Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression
| العنوان: | Protein Kinases C-Mediated Regulations of Drug Transporter Activity, Localization and Expression |
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| المؤلفون: | Mayati, Abdullah, Moreau, Amélie, Le Vée, Marc, Stieger, Bruno, Denizot, Claire, Parmentier, Yannick, Fardel, Olivier |
| المساهمون: | Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Technologie Servier, Division of Clinical Pharmacology and Toxicology, University hospital of Zurich [Zurich], CHU Pontchaillou [Rennes], Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), University of Zurich, Fardel, Olivier |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2017, 18 (4), pp.764. ⟨10.3390/ijms18040764⟩ International Journal of Molecular Sciences, Vol 18, Iss 4, p 764 (2017) International Journal of Molecular Sciences, 2017, 18 (4), pp.764. ⟨10.3390/ijms18040764⟩ |
| بيانات النشر: | HAL CCSD, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 1503 Catalysis, 1607 Spectroscopy, 610 Medicine & health, drug transporters, Review, protein kinases C, lcsh:Chemistry, multidrug resistance, 1312 Molecular Biology, 1706 Computer Science Applications, Humans, Phosphorylation, lcsh:QH301-705.5, Protein Kinase C, Solute Carrier Proteins, [SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, 1604 Inorganic Chemistry, Biological Transport, Isoenzymes, enzymes and coenzymes (carbohydrates), lcsh:Biology (General), lcsh:QD1-999, Gene Expression Regulation, Pharmaceutical Preparations, 10199 Clinic for Clinical Pharmacology and Toxicology, ATP-Binding Cassette Transporters, hepatocytes, 1606 Physical and Theoretical Chemistry, pharmacokinetics, 1605 Organic Chemistry, Signal Transduction |
| الوصف: | International audience; Drug transporters are now recognized as major actors in pharmacokinetics, involved notably in drug-drug interactions and drug adverse effects. Factors that govern their activity, localization and expression are therefore important to consider. In the present review, the implications of protein kinases C (PKCs) in transporter regulations are summarized and discussed. Both solute carrier (SLC) and ATP-binding cassette (ABC) drug transporters can be regulated by PKCs-related signaling pathways. PKCs thus target activity, membrane localization and/or expression level of major influx and efflux drug transporters, in various normal and pathological types of cells and tissues, often in a PKC isoform-specific manner. PKCs are notably implicated in membrane insertion of bile acid transporters in liver and, in this way, are thought to contribute to cholestatic or choleretic effects of endogenous compounds or drugs. The exact clinical relevance of PKCs-related regulation of drug transporters in terms of drug resistance, pharmacokinetics, drug-drug interactions and drug toxicity remains however to be precisely determined. This issue is likely important to consider in the context of the development of new drugs targeting PKCs-mediated signaling pathways, for treating notably cancers, diabetes or psychiatric disorders. |
| وصف الملف: | ijms-18-00764.pdf - application/pdf |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c015a65afc65e4d8c87d429d711fbec8Test https://hal-univ-rennes1.archives-ouvertes.fr/hal-01516024Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....c015a65afc65e4d8c87d429d711fbec8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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