المؤلفون: Lesourd, Anaïs, Magné, Nicolas, Soares, Anaïs, Lemaitre, Caroline, Taha, Muhamed-Kheir, Gueit, Isabelle, Wolff, Michel, Caron, François

المساهمون: Service des maladies infectieuses et tropicales Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Radiologie CHU Rouen, Département de Microbiologie CHU Rouen, Service de Soins Intensifs CHU Rouen, Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur Paris (IP), Unité de Soins Intensifs et de Maladies Infectieuses, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: ISSN: 1471-2334 ; BMC Infectious Diseases ; https://pasteur.hal.science/pasteur-02068710Test ; BMC Infectious Diseases, 2018, 18, pp.226. ⟨10.1186/s12879-018-3119-4⟩.

مصطلحات موضوعية: Meningococcal meningitis, Ventriculitis, Levofloxacin, Cerebral vasculitis, Diagnosis, Magnetic resonance imaging, MESH: Adult, MESH: Aged, MESH: Humans, MESH: Infectious Disease Medicine, MESH: Magnetic Resonance Imaging, MESH: Male, MESH: Meningitis, Bacterial, MESH: Middle Aged, MESH: Neisseria meningitidis, MESH: Staphylococcal Infections, MESH: Staphylococcus aureus, MESH: Streptococcus pneumoniae, 80 and over, MESH: Anti-Bacterial Agents, MESH: Brain, MESH: Cefotaxime, MESH: Cerebral Ventricles, MESH: Cerebral Ventriculitis, MESH: Communicable Disease Control, MESH: Encephalitis/complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

الوصف: International audience ; Background: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. Case presentation: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man. The comparison with previous reports allows to drawn several conclusions: (i) cases occurred in relatively old adults (median age: 65 years); (ii) Streptococcus pneumoniae, N. meningitiditis and Staphylococcus aureus are the leading responsible pathogens; (iii) atypical clinical presentation seems the rule in which meningism often lacks; (iv) in absence of clinical or biological specific parameters, modern brain imaging such as magnetic resonance imaging with gadolinium enhancement is of utmost importance for the diagnosis, leading to anticipate an increase of the diagnosis in the near future, thanks to easier access to such exploration; (v) death or serious sequelae commonly occurred; (vi) prolonged antibiotic courses (6 weeks to 3 months) have been used, without strong rational. In the given case, the patient presented with a lack of meningeal irritation signs. The diagnosis was made by MRI considering a lasting confused state. A four-week antibiotic regimen was successful, combining two weeks of intravenous cefotaxime followed by two weeks of oral levofloxacin much easier to administrate and allowing early rehabilitation.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29776398; pasteur-02068710; https://pasteur.hal.science/pasteur-02068710Test; https://pasteur.hal.science/pasteur-02068710/documentTest; https://pasteur.hal.science/pasteur-02068710/file/LesourdBMC2018.pdfTest; PUBMED: 29776398; PUBMEDCENTRAL: PMC5960165

الإتاحة: https://doi.org/10.1186/s12879-018-3119-4Test
https://pasteur.hal.science/pasteur-02068710Test
https://pasteur.hal.science/pasteur-02068710/documentTest
https://pasteur.hal.science/pasteur-02068710/file/LesourdBMC2018.pdfTest

المؤلفون: Lesourd, Anaïs, Magné, Nicolas, Soares, Anaïs, Lemaitre, Caroline, Taha, Muhamed-Kheir, Gueit, Isabelle, Wolff, Michel, Caron, François

المساهمون: Service des maladies infectieuses et tropicales Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Radiologie CHU Rouen, Département de Microbiologie CHU Rouen, Service de Soins Intensifs CHU Rouen, Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur Paris (IP), Unité de Soins Intensifs et de Maladies Infectieuses, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: ISSN: 1471-2334 ; BMC Infectious Diseases ; https://pasteur.hal.science/pasteur-02068710Test ; BMC Infectious Diseases, 2018, 18, pp.226. ⟨10.1186/s12879-018-3119-4⟩.

مصطلحات موضوعية: Meningococcal meningitis, Ventriculitis, Levofloxacin, Cerebral vasculitis, Diagnosis, Magnetic resonance imaging, MESH: Adult, MESH: Aged, MESH: Humans, MESH: Infectious Disease Medicine, MESH: Magnetic Resonance Imaging, MESH: Male, MESH: Meningitis, Bacterial, MESH: Middle Aged, MESH: Neisseria meningitidis, MESH: Staphylococcal Infections, MESH: Staphylococcus aureus, MESH: Streptococcus pneumoniae, 80 and over, MESH: Anti-Bacterial Agents, MESH: Brain, MESH: Cefotaxime, MESH: Cerebral Ventricles, MESH: Cerebral Ventriculitis, MESH: Communicable Disease Control, MESH: Encephalitis/complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

الوصف: International audience ; Background: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. Case presentation: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man. The comparison with previous reports allows to drawn several conclusions: (i) cases occurred in relatively old adults (median age: 65 years); (ii) Streptococcus pneumoniae, N. meningitiditis and Staphylococcus aureus are the leading responsible pathogens; (iii) atypical clinical presentation seems the rule in which meningism often lacks; (iv) in absence of clinical or biological specific parameters, modern brain imaging such as magnetic resonance imaging with gadolinium enhancement is of utmost importance for the diagnosis, leading to anticipate an increase of the diagnosis in the near future, thanks to easier access to such exploration; (v) death or serious sequelae commonly occurred; (vi) prolonged antibiotic courses (6 weeks to 3 months) have been used, without strong rational. In the given case, the patient presented with a lack of meningeal irritation signs. The diagnosis was made by MRI considering a lasting confused state. A four-week antibiotic regimen was successful, combining two weeks of intravenous cefotaxime followed by two weeks of oral levofloxacin much easier to administrate and allowing early rehabilitation.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29776398; pasteur-02068710; https://pasteur.hal.science/pasteur-02068710Test; https://pasteur.hal.science/pasteur-02068710/documentTest; https://pasteur.hal.science/pasteur-02068710/file/LesourdBMC2018.pdfTest; PUBMED: 29776398; PUBMEDCENTRAL: PMC5960165

الإتاحة: https://doi.org/10.1186/s12879-018-3119-4Test
https://pasteur.hal.science/pasteur-02068710Test
https://pasteur.hal.science/pasteur-02068710/documentTest
https://pasteur.hal.science/pasteur-02068710/file/LesourdBMC2018.pdfTest

المؤلفون: Lesourd, Anaïs, Magné, Nicolas, Soares, Anaïs, Lemaitre, Caroline, Taha, Muhamed-Kheir, Gueit, Isabelle, Wolff, Michel, Caron, François

المساهمون: Service des maladies infectieuses et tropicales Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Service de Radiologie CHU Rouen, Normandie Université (NU)-Normandie Université (NU), Département de microbiologie CHU Rouen, Service de soins intensifs CHU Rouen, Centre National de Référence des Méningocoques et Haemophilus influenzae - National Reference Center Meningococci and Haemophilus influenzae (CNR), Institut Pasteur Paris, Unité de Soins Intensifs et de Maladies Infectieuses, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: ISSN: 1471-2334.

مصطلحات موضوعية: Meningococcal meningitis, Ventriculitis, Levofloxacin, Cerebral vasculitis, Diagnosis, Magnetic resonance imaging, MESH: Adult, MESH: Aged, MESH: Humans, MESH: Infectious Disease Medicine, MESH: Magnetic Resonance Imaging, MESH: Male, MESH: Meningitis, Bacterial, MESH: Middle Aged, MESH: Neisseria meningitidis, MESH: Staphylococcal Infections, MESH: Staphylococcus aureus, MESH: Streptococcus pneumoniae, 80 and over, MESH: Anti-Bacterial Agents, MESH: Brain, MESH: Cefotaxime, MESH: Cerebral Ventricles, MESH: Cerebral Ventriculitis, MESH: Communicable Disease Control, MESH: Encephalitis/complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

الوصف: International audience ; Background: Defined by an infection of the ventricular system of the brain, ventriculitis is usually known as a health-care associated infection. In contrast, primary pyogenic ventriculitis complicating community-acquired meningitis is uncommon, and mainly described in infants. Only seven cases that have occured in adults have been found in the international literature. Case presentation: We report here a new case due to Neisseria meningitidis occurring in an 85 year-old-man. The comparison with previous reports allows to drawn several conclusions: (i) cases occurred in relatively old adults (median age: 65 years); (ii) Streptococcus pneumoniae, N. meningitiditis and Staphylococcus aureus are the leading responsible pathogens; (iii) atypical clinical presentation seems the rule in which meningism often lacks; (iv) in absence of clinical or biological specific parameters, modern brain imaging such as magnetic resonance imaging with gadolinium enhancement is of utmost importance for the diagnosis, leading to anticipate an increase of the diagnosis in the near future, thanks to easier access to such exploration; (v) death or serious sequelae commonly occurred; (vi) prolonged antibiotic courses (6 weeks to 3 months) have been used, without strong rational. In the given case, the patient presented with a lack of meningeal irritation signs. The diagnosis was made by MRI considering a lasting confused state. A four-week antibiotic regimen was successful, combining two weeks of intravenous cefotaxime followed by two weeks of oral levofloxacin much easier to administrate and allowing early rehabilitation.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29776398; pasteur-02068710; https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710Test; https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710/documentTest; https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710/file/LesourdBMC2018.pdfTest; PUBMED: 29776398; PUBMEDCENTRAL: PMC5960165

الإتاحة: https://doi.org/10.1186/s12879-018-3119-4Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710Test
https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710/documentTest
https://hal-pasteur.archives-ouvertes.fr/pasteur-02068710/file/LesourdBMC2018.pdfTest