التفاصيل البيبلوغرافية
| العنوان: |
Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol |
| المؤلفون: |
Driessen, Daphne A.J.J., de Gouw, Didi J.J.M., Stijns, Rutger C.H., Litjens, Geke, Israël, Bas, Philips, Bart W.J., Hermans, John J., Dijkema, Tim, Klarenbeek, Bastiaan R., van der Post, Rachel S., Nagtegaal, Iris D., van Engen-Van Grunsven, Adriana C.H., Brosens, Lodewijk A.A., Veltien, Andor, Zámecnik, Patrik, Scheenen, Tom W.J. |
| المساهمون: |
Pathologie Pathologen staf, Cancer |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
7 Tesla, Lymph node, Magnetic resonance imaging, Nodal staging, Node-to-node correlation, Pathology, Biochemistry, Genetics and Molecular Biology (miscellaneous), Structural Biology, Biotechnology, Journal Article |
| الوصف: |
Background: In various cancer types, the first step towards extended metastatic disease is the presence of lymph node metastases. Imaging methods with sufficient diagnostic accuracy are required to personalize treatment. Lymph node metastases can be detected with ultrasmall superpara-magnetic iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI), but this method needs validation. Here, a workflow is presented, which is designed to compare MRI-visible lymph nodes on a node-to-node basis with histopathology. Methods: In patients with prostate, rectal, periampullary, esophageal, and head-and-neck cancer, in vivo USPIO-enhanced MRI was performed to detect lymph nodes suspicious of harboring metastases. After lymphadenectomy, but before histopathological assessment, a 7 Tesla preclinical ex vivo MRI of the surgical specimen was performed, and in vivo MR images were radiologically matched to ex vivo MR images. Lymph nodes were annotated on the ex vivo MRI for an MR-guided pathological examination of the specimens. Results: Matching lymph nodes of ex vivo MRI to pathology was feasible in all cancer types. The annotated ex vivo MR images enabled a comparison between USPIO-enhanced in vivo MRI and histopathology, which allowed for analyses on a nodal, or at least on a nodal station, basis. Conclusions: A workflow was developed to validate in vivo USPIO-enhanced MRI with histopathology. Guiding the pathologist towards lymph nodes in the resection specimens during histopathological work-up allowed for the analysis at a nodal basis, or at least nodal station basis, of in vivo suspicious lymph nodes with corresponding histopathology, providing direct information for validation of in vivo USPIO-enhanced, MRI-detected lymph nodes. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2409-9279 |
| العلاقة: |
https://dspace.library.uu.nl/handle/1874/446061Test |
| الإتاحة: |
https://dspace.library.uu.nl/handle/1874/446061Test |
| حقوق: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.C8FF026E |
| قاعدة البيانات: |
BASE |
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