دورية أكاديمية
Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma
| العنوان: | Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma |
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| المؤلفون: | Mackay, Alan, Burford, Anna, Carvalho, Diana, Izquierdo, Elisa, Fazal-Salom, Janat, Taylor, Kathryn R, Bjerke, Lynn, Clarke, Matthew, Vinci, Mara, Nandhabalan, Meera, Temelso, Sara, Popov, Sergey, Molinari, Valeria, Raman, Pichai, Waanders, Angela J, Han, Harry J, Gupta, Saumya, Marshall, Lynley, Zacharoulis, Stergios, Vaidya, Sucheta, Mandeville, Henry C, Bridges, Leslie R, Martin, Andrew J, Al-Sarraj, Safa, Chandler, Christopher, Ng, Ho-Keung, Li, Xingang, Mu, Kun, Trabelsi, Saoussen, Brahim, Dorra H'mida-Ben, Baudis, Michael, Jones, Chris |
| المصدر: | Mackay, Alan; Burford, Anna; Carvalho, Diana; Izquierdo, Elisa; Fazal-Salom, Janat; Taylor, Kathryn R; Bjerke, Lynn; Clarke, Matthew; Vinci, Mara; Nandhabalan, Meera; Temelso, Sara; Popov, Sergey; Molinari, Valeria; Raman, Pichai; Waanders, Angela J; Han, Harry J; Gupta, Saumya; Marshall, Lynley; Zacharoulis, Stergios; Vaidya, Sucheta; Mandeville, Henry C; Bridges, Leslie R; Martin, Andrew J; Al-Sarraj, Safa; Chandler, Christopher; Ng, Ho-Keung; Li, Xingang; Mu, Kun; Trabelsi, Saoussen; Brahim, Dorra H'mida-Ben; Baudis, Michael; Jones, Chris; et al (2017). Integrated molecular meta-analysis of 1,000 pediatric high-grade and diffuse intrinsic pontine glioma. Cancer Cell, 32(4):520-537.e5. |
| بيانات النشر: | Cell Press (Elsevier) |
| سنة النشر: | 2017 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Institute of Molecular Life Sciences, 570 Life sciences, biology |
| الوصف: | We collated data from 157 unpublished cases of pediatric high-grade glioma and diffuse intrinsic pontine glioma and 20 publicly available datasets in an integrated analysis of >1,000 cases. We identified co-segregating mutations in histone-mutant subgroups including loss of FBXW7 in H3.3G34R/V, TOP3A rearrangements in H3.3K27M, and BCOR mutations in H3.1K27M. Histone wild-type subgroups are refined by the presence of key oncogenic events or methylation profiles more closely resembling lower-grade tumors. Genomic aberrations increase with age, highlighting the infant population as biologically and clinically distinct. Uncommon pathway dysregulation is seen in small subsets of tumors, further defining the molecular diversity of the disease, opening up avenues for biological study and providing a basis for functionally defined future treatment stratification. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1535-6108 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/142673/1/2017-03-16_Mackay_pHGG_manuscript.pdfTest; https://www.zora.uzh.ch/id/eprint/142673/7/1-s2.0-S1535610817303628-main.pdfTest; info:pmid/28966033; urn:issn:1535-6108 |
| DOI: | 10.5167/uzh-142673 |
| DOI: | 10.1016/j.ccell.2017.08.017 |
| الإتاحة: | https://doi.org/10.5167/uzh-14267310.1016/j.ccell.2017.08.017Test https://www.zora.uzh.ch/id/eprint/142673Test/ https://www.zora.uzh.ch/id/eprint/142673/1/2017-03-16_Mackay_pHGG_manuscript.pdfTest https://www.zora.uzh.ch/id/eprint/142673/7/1-s2.0-S1535610817303628-main.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.77956190 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15356108 |
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| DOI: | 10.5167/uzh-142673 |