دورية أكاديمية
Development and evaluation of a simple treatment eligibility score (HEPSANET) to decentralise hepatitis B care in Africa: a cross-sectional study.
| العنوان: | Development and evaluation of a simple treatment eligibility score (HEPSANET) to decentralise hepatitis B care in Africa: a cross-sectional study. |
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| المؤلفون: | Minier, Nicolas, Guingané, Alice Nanelin, Okeke, Edith, Sinkala, Edford, Johannessen, Asgeir, Andersson, Monique I, Davwar, Pantong, Desalegn, Hailemichael, Duguru, Mary, Fall, Fatou, Mboup, Souleyman, Maponga, Tongai, Matthews, Philippa C, Ramírez Mena, Adrià, Ndow, Gibril, Orlien, Stian M S, Riches, Nicholas, Seydi, Moussa, Sonderup, Mark, Spearman, C Wendy, Stockdale, Alexander J, Taljaard, Jantjie, Vinikoor, Michael, Wandeler, Gilles, Lemoine, Maud, Shimakawa, Yusuke, Sombié, Roger |
| المصدر: | Minier, Nicolas; Guingané, Alice Nanelin; Okeke, Edith; Sinkala, Edford; Johannessen, Asgeir; Andersson, Monique I; Davwar, Pantong; Desalegn, Hailemichael; Duguru, Mary; Fall, Fatou; Mboup, Souleyman; Maponga, Tongai; Matthews, Philippa C; Ramírez Mena, Adrià; Ndow, Gibril; Orlien, Stian M S; Riches, Nicholas; Seydi, Moussa; Sonderup, Mark; Spearman, C Wendy; . (2024). Development and evaluation of a simple treatment eligibility score (HEPSANET) to decentralise hepatitis B care in Africa: a cross-sectional study. The lancet. Gastroenterology & hepatology, 9(4), pp. 323-332. Elsevier 10.1016/S2468-1253(23)00449-1 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2024 |
| المجموعة: | BORIS (Bern Open Repository and Information System, University of Bern) |
| مصطلحات موضوعية: | 610 Medicine & health |
| الوصف: | BACKGROUND Hepatitis B virus (HBV) elimination requires expanding and decentralising HBV care services. However, peripheral health facilities lack access to diagnostic tools to assess eligibility for antiviral therapy. Through the Hepatitis B in Africa Collaborative Network (HEPSANET), we aimed to develop and evaluate a score using tests generally available at lower-level facilities, to simplify the evaluation of antiviral therapy eligibility in people living with HBV. METHODS We surveyed the availability of clinical and laboratory parameters across different health-care levels in sub-Saharan Africa. We used data from the HEPSANET dataset, the largest cross-sectional dataset of treatment-naive people living with HBV in sub-Saharan Africa, to derive and validate the score. Participants from this dataset were included in the analysis if they were aged 18 years or older and had liver fibrosis stages determined by a liver stiffness measurement or liver histopathology. Participants with co-infections or metabolic disorders were excluded. We allocated participants to the derivation and validation sets by geographical site. In the derivation set, we used stepwise logistic regression to identify the best performing parameters for identifying participants that met the 2017 European Association for the Study of the Liver (EASL) criteria. Regression coefficients were converted into integer points to construct simplified algorithms for different health-care levels. In the validation set, we estimated the area under the receiver operating characteristic, sensitivity, and specificity of the simplified algorithm for identifying antiviral therapy eligibility defined by the 2017 EASL criteria. FINDINGS At 11 sites from eight countries that returned surveys, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and platelet count were generally available at district hospital levels, and hepatitis B e antigen and point-of-care HBV DNA tests were available only at regional and provincial hospital levels or above. Among ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://boris.unibe.ch/192996Test/ |
| الإتاحة: | https://doi.org/10.1016/S2468-1253Test(23)00449-1 https://boris.unibe.ch/192996/1/1-s2.0-S2468125323004491-main.pdfTest https://boris.unibe.ch/192996Test/ |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.7DBF1DB5 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |