intention-to-treat principle. This study was registered with ClinicalTrials.gov, number NCT00761813. Findings Between March 3, 2008, and March 31, 2014, we randomly assigned 1108 patients to receive a sliding hip screw (n=557) or cancellous screws (n=551). Reoperations within 24 months did not differ by type of surgical fixation in those included in the primary analysis: 107 (20%) of 542 patients in the sliding hip screw group versus 117 (22%) of 537 patients in the cancellous screws group (hazard ratio [HR] 0·83, 95% CI 0·63–1·09; p=0·18). Avascular necrosis was more common in the sliding hip screw group than in the cancellous screws group (50 patients [9%] vs 28 patients [5%]; HR 1·91, 1·06–3·44; p=0·0319). However, no significant difference was found between the number of medically related adverse events between groups (p=0·82; appendix); these events included pulmonary embolism (two patients [<1%] vs four [1%] patients; p=0·41) and sepsis (seven [1%] vs six [1%]; p=0·79). Interpretation In terms of reoperation rates the sliding hip screw shows no ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
0140-6736 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/355889Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/355889Test |
| حقوق: |
info:eu-repo/semantics/ClosedAccess |
| رقم الانضمام: |
edsbas.6464408C |
| قاعدة البيانات: |
BASE |
