دورية أكاديمية
Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report
| العنوان: | Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report |
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| المؤلفون: | Seppala, TT, Dominguez-Valentin, M, Crosbie, EJ, Engel, C, Aretz, S, Macrae, F, Winship, I, Capella, G, Thomas, H, Hovig, E, Nielsen, M, Sijmons, RH, Bertario, L, Bonanni, B, Tibiletti, MG, Cavestro, GM, Mints, M, Gluck, N, Katz, L, Heinimann, K, Vaccaro, CA, Green, K, Lalloo, F, Hill, J, Schmiegel, W, Vangala, D, Perne, C, Strauss, HG, Tecklenburg, J, Holinski-Feder, E, Steinke-Lange, V, Mecklin, JP, Plazzer, JP, Pineda, M, Navarro, M, Vida, JB, Kariv, R, Rosner, G, Pinero, TA, Pavicic, W, Kalfayan, P, Ten Broeke, SW, Jenkins, MA, Sunde, L, Bernstein, I, Burn, J, Greenblatt, M, Cappel, WHDTN, Della Valle, A, Lopez-Koestner, F, Alvarez, K, Buttner, R, Gorgens, H, Morak, M, Holzapfel, S, Huneburg, R, Doeberitz, MV, Loeffler, M, Redler, S, Weitz, J, Pylvanainen, K, Renkonen-Sinisalo, L, Lepisto, A, Hopper, JL, Win, AK, Lindor, NM, Gallinger, S, Marchand, LL, Newcomb, PA, Figueiredo, JC, Thibodeau, SN, Therkildsen, C, Wadt, KAW, Mourits, MJE, Ketabi, Z, Denton, OG, Rodland, EA, Vasen, H, Neffa, F, Esperon, P, Tjandra, D, Moslein, G, Rokkones, E, Sampson, JR, Evans, DG, Moller, P |
| المساهمون: | Genome-Scale Biology (GSB) Research Program, HUS Abdominal Center, Clinicum, II kirurgian klinikka, Department of Surgery, Doctoral Programme in Clinical Research |
| بيانات النشر: | ELSEVIER SCI IRELAND LTD |
| سنة النشر: | 2021 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | Lynch syndrome, Endometrial cancer, Ovarian cancer, Risk-reducing surgery, Hysterectomy, Oophorectomy, MLH1, MSH2, MSH6, PMS2, COLON-CANCER, SURGERY, COLECTOMY, WOMEN, 3126 Surgery, anesthesiology, intensive care, radiology |
| الوصف: | Purpose: This study aimed to report the uptake of hysterectomy and/or bilateral salpingo-oophorectomy (BSO) to prevent gynaecological cancers (risk-reducing surgery [RRS]) in carriers of pathogenic MMR (path_MMR) variants. Methods: The Prospective Lynch Syndrome Database (PLSD) was used to investigate RRS by a cross-sectional study in 2292 female path_MMR carriers aged 30-69 years. Results: Overall, 144, 79, and 517 carriers underwent risk-reducing hysterectomy, BSO, or both combined, respectively. Two-thirds of procedures before 50 years of age were combined hysterectomy and BSO, and 81% of all procedures included BSO. Risk-reducing hysterectomy was performed before age 50 years in 28%, 25%, 15%, and 9%, and BSO in 26%, 25%, 14% and 13% of path_MLH1, path_MSH2, path_MSH6, and path_PMS2 carriers, respectively. Before 50 years of age, 107 of 188 (57%) BSO and 126 of 204 (62%) hysterectomies were performed in women without any prior cancer, and only 5% (20/392) were performed simultaneously with colorectal cancer (CRC) surgery. Conclusion: Uptake of RRS before 50 years of age was low, and RRS was rarely undertaken in association with surgical treatment of CRC. Uptake of RRS aligned poorly with gene-and age-associated risk estimates for endometrial or ovarian cancer that were published recently from PLSD and did not correspond well with current clinical guidelines. The reasons should be clarified. Decision-making on opting for or against RRS and its timing should be better aligned with predicted risk and mortality for endometrial and ovarian cancer in Lynch syn-drome to improve outcomes. (C) 2021 The Author(s). Published by Elsevier Ltd. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Seppala , TT , Dominguez-Valentin , M , Crosbie , EJ , Engel , C , Aretz , S , Macrae , F , Winship , I , Capella , G , Thomas , H , Hovig , E , Nielsen , M , Sijmons , RH , Bertario , L , Bonanni , B , Tibiletti , MG , Cavestro , GM , Mints , M , Gluck , N , Katz , L , Heinimann , K , Vaccaro , CA , Green , K , Lalloo , F , Hill , J , Schmiegel , W , Vangala , D , Perne , C , Strauss , HG , Tecklenburg , J , Holinski-Feder , E , Steinke-Lange , V , Mecklin , JP , Plazzer , JP , Pineda , M , Navarro , M , Vida , JB , Kariv , R , Rosner , G , Pinero , TA , Pavicic , W , Kalfayan , P , Ten Broeke , SW , Jenkins , MA , Sunde , L , Bernstein , I , Burn , J , Greenblatt , M , Cappel , WHDTN , Della Valle , A , Lopez-Koestner , F , Alvarez , K , Buttner , R , Gorgens , H , Morak , M , Holzapfel , S , Huneburg , R , Doeberitz , MV , Loeffler , M , Redler , S , Weitz , J , Pylvanainen , K , Renkonen-Sinisalo , L , Lepisto , A , Hopper , JL , Win , AK , Lindor , NM , Gallinger , S , Marchand , LL , Newcomb , PA , Figueiredo , JC , Thibodeau , SN , Therkildsen , C , Wadt , KAW , Mourits , MJE , Ketabi , Z , Denton , OG , Rodland , EA , Vasen , H , Neffa , F , Esperon , P , Tjandra , D , Moslein , G , Rokkones , E , Sampson , JR , Evans , DG & Moller , P 2021 , ' Uptake of hysterectomy and bilateral salpingooophorectomy in carriers of pathogenic mismatch repair variants: a Prospective Lynch Syndrome Database report ' , European Journal of Cancer , vol. 148 , pp. 124-133 . https://doi.org/10.1016/j.ejca.2021.02.022Test; RIS: urn:24639478853965089D368C64FDB8B0DD; ORCID: /0000-0002-5866-4059/work/104769008; ORCID: /0000-0002-4940-3498/work/104769618; 4662bc55-8c39-49b3-a1f6-57ee2f806601; http://hdl.handle.net/10138/337489Test; 000645079600016 |
| الإتاحة: | http://hdl.handle.net/10138/337489Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.8007071A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |